© 1998 American Heart Association, Inc.
Review |
Stress (Heat Shock) Proteins
Molecular Chaperones in Cardiovascular Biology and Disease
From the Department of Internal Medicine and Integrative Biology Graduate Program, Molecular Cardiology Research Laboratories, The University of Texas Southwestern Medical Center, Dallas, Tex.
Correspondence to Ivor J. Benjamin, MD, Molecular Cardiology Research Laboratories and Integrative Biology Graduate Program, U.T. Southwestern Medical Center, Dallas, TX 75235-8573. E-mail benjamin{at}ryburn.swmed.edu
Abstract—How a cell responds to stress is a central problem in cardiovascular biology. Diverse physiological stresses (eg, heat, hemodynamics, mutant proteins, and oxidative injury) produce multiple changes in a cell that ultimately affect protein structures and function. Cells from different phyla initiate a cascade of events that engage essential proteins, the molecular chaperones, in decisions to repair or degrade damaged proteins as a defense strategy to ensure survival. Accumulative evidence indicates that molecular chaperones such as the heat shock family of stress proteins (HSPs) actively participate in an array of cellular processes, including cytoprotection. The versatility of the ubiquitous HSP family is further enhanced by stress-inducible regulatory networks, both at the transcriptional and posttranscriptional levels. In the present review, we discuss the regulation and function of HSP chaperones and their clinical significance in conditions such as cardiac hypertrophy, vascular wall injury, cardiac surgery, ischemic preconditioning, aging, and, conceivably, mutations in genes encoding contractile proteins and ion channels.
Key Words: stress protein • gene expression • molecular chaperone • transcription factor • vascular biology • aging • ischemia
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M. B. Harris, M. A. Blackstone, H. Ju, V. J. Venema, and R. C. Venema Heat-induced increases in endothelial NO synthase expression and activity and endothelial NO release Am J Physiol Heart Circ Physiol, June 5, 2003; 285(1): H333 - H340. [Abstract] [Full Text] [PDF]
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M. T. Akbar, A. M. C. Lundberg, K. Liu, S. Vidyadaran, K. E. Wells, H. Dolatshad, S. Wynn, D. J. Wells, D. S. Latchman, and J. de Belleroche The Neuroprotective Effects of Heat Shock Protein 27 Overexpression in Transgenic Animals against Kainate-induced Seizures and Hippocampal Cell Death J. Biol. Chem., May 23, 2003; 278(22): 19956 - 19965. [Abstract] [Full Text] [PDF]
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K.-L. Huang, C.-P. Wu, Y.-L. Chen, B.-H. Kang, and Y.-C. Lin Heat stress attenuates air bubble-induced acute lung injury: a novel mechanism of diving acclimatization J Appl Physiol, April 1, 2003; 94(4): 1485 - 1490. [Abstract] [Full Text] [PDF]
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C. Depre, L. Wang, J. E. Tomlinson, V. Gaussin, M. Abdellatif, J. N. Topper, and S. F. Vatner Characterization of pDJA1, a cardiac-specific chaperone found by genomic profiling of the post-ischemic swine heart Cardiovasc Res, April 1, 2003; 58(1): 126 - 135. [Abstract] [Full Text] [PDF]
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 P. L. Hooper Diabetes, Nitric Oxide, and Heat Shock Proteins Diabetes Care, March 1, 2003; 26(3): 951 - 952. [Full Text] [PDF]
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 M. de Perrot, M. Liu, T. K. Waddell, and S. Keshavjee Ischemia-Reperfusion-induced Lung Injury Am. J. Respir. Crit. Care Med., February 15, 2003; 167(4): 490 - 511. [Abstract] [Full Text] [PDF]
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C. Depre, M. Hase, V. Gaussin, A. Zajac, L. Wang, L. Hittinger, B. Ghaleh, X. Yu, R. K. Kudej, T. Wagner, et al. H11 Kinase Is a Novel Mediator of Myocardial Hypertrophy In Vivo Circ. Res., November 29, 2002; 91(11): 1007 - 1014. [Abstract] [Full Text] [PDF]
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Y. Hayashi, Y. Sawa, N. Fukuyama, H. Nakazawa, and H. Matsuda Preoperative Glutamine Administration Induces Heat-Shock Protein 70 Expression and Attenuates Cardiopulmonary Bypass-Induced Inflammatory Response by Regulating Nitric Oxide Synthase Activity Circulation, November 12, 2002; 106(20): 2601 - 2607. [Abstract] [Full Text] [PDF]
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M. Shimizu, M. Tamamori-Adachi, H. Arai, N. Tabuchi, H. Tanaka, and M. Sunamori Lipopolysaccharide pretreatment attenuates myocardial infarct size: A possible mechanism involving heat shock protein 70-inhibitory {kappa}B{alpha} complex and attenuation of nuclear factor {kappa}B J. Thorac. Cardiovasc. Surg., November 1, 2002; 124(5): 933 - 941. [Abstract] [Full Text] [PDF]
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M. Qing, J. F. Vazquez-Jimenez, K. Schumacher, R. S. Bhardwaj, B. Klosterhalfen, R. Minkenberg, B. J. Messmer, G. von Bernuth, and M.-C. Seghaye Moderate hypothermia during cardiopulmonary bypass increases intramyocardial synthesis of heat shock protein 72 J. Thorac. Cardiovasc. Surg., October 1, 2002; 124(4): 724 - 731. [Abstract] [Full Text] [PDF]
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Q. Xu Role of Heat Shock Proteins in Atherosclerosis Arterioscler Thromb Vasc Biol, October 1, 2002; 22(10): 1547 - 1559. [Abstract] [Full Text] [PDF]
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R. S. Decker, M. L. Decker, S. Nakamura, Y.-S. Zhao, S. Hedjbeli, K. R. Harris, and F. J. Klocke HSC73-tubulin complex formation during low-flow ischemia in the canine myocardium Am J Physiol Heart Circ Physiol, October 1, 2002; 283(4): H1322 - H1333. [Abstract] [Full Text] [PDF]
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K. Hirade, O. Kozawa, K. Tanabe, M. Niwa, H. Matsuno, Y. Oiso, S. Akamatsu, H. Ito, K. Kato, Y. Katagiri, et al. Thrombin stimulates dissociation and induction of HSP27 via p38 MAPK in vascular smooth muscle cells Am J Physiol Heart Circ Physiol, September 1, 2002; 283(3): H941 - H948. [Abstract] [Full Text] [PDF]
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A. E. Kabakov, K. R. Budagova, D. S. Latchman, and H. H. Kampinga Stressful preconditioning and HSP70 overexpression attenuate proteotoxicity of cellular ATP depletion Am J Physiol Cell Physiol, August 1, 2002; 283(2): C521 - C534. [Abstract] [Full Text] [PDF]
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P. Eaton, W. Fuller, and M. J. Shattock S-Thiolation of HSP27 Regulates Its Multimeric Aggregate Size Independently of Phosphorylation J. Biol. Chem., June 7, 2002; 277(24): 21189 - 21196. [Abstract] [Full Text] [PDF]
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I. J. Benjamin and E. Christians Exercise, Estrogen, and Ischemic Cardioprotection by Heat Shock Protein 70 Circ. Res., May 3, 2002; 90(8): 833 - 835. [Full Text] [PDF]
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K. C. Kregel Molecular Biology of Thermoregulation: Invited Review: Heat shock proteins: modifying factors in physiological stress responses and acquired thermotolerance J Appl Physiol, May 1, 2002; 92(5): 2177 - 2186. [Abstract] [Full Text] [PDF]
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I. Kurucz, A. Morva, A. Vaag, K.-F. Eriksson, X. Huang, L. Groop, and L. Koranyi Decreased Expression of Heat Shock Protein 72 In Skeletal Muscle of Patients With Type 2 Diabetes Correlates With Insulin Resistance Diabetes, April 1, 2002; 51(4): 1102 - 1109. [Abstract] [Full Text] [PDF]
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H. Luss, W. Schmitz, and J. Neumann A proteasome inhibitor confers cardioprotection Cardiovasc Res, April 1, 2002; 54(1): 140 - 151. [Abstract] [Full Text] [PDF]
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L. Huang, N. F. Mivechi, and D. Moskophidis Insights into Regulation and Function of the Major Stress-Induced hsp70 Molecular Chaperone In Vivo: Analysis of Mice with Targeted Gene Disruption of the hsp70.1 or hsp70.3 Gene Mol. Cell. Biol., December 15, 2001; 21(24): 8575 - 8591. [Abstract] [Full Text] [PDF]
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J. Ohanian, P. Cunliffe, E. Ceppi, A. Alder, E. Heerkens, and V. Ohanian Activation of p38 Mitogen-Activated Protein Kinases by Endothelin and Noradrenaline in Small Arteries, Regulation by Calcium Influx and Tyrosine Kinases, and Their Role in Contraction Arterioscler Thromb Vasc Biol, December 1, 2001; 21(12): 1921 - 1927. [Abstract] [Full Text] [PDF]
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 D. Hatakeyama, O. Kozawa, M. Niwa, H. Matsuno, K. Kato, N. Tatematsu, T. Shibata, and T. Uematsu Inhibition by adenylyl cyclase-cAMP system of ET-1-induced HSP27 in osteoblasts Am J Physiol Endocrinol Metab, December 1, 2001; 281(6): E1260 - E1266. [Abstract] [Full Text] [PDF]
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T. Ooie, N. Takahashi, T. Saikawa, T. Nawata, M. Arikawa, K. Yamanaka, M. Hara, T. Shimada, and T. Sakata Single Oral Dose of Geranylgeranylacetone Induces Heat-Shock Protein 72 and Renders Protection Against Ischemia/Reperfusion Injury in Rat Heart Circulation, October 9, 2001; 104(15): 1837 - 1843. [Abstract] [Full Text] [PDF]
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 L. H. E. H. Snoeckx, R. N. Cornelussen, F. A. Van Nieuwenhoven, R. S. Reneman, and G. J. Van der Vusse Heat Shock Proteins and Cardiovascular Pathophysiology Physiol Rev, October 1, 2001; 81(4): 1461 - 1497. [Abstract] [Full Text] [PDF]
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 J. George, A. Afek, B. Gilburd, Y. Shoenfeld, and D. Harats Cellular and humoral immune responses to heat shock protein 65 are both involved in promoting fatty-streak formation in LDL-receptor deficient mice J. Am. Coll. Cardiol., September 1, 2001; 38(3): 900 - 905. [Abstract] [Full Text] [PDF]
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O. Eickelberg, J. Geibel, F. Seebach, G. Giebisch, and M. Kashgarian K+-induced HSP-72 expression is mediated via rapid Ca2+ influx in renal epithelial cells Am J Physiol Renal Physiol, August 1, 2001; 281(2): F280 - F287. [Abstract] [Full Text] [PDF]
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 C. Depre, J. E. Tomlinson, R. K. Kudej, V. Gaussin, E. Thompson, S.-J. Kim, D. E. Vatner, J. N. Topper, and S. F. Vatner Gene program for cardiac cell survival induced by transient ischemia in conscious pigs PNAS, July 31, 2001; 98(16): 9336 - 9341. [Abstract] [Full Text] [PDF]
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