Donate Help Contact The AHA Sign In Home
American Heart Association
Circulation Research
Search: search_blue_button Advanced Search
Circulation Research. 1998;83:969-979

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Recchia, F. A.
Right arrow Articles by Hintze, T. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Recchia, F. A.
Right arrow Articles by Hintze, T. H.
(Circulation Research. 1998;83:969-979.)
© 1998 American Heart Association, Inc.


Original Contributions

Reduced Nitric Oxide Production and Altered Myocardial Metabolism During the Decompensation of Pacing-Induced Heart Failure in the Conscious Dog

Fabio A. Recchia, Patrick I. McConnell, Robert D. Bernstein, Traci R. Vogel, Xiaobin Xu, , Thomas H. Hintze

From the Department of Physiology, New York Medical College, Valhalla.

Correspondence to Thomas Hintze, PhD, Department of Physiology, New York Medical College, Valhalla, NY 10595. E-mail Thomas_Hintze{at}nymc.edu

Abstract—The aim of the present study was to determine whether cardiac nitric oxide (NO) production changes during the progression of pacing-induced heart failure and whether this occurs in association with alterations in myocardial metabolism. Dogs (n=8) were instrumented and the heart paced until left ventricular end-diastolic pressure reached 25 mm Hg and clinical signs of severe failure were evident. Every week, hemodynamic measurements were recorded and blood samples were withdrawn from the aorta and the coronary sinus for measurement of NO metabolites, O2 content, free fatty acids (FFAs), and lactate and glucose concentrations. Cardiac production of NO metabolites or consumption of O2 or utilization of substrates was calculated as coronary sinus-arterial difference times coronary flow. In end-stage failure, occurring at 29±1.6 days, left ventricular end-diastolic pressure was 25±1 mm Hg, left ventricular systolic pressure was 92±3 mm Hg, mean arterial pressure was 75±2.5 mm Hg, and dP/dtmax was 1219±73 mm Hg/s (all P<0.05). These changes in hemodynamics were associated with a fall of cardiac NO metabolite production from 0.37±0.16 to -0.28±0.13 nmol/beat (P<0.05). O2 consumption and lactate uptake did not change significantly from control, while FFA uptake decreased from 0.16±0.03 to 0.05±0.01 µEq/beat and glucose uptake increased from -2.3±7.0 to 41±10 µg/beat (P<0.05). The cardiac respiratory quotient also increased significantly by 28%. In 14 normal dogs the same measurements were performed at control and 1 hour after we injected 30 mg/kg of nitro-L-arginine, a competitive inhibitor of NO synthase. O2 consumption increased from 0.05±0.002 mL/beat at control to 0.071±0.003 mL/beat after nitro-L-arginine, while FFA uptake decreased from 0.1±0.01 to 0.06±0.01 µEq/beat, lactate uptake increased from 0.15±0.04 to 0.31±0.03 µmol/beat, glucose uptake increased from 8.2±5.0 to 35.4±9.5 µg/beat, and RQ increased by 23% (all P<0.05). Our results indicate that basal cardiac production of NO falls below normal levels during cardiac decompensation and that there are shifts in substrate utilization. This switch in myocardial substrate utilization also occurs after acute pharmacological blockade of NO production in normal dogs.


Key Words: MVO2 • lactate • free fatty acid • glucose • respiratory quotient




This article has been cited by other articles:


Home page
CirculationHome page
D. Fraccarollo, J. D. Widder, P. Galuppo, T. Thum, D. Tsikas, M. Hoffmann, H. Ruetten, G. Ertl, and J. Bauersachs
Improvement in Left Ventricular Remodeling by the Endothelial Nitric Oxide Synthase Enhancer AVE9488 After Experimental Myocardial Infarction
Circulation, August 19, 2008; 118(8): 818 - 827.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
J. G. Williams, C. Ojaimi, K. Qanud, S. Zhang, X. Xu, F. A. Recchia, and T. H. Hintze
Coronary nitric oxide production controls cardiac substrate metabolism during pregnancy in the dog
Am J Physiol Heart Circ Physiol, June 1, 2008; 294(6): H2516 - H2523.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
D. Neglia, A. De Caterina, P. Marraccini, A. Natali, M. Ciardetti, C. Vecoli, A. Gastaldelli, D. Ciociaro, P. Pellegrini, R. Testa, et al.
Impaired myocardial metabolic reserve and substrate selection flexibility during stress in patients with idiopathic dilated cardiomyopathy
Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3270 - H3278.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
V. Lionetti, L. Guiducci, A. Simioniuc, G. D. Aquaro, C. Simi, D. De Marchi, S. Burchielli, L. Pratali, M. Piacenti, M. Lombardi, et al.
Mismatch between uniform increase in cardiac glucose uptake and regional contractile dysfunction in pacing-induced heart failure
Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H2747 - H2756.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
H. Ashrafian, M. P. Frenneaux, and L. H. Opie
Metabolic Mechanisms in Heart Failure
Circulation, July 24, 2007; 116(4): 434 - 448.
[Abstract] [Full Text] [PDF]


Home page
J. Pharmacol. Exp. Ther.Home page
V. Labinskyy, M. Bellomo, M. P. Chandler, M. E. Young, V. Lionetti, K. Qanud, F. Bigazzi, T. Sampietro, W. C. Stanley, and F. A. Recchia
Chronic Activation of Peroxisome Proliferator-Activated Receptor-{alpha} with Fenofibrate Prevents Alterations in Cardiac Metabolic Phenotype without Changing the Onset of Decompensation in Pacing-Induced Heart Failure
J. Pharmacol. Exp. Ther., April 1, 2007; 321(1): 165 - 171.
[Abstract] [Full Text] [PDF]


Home page
J. Physiol.Home page
E. N. Dedkova, Y. G. Wang, X. Ji, L. A. Blatter, A. M. Samarel, and S. L. Lipsius
Signalling mechanisms in contraction-mediated stimulation of intracellular NO production in cat ventricular myocytes
J. Physiol., April 1, 2007; 580(1): 327 - 345.
[Abstract] [Full Text] [PDF]


Home page
Physiol. GenomicsHome page
C. Ojaimi, K. Qanud, T. H. Hintze, and F. A. Recchia
Altered expression of a limited number of genes contributes to cardiac decompensation during chronic ventricular tachypacing in dogs
Physiol Genomics, March 14, 2007; 29(1): 76 - 83.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
A. P. Saliaris, L. C. Amado, K. M. Minhas, K. H. Schuleri, S. Lehrke, M. St. John, T. Fitton, C. Barreiro, C. Berry, M. Zheng, et al.
Chronic allopurinol administration ameliorates maladaptive alterations in Ca2+ cycling proteins and beta-adrenergic hyporesponsiveness in heart failure
Am J Physiol Heart Circ Physiol, March 1, 2007; 292(3): H1328 - H1335.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
N. Suematsu, C. Ojaimi, S. Kinugawa, Z. Wang, X. Xu, A. Koller MD, F. A. Recchia, and T. H. Hintze
Hyperhomocysteinemia Alters Cardiac Substrate Metabolism by Impairing Nitric Oxide Bioavailability Through Oxidative Stress
Circulation, January 16, 2007; 115(2): 255 - 262.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
J. D. Horowitz and J. A. Kennedy
Time to Address the Cardiac Metabolic "Triple Whammy": Ischemic Heart Failure in Diabetic Patients
J. Am. Coll. Cardiol., December 5, 2006; 48(11): 2232 - 2234.
[Full Text] [PDF]


Home page
SEMIN CARDIOTHORAC VASC ANESTHHome page
G. D. Lopaschuk
Optimizing cardiac Fatty Acid and glucose metabolism as an approach to treating heart failure.
Seminars in Cardiothoracic and Vascular Anesthesia, September 1, 2006; 10(3): 228 - 230.
[Abstract] [PDF]


Home page
Infect. Immun.Home page
A. Mullick, Z. Leon, G. Min-Oo, J. Berghout, R. Lo, E. Daniels, and P. Gros
Cardiac Failure in C5-Deficient A/J Mice after Candida albicans Infection.
Infect. Immun., August 1, 2006; 74(8): 4439 - 4451.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
H. Post and B. Pieske
Arginase: a modulator of myocardial function
Am J Physiol Heart Circ Physiol, May 1, 2006; 290(5): H1747 - H1748.
[Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
Y. Chen, Y. Li, P. Zhang, J. H. Traverse, M. Hou, X. Xu, M. Kimoto, and R. J. Bache
Dimethylarginine dimethylaminohydrolase and endothelial dysfunction in failing hearts
Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H2212 - H2219.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
C. Ojaimi, W. Li, S. Kinugawa, H. Post, A. Csiszar, P. Pacher, G. Kaley, and T. H. Hintze
Transcriptional basis for exercise limitation in male eNOS-knockout mice with age: heart failure and the fetal phenotype
Am J Physiol Heart Circ Physiol, October 1, 2005; 289(4): H1399 - H1407.
[Abstract] [Full Text] [PDF]


Home page
Physiol. Rev.Home page
W. C. Stanley, F. A. Recchia, and G. D. Lopaschuk
Myocardial Substrate Metabolism in the Normal and Failing Heart
Physiol Rev, July 1, 2005; 85(3): 1093 - 1129.
[Abstract] [Full Text] [PDF]


Home page
Cardiovasc ResHome page
V. Lionetti, A. Linke, M. P. Chandler, M. E. Young, M. S. Penn, S. Gupte, C. d'Agostino, T. H. Hintze, W. C. Stanley, and F. A. Recchia
Carnitine palmitoyl transferase-I inhibition prevents ventricular remodeling and delays decompensation in pacing-induced heart failure
Cardiovasc Res, June 1, 2005; 66(3): 454 - 461.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
B. Lei, K. Matsuo, V. Labinskyy, N. Sharma, M. P. Chandler, A. Ahn, T. H. Hintze, W. C. Stanley, and F. A. Recchia
Exogenous nitric oxide reduces glucose transporters translocation and lactate production in ischemic myocardium in vivo
PNAS, May 10, 2005; 102(19): 6966 - 6971.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
P. H. McNulty, N. King, S. Scott, G. Hartman, J. McCann, M. Kozak, C. E. Chambers, L. M. Demers, and L. I. Sinoway
Effects of supplemental oxygen administration on coronary blood flow in patients undergoing cardiac catheterization
Am J Physiol Heart Circ Physiol, March 1, 2005; 288(3): H1057 - H1062.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
Y. Chen, M. Hou, Y. Li, J. H. Traverse, P. Zhang, D. Salvemini, T. Fukai, and R. J. Bache
Increased superoxide production causes coronary endothelial dysfunction and depressed oxygen consumption in the failing heart
Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H133 - H141.
[Abstract] [Full Text] [PDF]


Home page
Eur Heart J SupplHome page
T. Bachetti, L. Comini, E. Pasini, and R. Ferrari
Anti-cytokine therapy in chronic heart failure: new approaches and unmet promises
Eur. Heart J. Suppl., November 1, 2004; 6(suppl_F): F16 - F21.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
J. Li, X. Hu, P. Selvakumar, R. R. Russell III, S. W. Cushman, G. D. Holman, and L. H. Young
Role of the nitric oxide pathway in AMPK-mediated glucose uptake and GLUT4 translocation in heart muscle
Am J Physiol Endocrinol Metab, November 1, 2004; 287(5): E834 - E841.
[Abstract] [Full Text] [PDF]


Home page
HypertensionHome page
L. Nascimben, J. S. Ingwall, B. H. Lorell, I. Pinz, V. Schultz, K. Tornheim, and R. Tian
Mechanisms for Increased Glycolysis in the Hypertrophied Rat Heart
Hypertension, November 1, 2004; 44(5): 662 - 667.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
M. P. Chandler, J. Kerner, H. Huang, E. Vazquez, A. Reszko, W. Z. Martini, C. L. Hoppel, M. Imai, S. Rastogi, H. N. Sabbah, et al.
Moderate severity heart failure does not involve a downregulation of myocardial fatty acid oxidation
Am J Physiol Heart Circ Physiol, October 1, 2004; 287(4): H1538 - H1543.
[Abstract] [Full Text] [PDF]


Home page
Circ. Res.Home page
J. M. Huss and D. P. Kelly
Nuclear Receptor Signaling and Cardiac Energetics
Circ. Res., September 17, 2004; 95(6): 568 - 578.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
W. J. Paulus and J. G. F. Bronzwaer
Nitric oxide's role in the heart: control of beating or breathing?
Am J Physiol Heart Circ Physiol, July 1, 2004; 287(1): H8 - H13.
[Abstract] [Full Text] [PDF]


Home page
Circ. Res.Home page
S. D. Prabhu
Nitric Oxide Protects Against Pathological Ventricular Remodeling: Reconsideration of the Role of NO in the Failing Heart
Circ. Res., May 14, 2004; 94(9): 1155 - 1157.
[Full Text] [PDF]


Home page
Cardiovasc ResHome page
M. van Bilsen, P. J.H Smeets, A. J Gilde, and G. J van der Vusse
Metabolic remodelling of the failing heart: the cardiac burn-out syndrome?
Cardiovasc Res, February 1, 2004; 61(2): 218 - 226.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
D. A. Wink, K. M. Miranda, T. Katori, D. Mancardi, D. D. Thomas, L. Ridnour, M. G. Espey, M. Feelisch, C. A. Colton, J. M. Fukuto, et al.
Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: a novel redox paradigm
Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2264 - H2276.
[Abstract] [Full Text] [PDF]


Home page
Cardiovasc ResHome page
J.-N. Trochu, S. Mital, X.-p. Zhang, X. Xu, M. Ochoa, J. K Liao, F. A Recchia, and T. H Hintze
Preservation of NO production by statins in the treatment of heart failure
Cardiovasc Res, November 1, 2003; 60(2): 250 - 258.
[Abstract] [Full Text] [PDF]


Home page
Cardiovasc ResHome page
J.-P. Tessier, B. Thurner, E. Jungling, A. Luckhoff, and Y. Fischer
Impairment of glucose metabolism in hearts from rats treated with endotoxin
Cardiovasc Res, October 15, 2003; 60(1): 119 - 130.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
A. Linke, G. Zhao, F. A. Recchia, J. Williams, X. Xu, and T. H. Hintze
Shift in metabolic substrate uptake by the heart during development of alloxan-induced diabetes
Am J Physiol Heart Circ Physiol, August 7, 2003; 285(3): H1007 - H1014.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
A. Adler, E. Messina, B. Sherman, Z. Wang, H. Huang, A. Linke, and T. H. Hintze
NAD(P)H oxidase-generated superoxide anion accounts for reduced control of myocardial O2 consumption by NO in old Fischer 344 rats
Am J Physiol Heart Circ Physiol, August 7, 2003; 285(3): H1015 - H1022.
[Abstract] [Full Text] [PDF]


Home page
Circ. Res.Home page
S. A. Khan, M. W. Skaf, R. W. Harrison, K. Lee, K. M. Minhas, A. Kumar, M. Fradley, A. A. Shoukas, D. E. Berkowitz, and J. M. Hare
Nitric Oxide Regulation of Myocardial Contractility and Calcium Cycling: Independent Impact of Neuronal and Endothelial Nitric Oxide Synthases
Circ. Res., June 27, 2003; 92(12): 1322 - 1329.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
S. P. Jones, J. J. M. Greer, R. van Haperen, D. J. Duncker, R. de Crom, and D. J. Lefer
Endothelial nitric oxide synthase overexpression attenuates congestive heart failure in mice
PNAS, April 15, 2003; 100(8): 4891 - 4896.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
M. P. Czubryt, J. McAnally, G. I. Fishman, and E. N. Olson
Regulation of peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha ) and mitochondrial function by MEF2 and HDAC5
PNAS, February 18, 2003; 100(4): 1711 - 1716.
[Abstract] [Full Text] [PDF]


Home page
Physiol. Rev.Home page
D. L. Brutsaert
Cardiac Endothelial-Myocardial Signaling: Its Role in Cardiac Growth, Contractile Performance, and Rhythmicity
Physiol Rev, January 1, 2003; 83(1): 59 - 115.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
R. J. Scheubel, M. Tostlebe, A. Simm, S. Rohrbach, R. Prondzinsky, F. N. Gellerich, R.-E. Silber, and J. Holtz
Dysfunction of mitochondrial respiratory chain complex I in human failing myocardium is not due to disturbed mitochondrial gene expression
J. Am. Coll. Cardiol., December 18, 2002; 40(12): 2174 - 2181.
[Abstract] [Full Text] [PDF]


Home page
Circ. Res.Home page
D. M. Kaye, M. M. Parnell, and B. A. Ahlers
Reduced Myocardial and Systemic L-Arginine Uptake in Heart Failure
Circ. Res., December 13, 2002; 91(12): 1198 - 1203.
[Abstract] [Full Text] [PDF]


Home page
Arterioscler. Thromb. Vasc. Bio.Home page
X.-P. Zhang, H. Tada, Z. Wang, and T. H. Hintze
cAMP Signal Transduction, A Potential Compensatory Pathway for Coronary Endothelial NO Production After Heart Failure
Arterioscler. Thromb. Vasc. Biol., August 1, 2002; 22(8): 1273 - 1278.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
J. C. Osorio, W. C. Stanley, A. Linke, M. Castellari, Q. N. Diep, A. R. Panchal, T. H. Hintze, G. D. Lopaschuk, and F. A. Recchia
Impaired Myocardial Fatty Acid Oxidation and Reduced Protein Expression of Retinoid X Receptor-{alpha} in Pacing-Induced Heart Failure
Circulation, July 30, 2002; 106(5): 606 - 612.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
J. N. Rottman, D. Bracy, C. Malabanan, Z. Yue, J. Clanton, and D. H. Wasserman
Contrasting effects of exercise and NOS inhibition on tissue-specific fatty acid and glucose uptake in mice
Am J Physiol Endocrinol Metab, July 1, 2002; 283(1): E116 - E123.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
J. H. Traverse, Y. Chen, M. Hou, and R. J. Bache
Inhibition of NO production increases myocardial blood flow and oxygen consumption in congestive heart failure
Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H2278 - H2283.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
D. B. Haitsma, D. Merkus, J. Vermeulen, P. D. Verdouw, and D. J. Duncker
Nitric oxide production is maintained in exercising swine with chronic left ventricular dysfunction
Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H2198 - H2209.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
D. B. Sawyer and J. Loscalzo
Myocardial Hibernation: Restorative or Preterminal Sleep?
Circulation, April 2, 2002; 105(13): 1517 - 1519.
[Full Text] [PDF]


Home page
Circ. Res.Home page
W. F. Saavedra, N. Paolocci, M. E. St. John, M. W. Skaf, G. C. Stewart, J.-S. Xie, R. W. Harrison, J. Zeichner, D. Mudrick, E. Marban, et al.
Imbalance Between Xanthine Oxidase and Nitric Oxide Synthase Signaling Pathways Underlies Mechanoenergetic Uncoupling in the Failing Heart
Circ. Res., February 22, 2002; 90(3): 297 - 304.
[Abstract] [Full Text] [PDF]


Home page
Cardiovasc ResHome page
L. A Nikolaidis, T. Hentosz, A. Doverspike, R. Huerbin, C. Stolarski, Y.-T. Shen, and R. P Shannon
Catecholamine stimulation is associated with impaired myocardial O2 utilization in heart failure
Cardiovasc Res, February 1, 2002; 53(2): 392 - 404.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
E. D. Lewandowski, R. K. Kudej, L. T. White, J. M. O'Donnell, and S. F. Vatner
Mitochondrial Preference for Short Chain Fatty Acid Oxidation During Coronary Artery Constriction
Circulation, January 22, 2002; 105(3): 367 - 372.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
F. A. Recchia, J. C. Osorio, M. P. Chandler, X. Xu, A. R. Panchal, G. D. Lopaschuk, T. H. Hintze, and W. C. Stanley
Reduced synthesis of NO causes marked alterations in myocardial substrate metabolism in conscious dogs
Am J Physiol Endocrinol Metab, January 1, 2002; 282(1): E197 - E206.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
L. Dai, P. S. Brookes, V. M. Darley-Usmar, and P. G. Anderson
Bioenergetics in cardiac hypertrophy: mitochondrial respiration as a pathological target of NO{middle dot}
Am J Physiol Heart Circ Physiol, December 1, 2001; 281(6): H2261 - H2269.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
L. A. Nikolaidis, T. Hentosz, A. Doverspike, R. Huerbin, C. Stolarski, Y.-T. Shen, and R. P. Shannon
Mechanisms whereby rapid RV pacing causes LV dysfunction: perfusion-contraction matching and NO
Am J Physiol Heart Circ Physiol, December 1, 2001; 281(6): H2270 - H2281.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
T. Ishibashi, K. Kubota, M. Himeno, T. Matsubara, T. Hori, K. Ozaki, M. Yamozoe, Y. Aizawa, J. Yoshida, and M. Nishio
Respiratory alkalosis does not alter NOx concentrations in human plasma and erythrocytes
Am J Physiol Heart Circ Physiol, December 1, 2001; 281(6): H2757 - H2761.
[Abstract] [Full Text] [PDF]


Home page
HypertensionHome page
G. Wiemer, G. Itter, T. Malinski, and W. Linz
Decreased Nitric Oxide Availability in Normotensive and Hypertensive Rats With Failing Hearts After Myocardial Infarction
Hypertension, December 1, 2001; 38(6): 1367 - 1371.
[Abstract] [Full Text] [PDF]


Home page
Cardiovasc ResHome page
J. H Traverse, Y. Chen, M. Crampton, S. Voss, and R. J Bache
Increased extravascular forces limit endothelium-dependent and -independent coronary vasodilation in congestive heart failure
Cardiovasc Res, December 1, 2001; 52(3): 454 - 461.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
W. J. Paulus, S. Frantz, and R. A. Kelly
Nitric Oxide and Cardiac Contractility in Human Heart Failure: Time for Reappraisal
Circulation, November 6, 2001; 104(19): 2260 - 2262.
[Full Text] [PDF]