© 1998 American Heart Association, Inc.
Original Contributions |
Time-Dependent Changes in Matrix Metalloproteinase Activity and Expression During the Progression of Congestive Heart Failure
Relation to Ventricular and Myocyte Function
From the Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, SC.
Correspondence to Francis G. Spinale, MD, PhD, Division of Cardiothoracic Surgery, Room 418 CSB, 171 Ashley Ave, Medical University of South Carolina, Charleston, SC 29425.
Abstract—The development of
congestive heart failure (CHF) is associated with left
ventricular (LV) dilation and myocardial remodeling.
However, fundamental mechanisms that contribute to this remodeling
process with the progression of CHF remain unclear. The matrix
metalloproteinases (MMPs) have been demonstrated to play a significant
role in tissue remodeling in a number of pathological processes. The
present project tested the hypothesis that the LV dilation and
remodeling during the progression of CHF is associated with early
changes in MMP expression and zymographic activity. LV and myocyte
function, collagen content, and MMP expression and zymographic activity
were serially measured during the progression of CHF caused by
pacing-induced supraventricular tachycardia
(SVT) in pigs. After 7 days of SVT, LV end-diastolic
dimension and myocyte length both increased by 15% from control
values, and LV fractional shortening fell by 20%. At the level of the
myocyte, percent shortening fell by 16% after 7 days of SVT, with no
change in the steady-state velocity of shortening. Longer durations of
SVT caused progressive LV dilation, LV pump failure, and myocyte
contractile dysfunction. Specifically, 21 days of SVT resulted in a
>50% increase in LV dimension, a 56% fall in LV fractional
shortening, and a 33% decline in myocyte velocity of shortening. The
decline in LV and myocyte function with 21 days of SVT was accompanied
by signs and symptoms of CHF. Thus, SVT causes time-dependent changes
in LV geometry and function and the subsequent development of CHF. LV
myocardial collagen content and confluence fell by >25% after 7 days
of SVT and were accompanied by an 80% increase in LV myocardial MMP
zymographic activity against the substrate gelatin. After 14 days of
SVT, total LV myocardial collagen content was reduced by 24%, and LV
myocardial MMP zymographic activity increased by >100% from control
values. Interstitial collagenase (MMP-1),
stromelysin (MMP-3), and 72-kD gelatinase (MMP-2) were increased by
2-fold after 7 days of SVT. LV MMP zymographic activity and
abundance remained elevated with longer durations of SVT. The results
of the present study demonstrated that in this model of CHF, early
changes in LV myocardial MMP zymographic activity and protein levels
occurred with the initiation and progression of LV dilation and
dysfunction. These findings suggest that an early contributory
mechanism for the initiation of LV remodeling that occurred in this
model of developing CHF is enhanced expression and potentially
increased activity of LV myocardial MMPs.
Key Words: heart failure • metalloproteinase • myocardial remodeling
This article has been cited by other articles:
 |
|
 |
|
  R. K. Johnston, S. Balasubramanian, H. Kasiganesan, C. F. Baicu, M. R. Zile, and D. Kuppuswamy {beta}3 Integrin-mediated ubiquitination activates survival signaling during myocardial hypertrophy FASEB J, August 1, 2009; 23(8): 2759 - 2771. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E.-Y. Choi, B. W. Choi, S.-A. Kim, S. J. Rhee, C. Y. Shim, Y. J. Kim, S.-M. Kang, J.-W. Ha, and N. Chung Patterns of late gadolinium enhancement are associated with ventricular stiffness in patients with advanced non-ischaemic dilated cardiomyopathy Eur J Heart Fail, June 1, 2009; 11(6): 573 - 580. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Timmers, J. K. van Keulen, I. E. Hoefer, M. F.L. Meijs, B. van Middelaar, K. den Ouden, C. J.A. van Echteld, G. Pasterkamp, and D. P.V. de Kleijn Targeted Deletion of Nuclear Factor {kappa}B p50 Enhances Cardiac Remodeling and Dysfunction Following Myocardial Infarction Circ. Res., March 13, 2009; 104(5): 699 - 706. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Tsutsui, S. Kinugawa, and S. Matsushima Mitochondrial oxidative stress and dysfunction in myocardial remodelling Cardiovasc Res, February 15, 2009; 81(3): 449 - 456. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Pat, C. Killingsworth, T. Denney, J. Zheng, P. Powell, M. Tillson, A. R. Dillon, and L. J. Dell'Italia Dissociation between cardiomyocyte function and remodeling with {beta}-adrenergic receptor blockade in isolated canine mitral regurgitation Am J Physiol Heart Circ Physiol, December 1, 2008; 295(6): H2321 - H2327. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-P. Hsu, C.-Y. Huang, J.-S. Wang, P.-C. Sun, and C.-C. Shih Extracellular Matrix Remodeling Attenuated After Experimental Postinfarct Left Ventricular Aneurysm Repair Ann. Thorac. Surg., October 1, 2008; 86(4): 1243 - 1249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Zavadzkas, R. A. Plyler, S. Bouges, C. N. Koval, W. T. Rivers, C. U. Beck, E. I. Chang, R. E. Stroud, R. Mukherjee, and F. G. Spinale Cardiac-restricted overexpression of extracellular matrix metalloproteinase inducer causes myocardial remodeling and dysfunction in aging mice Am J Physiol Heart Circ Physiol, October 1, 2008; 295(4): H1394 - H1402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Xu, W. Wan, L. Ji, S. Lao, A. S. Powers, W. Zhao, J. M. Erikson, and J. Q. Zhang Exercise training combined with angiotensin II receptor blockade limits post-infarct ventricular remodelling in rats Cardiovasc Res, June 1, 2008; 78(3): 523 - 532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Koitabashi, M. Arai, K. Niwano, A. Watanabe, M. Endoh, M. Suguta, T. Yokoyama, H. Tada, T. Toyama, H. Adachi, et al. Plasma connective tissue growth factor is a novel potential biomarker of cardiac dysfunction in patients with chronic heart failure Eur J Heart Fail, April 1, 2008; 10(4): 373 - 379. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Fazel, L. Chen, D. Angoulvant, S.-H. Li, R. D. Weisel, A. Keating, and R.-K. Li Activation of c-kit is necessary for mobilization of reparative bone marrow progenitor cells in response to cardiac injury FASEB J, March 1, 2008; 22(3): 930 - 940. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Kelly, S. Khan, G. Cockerill, L.L. Ng, M. Thompson, N.J. Samani, and I.B. Squire Circulating Stromelysin-1 (MMP-3): A novel predictor of LV dysfunction, remodelling and all-cause mortality after acute myocardial infarction Eur J Heart Fail, February 1, 2008; 10(2): 133 - 139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Timmers, J. P.G. Sluijter, J. K. van Keulen, I. E. Hoefer, M. G.J. Nederhoff, M.-J. Goumans, P. A. Doevendans, C. J.A. van Echteld, J. A. Joles, P. H. Quax, et al. Toll-Like Receptor 4 Mediates Maladaptive Left Ventricular Remodeling and Impairs Cardiac Function After Myocardial Infarction Circ. Res., February 1, 2008; 102(2): 257 - 264. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Beeri, C. Yosefy, J. L. Guerrero, F. Nesta, S. Abedat, M. Chaput, F. del Monte, M. D. Handschumacher, R. Stroud, S. Sullivan, et al. Mitral regurgitation augments post-myocardial infarction remodeling failure of hypertrophic compensation. J. Am. Coll. Cardiol., January 29, 2008; 51(4): 476 - 486. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. P. Gallegos and R. M. Bolman III Stem Cell Induced Regeneration of Myocardium Card. Surg. Adult, January 1, 2008; 3(2008): 1657 - 1668. [Full Text]
|
|
|
|
 |
|
 F. G. Spinale Myocardial Matrix Remodeling and the Matrix Metalloproteinases: Influence on Cardiac Form and Function Physiol Rev, October 1, 2007; 87(4): 1285 - 1342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Oceandy, R. Yusoff, F. M. Baudoin, L. Neyses, and S. G. Ray Promoter polymorphism of the matrix metalloproteinase 3 gene is associated with regurgitation and left ventricular remodelling in mitral valve prolapse patients Eur J Heart Fail, October 1, 2007; 9(10): 1010 - 1017. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Jones, R. E. Stroud, B. S. Kaplan, A. M. Leone, J. E. Bavaria, J. H. Gorman III, R. C. Gorman, and J. S. Ikonomidis Differential Protein Kinase C Isoform Abundance in Ascending Aortic Aneurysms From Patients With Bicuspid Versus Tricuspid Aortic Valves Circulation, September 11, 2007; 116(11_suppl): I-144 - I-149. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Beeri, C. Yosefy, J. L. Guerrero, S. Abedat, M. D. Handschumacher, R. E. Stroud, S. Sullivan, M. Chaput, D. Gilon, G. J. Vlahakes, et al. Early Repair of Moderate Ischemic Mitral Regurgitation Reverses Left Ventricular Remodeling: A Functional and Molecular Study Circulation, September 11, 2007; 116(11_suppl): I-288 - I-293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. B. Murray, J. D. Gardner, S. P. Levick, G. L. Brower, L. G. Morgan, and J. S. Janicki Response of cardiac mast cells to atrial natriuretic peptide Am J Physiol Heart Circ Physiol, August 1, 2007; 293(2): H1216 - H1222. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Aupperle, J. Garbade, A. Schubert, M. Barten, S. Dhein, H.-A Schoon, and F.-W Mohr Effects of Autologous Stem Cells on Immunohistochemical Patterns and Gene Expression of Metalloproteinases and Their Tissue Inhibitors in Doxorubicin Cardiomyopathy in a Rabbit Model Vet. Pathol., July 1, 2007; 44(4): 494 - 503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. L. Brower, S. P. Levick, and J. S. Janicki Inhibition of matrix metalloproteinase activity by ACE inhibitors prevents left ventricular remodeling in a rat model of heart failure Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H3057 - H3064. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Ikonomidis, J. A. Jones, J. R. Barbour, R. E. Stroud, L. L. Clark, B. S. Kaplan, A. Zeeshan, J. E. Bavaria, J. H. Gorman III, F. G. Spinale, et al. Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with bicuspid or tricuspid aortic valves J. Thorac. Cardiovasc. Surg., April 1, 2007; 133(4): 1028 - 1036. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. K. Graham and A. W. Trafford Spatial disruption and enhanced degradation of collagen with the transition from compensated ventricular hypertrophy to symptomatic congestive heart failure Am J Physiol Heart Circ Physiol, March 1, 2007; 292(3): H1364 - H1372. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-q. Zhong, W. Zhang, H. Gao, Y. Li, M. Zhong, D. Li, C. Zhang, and Y. Zhang Changes in connexin 43, metalloproteinase and tissue inhibitor of metalloproteinase during tachycardia-induced cardiomyopathy in dogs Eur J Heart Fail, January 1, 2007; 9(1): 23 - 29. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Barbour, R. E. Stroud, A. S. Lowry, L. L. Clark, A. M. Leone, J. A. Jones, F. G. Spinale, and J. S. Ikonomidis Temporal disparity in the induction of matrix metalloproteinases and tissue inhibitors of metalloproteinases after thoracic aortic aneurysm formation J. Thorac. Cardiovasc. Surg., October 1, 2006; 132(4): 788 - 795. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Hudson, P. W. Armstrong, W. Ruzyllo, J. Brum, L. Cusmano, P. Krzeski, R. Lyon, M. Quinones, P. Theroux, D. Sydlowski, et al. Effects of Selective Matrix Metalloproteinase Inhibitor (PG-116800) to Prevent Ventricular Remodeling After Myocardial Infarction: Results of the PREMIER (Prevention of Myocardial Infarction Early Remodeling) Trial J. Am. Coll. Cardiol., July 4, 2006; 48(1): 15 - 20. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Ikonomidis, J. A. Jones, J. R. Barbour, R. E. Stroud, L. L. Clark, B. S. Kaplan, A. Zeeshan, J. E. Bavaria, J. H. Gorman III, F. G. Spinale, et al. Expression of Matrix Metalloproteinases and Endogenous Inhibitors Within Ascending Aortic Aneurysms of Patients With Marfan Syndrome Circulation, July 4, 2006; 114(1_suppl): I-365 - I-370. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Morita, S. Khanal, S. Rastogi, G. Suzuki, M. Imai, A. Todor, V. G. Sharov, S. Goldstein, T. P. O'Neill, and H. N. Sabbah Selective matrix metalloproteinase inhibition attenuates progression of left ventricular dysfunction and remodeling in dogs with chronic heart failure Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2522 - H2527. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Milting, A. Kassner, L. Arusoglu, H. E. Meyer, M. Morshuis, R. Brendel, B. Klauke, A. El Banayosy, and R. Korfer Influence of ACE-inhibition and mechanical unloading on the regulation of extracellular matrix proteins in the myocardium of heart transplantation candidates bridged by ventricular assist devices Eur J Heart Fail, May 1, 2006; 8(3): 278 - 283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Alla, A. Kearney-Schwartz, A. Radauceanu, S. D. Dores, B. Dousset, and F. Zannad Early changes in serum markers of cardiac extra-cellular matrix turnover in patients with uncomplicated hypertension and type II diabetes Eur J Heart Fail, March 1, 2006; 8(2): 147 - 153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G.-Y. Wang, M. R. Bergman, A. P. Nguyen, S. Turcato, P. M. Swigart, M. C. Rodrigo, P. C. Simpson, J. S. Karliner, D. H. Lovett, and A. J. Baker Cardiac transgenic matrix metalloproteinase-2 expression directly induces impaired contractility Cardiovasc Res, February 15, 2006; 69(3): 688 - 696. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Spallarossa, P. Altieri, S. Garibaldi, G. Ghigliotti, C. Barisione, V. Manca, P. Fabbi, A. Ballestrero, C. Brunelli, and A. Barsotti Matrix metalloproteinase-2 and -9 are induced differently by doxorubicin in H9c2 cells: The role of MAP kinases and NAD(P)H oxidase Cardiovasc Res, February 15, 2006; 69(3): 736 - 745. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z.-S. Zhang, H.-J. Cheng, K. Onishi, N. Ohte, T. Wannenburg, and C.-P. Cheng Enhanced Inhibition of L-type Ca2+ Current by {beta}3-Adrenergic Stimulation in Failing Rat Heart J. Pharmacol. Exp. Ther., December 1, 2005; 315(3): 1203 - 1211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Matsusaka, M. Ikeuchi, S. Matsushima, T. Ide, T. Kubota, A. M. Feldman, A. Takeshita, K. Sunagawa, and H. Tsutsui Selective disruption of MMP-2 gene exacerbates myocardial inflammation and dysfunction in mice with cytokine-induced cardiomyopathy Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H1858 - H1864. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Orlandi, A. Ciucci, A. Ferlosio, A. Pellegrino, L. Chiariello, and L. G. Spagnoli Increased Expression and Activity of Matrix Metalloproteinases Characterize Embolic Cardiac Myxomas Am. J. Pathol., June 1, 2005; 166(6): 1619 - 1628. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Lionetti, A. Linke, M. P. Chandler, M. E. Young, M. S. Penn, S. Gupte, C. d'Agostino, T. H. Hintze, W. C. Stanley, and F. A. Recchia Carnitine palmitoyl transferase-I inhibition prevents ventricular remodeling and delays decompensation in pacing-induced heart failure Cardiovasc Res, June 1, 2005; 66(3): 454 - 461. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Vellaichamy, M. L. Khurana, J. Fink, and K. N. Pandey Involvement of the NF-{kappa}B/Matrix Metalloproteinase Pathway in Cardiac Fibrosis of Mice Lacking Guanylyl Cyclase/Natriuretic Peptide Receptor A J. Biol. Chem., May 13, 2005; 280(19): 19230 - 19242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Heymans, F. Lupu, S. Terclavers, B. Vanwetswinkel, J.-M. Herbert, A. Baker, D. Collen, P. Carmeliet, and L. Moons Loss or Inhibition of uPA or MMP-9 Attenuates LV Remodeling and Dysfunction after Acute Pressure Overload in Mice Am. J. Pathol., January 1, 2005; 166(1): 15 - 25. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. B. Murray, J. D. Gardner, G. L. Brower, and J. S. Janicki Endothelin-1 mediates cardiac mast cell degranulation, matrix metalloproteinase activation, and myocardial remodeling in rats Am J Physiol Heart Circ Physiol, November 1, 2004; 287(5): H2295 - H2299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. W.M. Fedak, D. S. Smookler, Z. Kassiri, N. Ohno, K. J. Leco, S. Verma, D. A.G. Mickle, K. L. Watson, C. V. Hojilla, W. Cruz, et al. TIMP-3 Deficiency Leads to Dilated Cardiomyopathy Circulation, October 19, 2004; 110(16): 2401 - 2409. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Xie, M. Singh, and K. Singh Differential Regulation of Matrix Metalloproteinase-2 and -9 Expression and Activity in Adult Rat Cardiac Fibroblasts in Response to Interleukin-1{beta} J. Biol. Chem., September 17, 2004; 279(38): 39513 - 39519. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Jayasankar, Y. J. Woo, L. T. Bish, T. J. Pirolli, M. F. Berry, J. Burdick, R. C. Bhalla, R. V. Sharma, T. J. Gardner, and H. L. Sweeney Inhibition of Matrix Metalloproteinase Activity by TIMP-1 Gene Transfer Effectively Treats Ischemic Cardiomyopathy Circulation, September 14, 2004; 110(11_suppl_1): II-180 - II-186. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Sundstrom, J. C. Evans, E. J. Benjamin, D. Levy, M. G. Larson, D. B. Sawyer, D. A. Siwik, W. S. Colucci, P. Sutherland, P. W.F. Wilson, et al. Relations of Plasma Matrix Metalloproteinase-9 to Clinical Cardiovascular Risk Factors and Echocardiographic Left Ventricular Measures: The Framingham Heart Study Circulation, June 15, 2004; 109(23): 2850 - 2856. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Huang, S. N. Hunyor, L. Jiang, O. Kawaguchi, K. Shirota, Y. Ikeda, T. Yuasa, G. Gallagher, B. Zeng, and X. Zheng Remodeling of the chronic severely failing ischemic sheep heart after coronary microembolization: functional, energetic, structural, and cellular responses Am J Physiol Heart Circ Physiol, June 1, 2004; 286(6): H2141 - H2150. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Sakata, K. Yamamoto, T. Mano, N. Nishikawa, J. Yoshida, M. Hori, T. Miwa, and T. Masuyama Activation of Matrix Metalloproteinases Precedes Left Ventricular Remodeling in Hypertensive Heart Failure Rats: Its Inhibition as a Primary Effect of Angiotensin-Converting Enzyme Inhibitor Circulation, May 4, 2004; 109(17): 2143 - 2149. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Mizon-Gerard, P. de Groote, N. Lamblin, X. Hermant, J. Dallongeville, P. Amouyel, C. Bauters, and N. Helbecque Prognostic impact of matrix metalloproteinase gene polymorphisms in patients with heart failure according to the aetiology of left ventricular systolic dysfunction Eur. Heart J., April 2, 2004; 25(8): 688 - 693. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Delgado III, M. A. Nawar, A. M. Zewail, B. Kar, W. K. Vaughn, K. K. Wu, N. Aleksic, N. Sivasubramanian, K. McKay, D. L. Mann, et al. Cyclooxygenase-2 Inhibitor Treatment Improves Left Ventricular Function and Mortality in a Murine Model of Doxorubicin-Induced Heart Failure Circulation, March 23, 2004; 109(11): 1428 - 1433. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Khan, G. W. Moe, N. Nili, E. Rezaei, M. Eskandarian, J. Butany, and B. H. Strauss The cardiac atria are chambers of active remodeling and dynamic collagen turnover during evolving heart failure J. Am. Coll. Cardiol., January 7, 2004; 43(1): 68 - 76. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yamazaki, J.-D. Lee, H. Shimizu, H. Uzui, and T. Ueda Circulating matrix metalloproteinase-2 is elevated in patients with congestive heart failure Eur J Heart Fail, January 1, 2004; 6(1): 41 - 45. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. Chapman and F. G. Spinale Extracellular protease activation and unraveling of the myocardial interstitium: critical steps toward clinical applications Am J Physiol Heart Circ Physiol, January 1, 2004; 286(1): H1 - H10. [Full Text] [PDF]
|
|
|
|
|
|
J. M. Guccione, A. Salahieh, S. M. Moonly, J. Kortsmit, A. W. Wallace, and M. B. Ratcliffe Myosplint decreases wall stress without depressing function in the failing heart: a finite element model study Ann. Thorac. Surg., October 1, 2003; 76(4): 1171 - 1180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hayashidani, H. Tsutsui, M. Ikeuchi, T. Shiomi, H. Matsusaka, T. Kubota, K. Imanaka-Yoshida, T. Itoh, and A. Takeshita Targeted deletion of MMP-2 attenuates early LV rupture and late remodeling after experimental myocardial infarction Am J Physiol Heart Circ Physiol, August 7, 2003; 285(3): H1229 - H1235. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Boixel, V. Fontaine, C. Rucker-Martin, P. Milliez, L. Louedec, J.-B. Michel, M.-P. Jacob, and S. N. Hatem Fibrosis of the left atria during progression of heart failure is associated with increased matrix metalloproteinases in the rat J. Am. Coll. Cardiol., July 16, 2003; 42(2): 336 - 344. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. D. Hoit Matrix metalloproteinases and atrial structural remodeling J. Am. Coll. Cardiol., July 16, 2003; 42(2): 345 - 347. [Full Text] [PDF]
|
|
|
|
 |
|
 J. Joseph, S. Ranganathan, and J. L. Mehta Low Density Lipoproteins Modulate Collagen Metabolism in Fibroblasts Journal of Cardiovascular Pharmacology and Therapeutics, June 1, 2003; 8(2): 161 - 166. [Abstract] [PDF]
|
|
|
|
|
|
N. Nishikawa, K. Yamamoto, Y. Sakata, T. Mano, J. Yoshida, T. Miwa, H. Takeda, M. Hori, and T. Masuyama Differential activation of matrix metalloproteinases in heart failure with and without ventricular dilatation Cardiovasc Res, March 1, 2003; 57(3): 766 - 774. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. King, M. L. Coker, A. Goldberg, J. H. McElmurray III, H. R. Gunasinghe, R. Mukherjee, M. R. Zile, T. P. O'Neill, and F. G. Spinale Selective Matrix Metalloproteinase Inhibition With Developing Heart Failure: Effects on Left Ventricular Function and Structure Circ. Res., February 7, 2003; 92(2): 177 - 185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Qun Gao, G. Sawicki, W. L Suarez-Pinzon, T. Csont, M. Wozniak, P. Ferdinandy, and R. Schulz Matrix metalloproteinase-2 mediates cytokine-induced myocardial contractile dysfunction Cardiovasc Res, February 1, 2003; 57(2): 426 - 433. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. E. J. M. Creemers, J. N. Davis, A. M. Parkhurst, P. Leenders, K. B. Dowdy, E. Hapke, A. M. Hauet, P. G. Escobar, J. P. M. Cleutjens, J. F. M. Smits, et al. Deficiency of TIMP-1 exacerbates LV remodeling after myocardial infarction in mice Am J Physiol Heart Circ Physiol, January 1, 2003; 284(1): H364 - H371. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Peng, D. Gurantz, V. Tran, R. T. Cowling, and B. H. Greenberg Tumor Necrosis Factor-{alpha}-Induced AT1 Receptor Upregulation Enhances Angiotensin II-Mediated Cardiac Fibroblast Responses That Favor Fibrosis Circ. Res., December 13, 2002; 91(12): 1119 - 1126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Tsuruda, G. Boerrigter, B. K. Huntley, J. A. Noser, A. Cataliotti, L. C. Costello-Boerrigter, H. H. Chen, and J. C. Burnett Jr Brain Natriuretic Peptide Is Produced in Cardiac Fibroblasts and Induces Matrix Metalloproteinases Circ. Res., December 13, 2002; 91(12): 1127 - 1134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hein, W. H. Gaasch, and J. Schaper Giant Molecule Titin and Myocardial Stiffness Circulation, September 10, 2002; 106(11): 1302 - 1304. [Full Text] [PDF]
|
|
|
|
|
|
B. Schwartzkopff, M. Fassbach, B. Pelzer, M. Brehm, and B. E. Strauer Elevated serum markers of collagen degradation in patients with mild to moderate dilated cardiomyopathy Eur J Heart Fail, August 1, 2002; 4(4): 439 - 444. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. L. Brower, A. L. Chancey, S. Thanigaraj, B. B. Matsubara, and J. S. Janicki Cause and effect relationship between myocardial mast cell number and matrix metalloproteinase activity Am J Physiol Heart Circ Physiol, August 1, 2002; 283(2): H518 - H525. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Nakamura, K. Egashira, Y. Machida, S. Hayashidani, M. Takeya, H. Utsumi, H. Tsutsui, and A. Takeshita Probucol Attenuates Left Ventricular Dysfunction and Remodeling in Tachycardia-Induced Heart Failure: Roles of Oxidative Stress and Inflammation Circulation, July 16, 2002; 106(3): 362 - 367. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Falk, P.M. Soccal, J. Grunenfelder, G. Hoyt, T. Walther, and R.C. Robbins Regulation of matrix metalloproteinases and effect of MMP-inhibition in heart transplant related reperfusion injury Eur. J. Cardiothorac. Surg., July 1, 2002; 22(1): 53 - 58. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. A. Tibayan, D. T. M. Lai, T. A. Timek, P. Dagum, D. Liang, G. T. Daughters, N. B. Ingels, and D. C. Miller Alterations in left ventricular torsion in tachycardia-induced dilated cardiomyopathy J. Thorac. Cardiovasc. Surg., July 1, 2002; 124(1): 43 - 49. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Chancey, G. L. Brower, and J. S. Janicki Cardiac mast cell-mediated activation of gelatinase and alteration of ventricular diastolic function Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H2152 - H2158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Romanic, S. M. Harrison, W. Bao, C. L. Burns-Kurtis, S. Pickering, J. Gu, E. Grau, J. Mao, G. M. Sathe, E. H. Ohlstein, et al. Myocardial protection from ischemia/reperfusion injury by targeted deletion of matrix metalloproteinase-9 Cardiovasc Res, June 1, 2002; 54(3): 549 - 558. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. S. Bradham, G. Moe, K. A. Wendt, A. A. Scott, A. Konig, M. Romanova, G. Naik, and F. G. Spinale TNF-alpha and myocardial matrix metalloproteinases in heart failure: relationship to LV remodeling Am J Physiol Heart Circ Physiol, April 1, 2002; 282(4): H1288 - H1295. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. G. Spinale Matrix Metalloproteinases: Regulation and Dysregulation in the Failing Heart Circ. Res., March 22, 2002; 90(5): 520 - 530. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Y. Li, T. Kadokami, P. Wang, C. F. McTiernan, and A. M. Feldman MMP inhibition modulates TNF-alpha transgenic mouse phenotype early in the development of heart failure Am J Physiol Heart Circ Physiol, March 1, 2002; 282(3): H983 - H989. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. S. Bradham, B. Bozkurt, H. Gunasinghe, D. Mann, and F. G. Spinale Tumor necrosis factor-alpha and myocardial remodeling in progression of heart failure: a current perspective Cardiovasc Res, March 1, 2002; 53(4): 822 - 830. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Walther, A. Schubert, V. Falk, C. Binner, A. Kanev, S. Bleiziffer, C. Walther, N. Doll, R. Autschbach, and F. W. Mohr Regression of Left Ventricular Hypertrophy After Surgical Therapy for Aortic Stenosis Is Associated With Changes in Extracellular Matrix Gene Expression Circulation, September 18, 2001; 104 (2009): I-54 - I-58. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Y. Li, Y. Feng, C. F. McTiernan, W. Pei, C. S. Moravec, P. Wang, W. Rosenblum, R. L. Kormos, and A. M. Feldman Downregulation of Matrix Metalloproteinases and Reduction in Collagen Damage in the Failing Human Heart After Support With Left Ventricular Assist Devices Circulation, September 4, 2001; 104(10): 1147 - 1152. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. E.J.M. Creemers, J. P.M. Cleutjens, J. F.M. Smits, and M. J.A.P. Daemen Matrix Metalloproteinase Inhibition After Myocardial Infarction: A New Approach to Prevent Heart Failure? Circ. Res., August 3, 2001; 89(3): 201 - 210. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Coker, J. R. Jolly, C. Joffs, T. Etoh, J. R. Holder, B. R. Bond, and F. G. Spinale Matrix metalloproteinase expression and activity in isolated myocytes after neurohormonal stimulation Am J Physiol Heart Circ Physiol, August 1, 2001; 281(2): H543 - H551. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Dolgilevich, F. M. Siri, S. A. Atlas, and C. Eng Changes in collagenase and collagen gene expression after induction of aortocaval fistula in rats Am J Physiol Heart Circ Physiol, July 1, 2001; 281(1): H207 - H214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Peterson, H. Hallak, L. Johnson, H. Li, P. M. O'Brien, D. R. Sliskovic, T. M. A. Bocan, M. L. Coker, T. Etoh, and F. G. Spinale Matrix Metalloproteinase Inhibition Attenuates Left Ventricular Remodeling and Dysfunction in a Rat Model of Progressive Heart Failure Circulation, May 8, 2001; 103(18): 2303 - 2309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.H. Yacoub A novel strategy to maximize the efficacy of left ventricular assist devices as a bridge to recovery Eur. Heart J., April 1, 2001; 22(7): 534 - 540. [PDF]
|
|
|
|
|
|
G. L. Brower and J. S. Janicki Contribution of ventricular remodeling to pathogenesis of heart failure in rats Am J Physiol Heart Circ Physiol, February 1, 2001; 280(2): H674 - H683. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Woodiwiss, O. J. Tsotetsi, S. Sprott, E. J. Lancaster, T. Mela, E. S. Chung, T. E. Meyer, and G. R. Norton Reduction in Myocardial Collagen Cross-Linking Parallels Left Ventricular Dilatation in Rat Models of Systolic Chamber Dysfunction Circulation, January 2, 2001; 103(1): 155 - 160. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Siwik, P. J. Pagano, and W. S. Colucci Oxidative stress regulates collagen synthesis and matrix metalloproteinase activity in cardiac fibroblasts Am J Physiol Cell Physiol, January 1, 2001; 280(1): C53 - C60. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Y. Li, Y. Q. Feng, T. Kadokami, C. F. McTiernan, R. Draviam, S. C. Watkins, and A. M. Feldman Myocardial extracellular matrix remodeling in transgenic mice overexpressing tumor necrosis factor alpha can be modulated by anti-tumor necrosis factor alpha therapy PNAS, November 7, 2000; 97(23): 12746 - 12751. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. G. Spinale, M. L. Coker, L. J. Heung, B. R. Bond, H. R. Gunasinghe, T. Etoh, A. T. Goldberg, J. L. Zellner, and A. J. Crumbley A Matrix Metalloproteinase Induction/Activation System Exists in the Human Left Ventricular Myocardium and Is Upregulated in Heart Failure Circulation, October 17, 2000; 102(16): 1944 - 1949. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. B. New, A. C. Sampson, M. K. King, J. W. Hendrick, M. J. Clair, J. H. McElmurray III, J. Mandel, R. Mukherjee, Marc de Gasparo, and F. G. Spinale Effects of Combined Angiotensin II and Endothelin Receptor Blockade With Developing Heart Failure : Effects on Left Ventricular Performance Circulation, September 19, 2000; 102(12): 1447 - 1453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kinugawa, H. Tsutsui, S. Hayashidani, T. Ide, N. Suematsu, S. Satoh, H. Utsumi, and A. Takeshita Treatment With Dimethylthiourea Prevents Left Ventricular Remodeling and Failure After Experimental Myocardial Infarction in Mice : Role of Oxidative Stress Circ. Res., September 1, 2000; 87(5): 392 - 398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Lu, Z. Gunja-Smith, J. F. Woessner, P. C. Ursell, T. Nissen, R. E. Galardy, Y. Xu, P. Zhu, and G. G. Schwartz Matrix metalloproteinases and collagen ultrastructure in moderate myocardial ischemia and reperfusion in vivo Am J Physiol Heart Circ Physiol, August 1, 2000; 279(2): H601 - H609. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. H. Lorell and B. A. Carabello Left Ventricular Hypertrophy : Pathogenesis, Detection, and Prognosis Circulation, July 25, 2000; 102(4): 470 - 479. [Full Text] [PDF]
|
|
|
|
|
|
F. G Spinale, M. L Coker, B. R Bond, and J. L Zellner Myocardial matrix degradation and metalloproteinase activation in the failing heart: a potential therapeutic target Cardiovasc Res, May 1, 2000; 46(2): 225 - 238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. M.C. Dixon, J. Hao, N. L. Reid, and J. C. Roth Effect of chronic AT1 receptor blockade on cardiac Smad overexpression in hereditary cardiomyopathic hamsters Cardiovasc Res, May 1, 2000; 46(2): 286 - 297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.T. Peterson, H. Li, L. Dillon, and J. W. Bryant Evolution of matrix metalloprotease and tissue inhibitor expression during heart failure progression in the infarcted rat Cardiovasc Res, May 1, 2000; 46(2): 307 - 315. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.-Y. Cheung, G. Sawicki, M. Wozniak, W. Wang, M. W. Radomski, and R. Schulz Matrix Metalloproteinase-2 Contributes to Ischemia-Reperfusion Injury in the Heart Circulation, April 18, 2000; 101(15): 1833 - 1839. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Senzaki, N. Paolocci, Y. A. Gluzband, M. L. Lindsey, J. S. Janicki, M. T. Crow, and D. A. Kass {beta}-Blockade Prevents Sustained Metalloproteinase Activation and Diastolic Stiffening Induced by Angiotensin II Combined With Evolving Cardiac Dysfunction Circ. Res., April 14, 2000; 86(7): 807 - 815. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Nagatomo, B. A. Carabello, M. L. Coker, P. J. McDermott, S. Nemoto, M. Hamawaki, and F. G. Spinale Differential effects of pressure or volume overload on myocardial MMP levels and inhibitory control Am J Physiol Heart Circ Physiol, January 1, 2000; 278(1): H151 - H161. [Abstract] [Full Text] [PDF]
|
|