© 1998 American Heart Association, Inc.
Point/Counterpoint |
Gene Therapy for Restenosis
Are We Ready?
From the Gladstone Institute of Cardiovascular Disease and Department of Medicine, University of California, San Francisco.
Correspondence to David Dichek, MD, Gladstone Institute of Cardiovascular Disease, PO Box 419100, San Francisco, CA 94141-9100. E-mail david_dichek{at}quickmail.ucsf.edu
Abstract—The application of gene therapy techniques to the clinical problem of coronary restenosis has generated tremendous attention and enthusiasm. Use of gene transfer technology to prevent a common intractable illness would represent a watershed event for human gene therapy. However, the time is not yet right to initiate gene therapy trials for restenosis. The biology of restenosis is incompletely understood, catheter-based gene delivery is poorly adapted to the coronary circulation, and current gene transfer vectors are ill-suited for safe and effective gene delivery to the coronary artery wall. Basic research designed to overcome these obstacles is currently more appropriate than the initiation of clinical trials.
Key Words: gene therapy • restenosis • adenovirus
This article has been cited by other articles:
 |
|
 |
|
  Z. Luo, G. Y. Akita, T. Date, C. Treleaven, K. A. Vincent, D. Woodcock, S. H. Cheng, R. J. Gregory, and C. Jiang Adenovirus-Mediated Expression of {beta}-Adrenergic Receptor Kinase C-Terminus Reduces Intimal Hyperplasia and Luminal Stenosis of Arteriovenous Polytetrafluoroethylene Grafts in Pigs Circulation, April 5, 2005; 111(13): 1679 - 1684. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. W. Johnson, Y. X. Wu, C. Herdeg, A. Baumbach, A. C. Newby, K. R. Karsch, and M. Oberhoff Stent-Based Delivery of Tissue Inhibitor of Metalloproteinase-3 Adenovirus Inhibits Neointimal Formation in Porcine Coronary Arteries Arterioscler Thromb Vasc Biol, April 1, 2005; 25(4): 754 - 759. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Ribourtout and J. Raymond Gene Therapy and Endovascular Treatment of Intracranial Aneurysms Stroke, March 1, 2004; 35(3): 786 - 793. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Izumi, S. Kim, M. Yoshiyama, Y. Izumiya, K. Yoshida, A. Matsuzawa, H. Koyama, Y. Nishizawa, H. Ichijo, J. Yoshikawa, et al. Activation of Apoptosis Signal-Regulating Kinase 1 in Injured Artery and Its Critical Role in Neointimal Hyperplasia Circulation, December 2, 2003; 108(22): 2812 - 2818. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. C. Lowe, S. N. Oesterle, and L. M. Khachigian Coronary in-stent restenosis: Current status and future strategies J. Am. Coll. Cardiol., January 16, 2002; 39(2): 183 - 193. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Belanger, A. Scaria, H. Lu, J. A. Sullivan, S. H. Cheng, R. J. Gregory, and C. Jiang Fas ligand/Fas-mediated apoptosis in human coronary artery smooth muscle cells: therapeutic implications of fratricidal mode of action Cardiovasc Res, September 1, 2001; 51(4): 749 - 761. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Sriram and C. Patterson Cell Cycle in Vasculoproliferative Diseases : Potential Interventions and Routes of Delivery Circulation, May 15, 2001; 103(19): 2414 - 2419. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. M. LaMuraglia, J. Schiereck, J. Heckenkamp, G. Nigri, P. Waterman, D. Leszczynski, and S. Kossodo Photodynamic Therapy Induces Apoptosis in Intimal Hyperplastic Arteries Am. J. Pathol., September 1, 2000; 157(3): 867 - 875. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Lafont, J. L. Dubois-Rande, P. G. Steg, P. Dupouy, D. Carrie, P. Coste, A. Furber, F. Beygui, L. J. Feldman, S. Rahal, et al. The French randomized optimal stenting trial: a prospective evaluation of provisional stenting guided by coronary velocity reserve and quantitative coronary angiography J. Am. Coll. Cardiol., August 1, 2000; 36(2): 404 - 409. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Eto, H. Shimokawa, J. Hiroki, K. Morishige, T. Kandabashi, Y. Matsumoto, M. Amano, M. Hoshijima, K. Kaibuchi, and A. Takeshita Gene transfer of dominant negative Rho kinase suppresses neointimal formation after balloon injury in pigs Am J Physiol Heart Circ Physiol, June 1, 2000; 278(6): H1744 - H1750. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. O Hiltunen, M. P Turunen, M. Laitinen, and S. Yla-Herttuala Insights into the molecular pathogenesis of atherosclerosis and therapeutic strategies using gene transfer Vascular Medicine, February 1, 2000; 5(1): 41 - 48. [Abstract] [PDF]
|
|
|
|
|
|
P. Sinnaeve, O. Varenne, D. Collen, and S. Janssens Gene therapy in the cardiovascular system: an update Cardiovasc Res, December 1, 1999; 44(3): 498 - 506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G. Cable, Vincent J. Pompili, Timothy O’Brien, and Hartzell V. Schaff Recombinant Gene Transfer of Endothelial Nitric Oxide Synthase Augments Coronary Artery Relaxations During Hypoxia Circulation, November 9, 1999; 100 (2009): II-335 - II-339. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. I. M. Campbell, M. A. Kuliszewski, and D. J. Stewart Cell-Based Gene Transfer to the Pulmonary Vasculature . Endothelial Nitric Oxide Synthase Overexpression Inhibits Monocrotaline-Induced Pulmonary Hypertension Am. J. Respir. Cell Mol. Biol., November 1, 1999; 21(5): 567 - 575. [Abstract] [Full Text]
|
|
|
|
|
|
J. Heckenkamp, D. Leszczynski, J. Schiereck, J. Kung, and G. M. LaMuraglia Different Effects of Photodynamic Therapy and {gamma}-Irradiation on Vascular Smooth Muscle Cells and Matrix : Implications for Inhibiting Restenosis Arterioscler Thromb Vasc Biol, September 1, 1999; 19(9): 2154 - 2161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ruef, A. S. Meshel, Z. Hu, C. Horaist, C. A. Ballinger, L. J. Thompson, V. D. Subbarao, J. A. Dumont, and C. Patterson Flavopiridol Inhibits Smooth Muscle Cell Proliferation In Vitro and Neointimal Formation In Vivo After Carotid Injury in the Rat Circulation, August 10, 1999; 100(6): 659 - 665. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Luo, M. Sata, T. Nguyen, J. M. Kaplan, G. Y. Akita, and K. Walsh Adenovirus-Mediated Delivery of Fas Ligand Inhibits Intimal Hyperplasia After Balloon Injury in Immunologically Primed Animals Circulation, April 13, 1999; 99(14): 1776 - 1779. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Numaguchi, K. Naruse, M. Harada, H. Osanai, S. Mokuno, K. Murase, H. Matsui, Y. Toki, T. Ito, K. Okumura, et al. Prostacyclin Synthase Gene Transfer Accelerates Reendothelialization and Inhibits Neointimal Formation in Rat Carotid Arteries After Balloon Injury Arterioscler Thromb Vasc Biol, March 1, 1999; 19(3): 727 - 733. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Heckenkamp and G. M. Lamuraglia Intimal Hyperplasia, Arterial Remodeling, and Restenosis: An Overview Perspectives in Vascular Surgery and Endovascular Therapy, January 1, 1999; 11(2): 71 - 94. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Baek and K. L. March Gene Therapy for Restenosis : Getting Nearer the Heart of the Matter Circ. Res., February 23, 1998; 82(3): 295 - 305. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Libby Gene Therapy of Restenosis : Promise and Perils Circ. Res., February 23, 1998; 82(3): 404 - 406. [Full Text] [PDF]
|
|
|
|
|
|
Y. Izumi, S. Kim, M. Namba, H. Yasumoto, H. Miyazaki, M. Hoshiga, Y. Kaneda, R. Morishita, Y. Zhan, and H. Iwao Gene Transfer of Dominant-Negative Mutants of Extracellular Signal-Regulated Kinase and c-Jun NH2-Terminal Kinase Prevents Neointimal Formation in Balloon-Injured Rat Artery Circ. Res., June 8, 2001; 88(11): 1120 - 1126. [Abstract] [Full Text] [PDF]
|
|