© 1997 American Heart Association, Inc.
Articles |
Dilated Cardiomyopathy in Transgenic Mice With Cardiac-Specific Overexpression of Tumor Necrosis Factor-
From the Cardiovascular Research Laboratories, the Division of Cardiology (T.K., C.F.M., C.S.F, B.H.L., A.M.F.) and the Division of Transplant Pathology (A.J.D.), University of Pittsburgh Medical Center, and the Biomedical Engineering Program and Pittsburgh NMR Center for Biomedical Research (S.E.S., A.P.K.), Carnegie Mellon University, Pittsburgh, Pa.
Correspondence to Arthur M. Feldman, MD, PhD, Division of Cardiology, University of Pittsburgh Medical Center, 200 Lothrop St, S 572 Scaife Hall, Pittsburgh, PA 15213. E-mail feldma{at}card2.cath.upmc.edu
Abstract The failing human heart expresses tumor
necrosis factor- (TNF-). However, its
pathophysiological significance is not clear. We
previously reported that robust overexpression of TNF- in the murine
heart causes lethal myocarditis. In this study, we modified the
transgene to reduce the production of TNF- by preserving the
destabilizing sequence in TNF- cDNA. Expression was driven by the
murine -myosin heavy chain promoter. Use of this modified construct
allowed us to establish a murine transgenic line (TG). TG offspring
were examined at 6, 12, and 24 weeks. All showed a significantly higher
heart weight–to–body weight ratio. Northern blot analysis
confirmed the expression of transgene in the heart, and enzyme-linked
immunosorbent assay demonstrated the presence of TNF- protein. The
TG heart demonstrated a mild, diffuse, lymphohistiocytic
interstitial inflammatory infiltrate. Cardiomyocyte
necrosis and apoptosis were present but not abundant.
Magnetic resonance imaging showed that the TG heart was significantly
dilated with reduced ejection fraction. Although the left
ventricular dP/dtmax was not different at
baseline, its responsiveness to isoproterenol was significantly blunted
in TG. Atrial natriuretic factor was expressed in the TG
ventricle. A group of TG died spontaneously, and subsequent autopsies
revealed exceptional dilatation of the heart, increased lung weight,
and pleural effusion, suggesting that they died of congestive heart
failure. The cumulative mortality rate at 6 months was 23%. In
conclusion, the mouse overexpressing TNF- recapitulated the
phenotype of congestive heart failure. This provides a novel
model to elucidate the role of this cytokine in the development
of congestive heart failure.
Key Words: tumor necrosis factor- • heart failure • transgenic mouse
This article has been cited by other articles:
 |
|
 |
|
  G. Kewalramani, P. Puthanveetil, F. Wang, M. S. Kim, S. Deppe, A. Abrahani, D. S. Luciani, J. D. Johnson, and B. Rodrigues AMP-activated protein kinase confers protection against TNF-{alpha}-induced cardiac cell death Cardiovasc Res, October 1, 2009; 84(1): 42 - 53. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Zhang, C. J. Cox, K. M. Alvarez, and M. W. Cunningham Cutting Edge: Cardiac Myosin Activates Innate Immune Responses through TLRs J. Immunol., July 1, 2009; 183(1): 27 - 31. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. Patten and M. R. Hall-Porter Small Animal Models of Heart Failure: Development of Novel Therapies, Past and Present Circ Heart Fail, March 1, 2009; 2(2): 138 - 144. [Full Text] [PDF]
|
|
|
|
|
|
X. Palomer, D. Alvarez-Guardia, R. Rodriguez-Calvo, T. Coll, J. C. Laguna, M. M. Davidson, T. O. Chan, A. M. Feldman, and M. Vazquez-Carrera TNF-{alpha} reduces PGC-1{alpha} expression through NF-{kappa}B and p38 MAPK leading to increased glucose oxidation in a human cardiac cell model Cardiovasc Res, March 1, 2009; 81(4): 703 - 712. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Frantz, J. Bauersachs, and G. Ertl Post-infarct remodelling: contribution of wound healing and inflammation Cardiovasc Res, February 15, 2009; 81(3): 474 - 481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hori and K. Nishida Oxidative stress and left ventricular remodelling after myocardial infarction Cardiovasc Res, February 15, 2009; 81(3): 457 - 464. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Bogazzi, D. Russo, F. Raggi, F. Ultimieri, C. Urbani, M. Gasperi, L. Bartalena, and E. Martino Transgenic Mice Overexpressing Growth Hormone (GH) Have Reduced or Increased Cardiac Apoptosis through Activation of Multiple GH-Dependent or -Independent Cell Death Pathways Endocrinology, November 1, 2008; 149(11): 5758 - 5769. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. H. Smeets, B. E. J. Teunissen, A. Planavila, H. de Vogel-van den Bosch, P. H. M. Willemsen, G. J. van der Vusse, and M. van Bilsen Inflammatory Pathways Are Activated during Cardiomyocyte Hypertrophy and Attenuated by Peroxisome Proliferator-activated Receptors PPAR{alpha} and PPAR{delta} J. Biol. Chem., October 24, 2008; 283(43): 29109 - 29118. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Dunlay, S. A. Weston, M. M. Redfield, J. M. Killian, and V. L. Roger Tumor Necrosis Factor-{alpha} and Mortality in Heart Failure: A Community Study Circulation, August 5, 2008; 118(6): 625 - 631. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. G. Bucciarelli, R. Ananthakrishnan, Y. C. Hwang, M. Kaneko, F. Song, D. R. Sell, C. Strauch, V. M. Monnier, S. F. Yan, A. M. Schmidt, et al. RAGE and Modulation of Ischemic Injury in the Diabetic Myocardium Diabetes, July 1, 2008; 57(7): 1941 - 1951. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Shijie, J. Moriya, J. Yamakawa, R. Chen, T. Takahashi, H. Sumino, T. Nakahashi, K. Iwai, S. Morimoto, N. Yamaguchi, et al. Mao-to Prolongs the Survival of and Reduces TNF-{alpha} Expression in Mice with Viral Myocarditis Evid. Based Complement. Altern. Med., February 24, 2008; (2008) nen010v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Witteles and M. B. Fowler Insulin-Resistant Cardiomyopathy: Clinical Evidence, Mechanisms, and Treatment Options J. Am. Coll. Cardiol., January 15, 2008; 51(2): 93 - 102. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Hankiewicz, P. H. Goldspink, P. M. Buttrick, and E. D. Lewandowski Principal strain changes precede ventricular wall thinning during transition to heart failure in a mouse model of dilated cardiomyopathy Am J Physiol Heart Circ Physiol, January 1, 2008; 294(1): H330 - H336. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Konhilas and L. A. Leinwand The Effects of Biological Sex and Diet on the Development of Heart Failure Circulation, December 4, 2007; 116(23): 2747 - 2759. [Full Text] [PDF]
|
|
|
|
 |
|
 S. Bien, A. Riad, C. A. Ritter, M. Gratz, F. Olshausen, D. Westermann, M. Grube, T. Krieg, S. Ciecholewski, S. B. Felix, et al. The Endothelin Receptor Blocker Bosentan Inhibits Doxorubicin-Induced Cardiomyopathy Cancer Res., November 1, 2007; 67(21): 10428 - 10435. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-P. Hsu, C.-Y. Huang, J.-S. Wang, H.-I. Chiang, and C.-C. Shih Down-Regulation of Apoptosis After Left Ventricular Aneurysm Repair Ann. Thorac. Surg., October 1, 2007; 84(4): 1279 - 1287. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Reifenberg, H.-A. Lehr, M. Torzewski, G. Steige, E. Wiese, I. Kupper, C. Becker, S. Ott, P. Nusser, K.-I. Yamamura, et al. Interferon-{gamma} Induces Chronic Active Myocarditis and Cardiomyopathy in Transgenic Mice Am. J. Pathol., August 1, 2007; 171(2): 463 - 472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fernandez-Velasco, G. Ruiz-Hurtado, O. Hurtado, M. A. Moro, and C. Delgado TNF-{alpha} downregulates transient outward potassium current in rat ventricular myocytes through iNOS overexpression and oxidant species generation Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H238 - H245. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Funakoshi, L. C. Zacharia, Z. Tang, J. Zhang, L. L. Lee, J. C. Good, D. E. Herrmann, Y. Higuchi, W. J. Koch, E. K. Jackson, et al. A1 Adenosine Receptor Upregulation Accompanies Decreasing Myocardial Adenosine Levels in Mice With Left Ventricular Dysfunction Circulation, May 1, 2007; 115(17): 2307 - 2315. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sun, M. Chen, F. Dawood, U. Zurawska, J. Y. Li, T. Parker, Z. Kassiri, L. A. Kirshenbaum, M. Arnold, R. Khokha, et al. Tumor Necrosis Factor-{alpha} Mediates Cardiac Remodeling and Ventricular Dysfunction After Pressure Overload State Circulation, March 20, 2007; 115(11): 1398 - 1407. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sekiguchi, Q. Tian, M. Ishiyama, J. Burchfield, F. Gao, D. L. Mann, and P. M. Barger Inhibition of PPAR-{alpha} activity in mice with cardiac-restricted expression of tumor necrosis factor: potential role of TGF-beta/Smad3 Am J Physiol Heart Circ Physiol, March 1, 2007; 292(3): H1443 - H1451. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Khoynezhad Promising aspects and caveats of studies on anti-apoptotic therapies in patients with heart failure Eur J Heart Fail, February 1, 2007; 9(2): 120 - 123. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Dehoux, C. Gobier, P. Lause, L. Bertrand, J.-M. Ketelslegers, and J.-P. Thissen IGF-I does not prevent myotube atrophy caused by proinflammatory cytokines despite activation of Akt/Foxo and GSK-3beta pathways and inhibition of atrogin-1 mRNA Am J Physiol Endocrinol Metab, January 1, 2007; 292(1): E145 - E150. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Hang, Z. Huang, S. Jiang, J. Gong, C. Wang, D. Xie, and H. Ren Apoptosis in pressure overload-induced cardiac hypertrophy is mediated, in part, by adenine nucleotide translocator-1. Ann. Clin. Lab. Sci., December 1, 2006; 36(1): 88 - 95. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Huber, A. M. Feldman, and D. Sartini Coxsackievirus B3 Induces T Regulatory Cells, Which Inhibit Cardiomyopathy in Tumor Necrosis Factor-{alpha} Transgenic Mice Circ. Res., November 10, 2006; 99(10): 1109 - 1116. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. S. Hoare, E. J. Birks, C. Bowles, N. Marczin, and M. H. Yacoub In vitro endothelial cell activation and inflammatory responses in end-stage heart failure J Appl Physiol, November 1, 2006; 101(5): 1466 - 1473. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Frantz, K. Hu, B. Bayer, S. Gerondakis, J. Strotmann, A. Adamek, G. Ertl, and J. Bauersachs Absence of NF-{kappa}B subunit p50 improves heart failure after myocardial infarction FASEB J, September 1, 2006; 20(11): 1918 - 1920. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nishikawa, M. Yoshida, M. Kusuhara, N. Ishigami, K. Isoda, K. Miyazaki, and F. Ohsuzu Left ventricular hypertrophy in mice with a cardiac-specific overexpression of interleukin-1 Am J Physiol Heart Circ Physiol, July 1, 2006; 291(1): H176 - H183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Hayward, N. Bautista-Lopez, K. Suzuki, A. Atrazhev, P. Dickie, and J. F. Elliott CD4 T Cells Play Major Effector Role and CD8 T Cells Initiating Role in Spontaneous Autoimmune Myocarditis of HLA-DQ8 Transgenic IAb Knockout Nonobese Diabetic Mice. J. Immunol., June 15, 2006; 176(12): 7715 - 7725. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Jankowska, P. Ponikowski, M. F. Piepoli, W. Banasiak, S. D. Anker, and P. A. Poole-Wilson Autonomic imbalance and immune activation in chronic heart failure - Pathophysiological links Cardiovasc Res, June 1, 2006; 70(3): 434 - 445. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. S. Petkova-Kirova, E. Gursoy, H. Mehdi, C. F. McTiernan, B. London, and G. Salama Electrical remodeling of cardiac myocytes from mice with heart failure due to the overexpression of tumor necrosis factor-{alpha} Am J Physiol Heart Circ Physiol, May 1, 2006; 290(5): H2098 - H2107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Higuchi, T. O. Chan, M. A. Brown, J. Zhang, B. R. DeGeorge Jr., H. Funakoshi, G. Gibson, C. F. McTiernan, T. Kubota, W. K. Jones, et al. Cardioprotection afforded by NF-{kappa}B ablation is associated with activation of Akt in mice overexpressing TNF-{alpha} Am J Physiol Heart Circ Physiol, February 1, 2006; 290(2): H590 - H598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Matsusaka, M. Ikeuchi, S. Matsushima, T. Ide, T. Kubota, A. M. Feldman, A. Takeshita, K. Sunagawa, and H. Tsutsui Selective disruption of MMP-2 gene exacerbates myocardial inflammation and dysfunction in mice with cytokine-induced cardiomyopathy Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H1858 - H1864. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Chao, Y. Shen, L. Li, H. Zhao, S. E. Meiler, S. A. Cook, and A. Rosenzweig Fas-associated death-domain protein inhibits TNF-{alpha} mediated NF-{kappa}B activation in cardiomyocytes Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H2073 - H2080. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Hall, I. S. Singh, L. Hester, J. D. Hasday, and T. B. Rogers Inhibitor-{kappa}B kinase-{beta} regulates LPS-induced TNF-{alpha} production in cardiac myocytes through modulation of NF-{kappa}B p65 subunit phosphorylation Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H2103 - H2111. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. C. Mehra, V. S. Ramgolam, and J. R. Bender Cytokines and cardiovascular disease J. Leukoc. Biol., October 1, 2005; 78(4): 805 - 818. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Saba, A. M. Janczewski, L. C. Baker, V. Shusterman, E. C. Gursoy, A. M. Feldman, G. Salama, C. F. McTiernan, and B. London Atrial contractile dysfunction, fibrosis, and arrhythmias in a mouse model of cardiomyopathy secondary to cardiac-specific overexpression of tumor necrosis factor-{alpha} Am J Physiol Heart Circ Physiol, October 1, 2005; 289(4): H1456 - H1467. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kawano, T. Kubota, Y. Monden, N. Kawamura, H. Tsutsui, A. Takeshita, and K. Sunagawa Blockade of NF-{kappa}B ameliorates myocardial hypertrophy in response to chronic infusion of angiotensin II Cardiovasc Res, September 1, 2005; 67(4): 689 - 698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Satoh, M. Nakamura, T. Akatsu, Y. Shimoda, I. Segawa, and K. Hiramori Myocardial osteopontin expression is associated with collagen fibrillogenesis in human dilated cardiomyopathy Eur J Heart Fail, August 1, 2005; 7(5): 755 - 762. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Brown, M. McGuinness, T. Wright, X. Ren, Y. Wang, G. P. Boivin, H. Hahn, A. M. Feldman, and W. K. Jones Cardiac-specific blockade of NF-{kappa}B in cardiac pathophysiology: differences between acute and chronic stimuli in vivo Am J Physiol Heart Circ Physiol, July 1, 2005; 289(1): H466 - H476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Kawamura, T. Kubota, S. Kawano, Y. Monden, A. M. Feldman, H. Tsutsui, A. Takeshita, and K. Sunagawa Blockade of NF-{kappa}B improves cardiac function and survival without affecting inflammation in TNF-{alpha}-induced cardiomyopathy Cardiovasc Res, June 1, 2005; 66(3): 520 - 529. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Li, D. Georgakopoulos, G. Lu, L. Hester, D. A. Kass, J. Hasday, and Y. Wang p38 MAP Kinase Mediates Inflammatory Cytokine Induction in Cardiomyocytes and Extracellular Matrix Remodeling in Heart Circulation, May 17, 2005; 111(19): 2494 - 2502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ueland, A. Yndestad, E. Oie, G. Florholmen, B. Halvorsen, S. S. Froland, S. Simonsen, G. Christensen, L. Gullestad, and P. Aukrust Dysregulated Osteoprotegerin/RANK Ligand/RANK Axis in Clinical and Experimental Heart Failure Circulation, May 17, 2005; 111(19): 2461 - 2468. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Grun, B. Markova, F.-D. Bohmer, A. Berndt, H. Kosmehl, and C. Leipner Elevated expression of PDGF-C in coxsackievirus B3-induced chronic myocarditis Eur. Heart J., April 1, 2005; 26(7): 728 - 739. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Meng, L. Ao, Y. Song, C. D. Raeburn, D. A. Fullerton, and A. H. Harken Signaling for myocardial depression in hemorrhagic shock: roles of Toll-like receptor 4 and p55 TNF-{alpha} receptor Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2005; 288(3): R600 - R606. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Prabhu Cytokine-Induced Modulation of Cardiac Function Circ. Res., December 10, 2004; 95(12): 1140 - 1153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ikeuchi, H. Tsutsui, T. Shiomi, H. Matsusaka, S. Matsushima, J. Wen, T. Kubota, and A. Takeshita Inhibition of TGF-{beta} signaling exacerbates early cardiac dysfunction but prevents late remodeling after infarction Cardiovasc Res, December 1, 2004; 64(3): 526 - 535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sun, F. Dawood, W.-H. Wen, M. Chen, I. Dixon, L. A. Kirshenbaum, and P. P. Liu Excessive Tumor Necrosis Factor Activation After Infarction Contributes to Susceptibility of Myocardial Rupture and Left Ventricular Dysfunction Circulation, November 16, 2004; 110(20): 3221 - 3228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. SHARMA, J. V. ADROGUE, L. GOLFMAN, I. URAY, J. LEMM, K. YOUKER, G. P. NOON, O. H FRAZIER, and H. TAEGTMEYER Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart FASEB J, November 1, 2004; 18(14): 1692 - 1700. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. W. Moe, J. Marin-Garcia, A. Konig, M. Goldenthal, X. Lu, and Q. Feng In vivo TNF-{alpha} inhibition ameliorates cardiac mitochondrial dysfunction, oxidative stress, and apoptosis in experimental heart failure Am J Physiol Heart Circ Physiol, October 1, 2004; 287(4): H1813 - H1820. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. von Harsdorf "Fas-ten" Your Seat Belt: Anti-apoptotic Treatment in Heart Failure Takes Off Circ. Res., September 17, 2004; 95(6): 554 - 556. [Full Text] [PDF]
|
|
|
|
|
|
A. Khoynezhad, Z. Jalali, and A. J. Tortolani Apoptosis: Pathophysiology and therapeutic implications for the cardiac surgeon Ann. Thorac. Surg., September 1, 2004; 78(3): 1109 - 1118. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Engel, R. Peshock, R. C. Armstong, N. Sivasubramanian, and D. L. Mann Cardiac myocyte apoptosis provokes adverse cardiac remodeling in transgenic mice with targeted TNF overexpression Am J Physiol Heart Circ Physiol, September 1, 2004; 287(3): H1303 - H1311. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Ramani, M. Mathier, P. Wang, G. Gibson, S. Togel, J. Dawson, A. Bauer, S. Alber, S. C. Watkins, C. F. McTiernan, et al. Inhibition of tumor necrosis factor receptor-1-mediated pathways has beneficial effects in a murine model of postischemic remodeling Am J Physiol Heart Circ Physiol, September 1, 2004; 287(3): H1369 - H1377. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sekiguchi, X. Li, M. Coker, M. Flesch, P. M Barger, N. Sivasubramanian, and D. L Mann Cross-regulation between the renin-angiotensin system and inflammatory mediators in cardiac hypertrophy and failure Cardiovasc Res, August 15, 2004; 63(3): 433 - 442. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Berthonneche, T. Sulpice, F. Boucher, L. Gouraud, J. de Leiris, S. E. O'Connor, J.-M. Herbert, and P. Janiak New insights into the pathological role of TNF-{alpha} in early cardiac dysfunction and subsequent heart failure after infarction in rats Am J Physiol Heart Circ Physiol, July 1, 2004; 287(1): H340 - H350. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nian, P. Lee, N. Khaper, and P. Liu Inflammatory Cytokines and Postmyocardial Infarction Remodeling Circ. Res., June 25, 2004; 94(12): 1543 - 1553. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M Janczewski, M. Zahid, B. H Lemster, C. S Frye, G. Gibson, Y. Higuchi, E. G Kranias, A. M Feldman, and C. F McTiernan Phospholamban gene ablation improves calcium transients but not cardiac function in a heart failure model Cardiovasc Res, June 1, 2004; 62(3): 468 - 480. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Higuchi, C. F. McTiernan, C. B. Frye, B. S. McGowan, T. O. Chan, and A. M. Feldman Tumor Necrosis Factor Receptors 1 and 2 Differentially Regulate Survival, Cardiac Dysfunction, and Remodeling in Transgenic Mice With Tumor Necrosis Factor-{alpha}-Induced Cardiomyopathy Circulation, April 20, 2004; 109(15): 1892 - 1897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Mann, J. J.V. McMurray, M. Packer, K. Swedberg, J. S. Borer, W. S. Colucci, J. Djian, H. Drexler, A. Feldman, L. Kober, et al. Targeted Anticytokine Therapy in Patients With Chronic Heart Failure: Results of the Randomized Etanercept Worldwide Evaluation (RENEWAL) Circulation, April 6, 2004; 109(13): 1594 - 1602. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Tsutamoto, A. Wada, M. Ohnishi, T. Tsutsui, C. Ishii, K. Ohno, M. Fujii, T. Matsumoto, T. Yamamoto, T. Takayama, et al. Transcardiac increase in tumor necrosis factor-{alpha} and left ventricular end-diastolic volume in patients with dilated cardiomyopathy Eur J Heart Fail, March 1, 2004; 6(2): 173 - 180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. V. Finsen, P. R. Woldbaek, J. Li, J. Wu, T. Lyberg, T. Tonnessen, and G. Christensen Increased syndecan expression following myocardial infarction indicates a role in cardiac remodeling Physiol Genomics, February 13, 2004; 16(3): 301 - 308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. P. Soares, R. S. Lima, L. L. Rocha, C. M. Takyia, L. Pontes-de-Carvalho, A. C. Campos de Carvalho, and R. Ribeiro-dos-Santos Transplanted Bone Marrow Cells Repair Heart Tissue and Reduce Myocarditis in Chronic Chagasic Mice Am. J. Pathol., February 1, 2004; 164(2): 441 - 447. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Wang, H. R. Brunner, and M. Burnier Determination of cardiac contractility in awake unsedated mice with a fluid-filled catheter Am J Physiol Heart Circ Physiol, February 1, 2004; 286(2): H806 - H814. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Feldman The emerging role of pharmacogenomics in the treatment of patients with heart failure Ann. Thorac. Surg., December 1, 2003; 76(6): S2246 - 2253. [Full Text] [PDF]
|
|
|
|
 |
|
 J. F. Elliott, J. Liu, Z.-N. Yuan, N. Bautista-Lopez, S. L. Wallbank, K. Suzuki, D. Rayner, P. Nation, M. A. Robertson, G. Liu, et al. Autoimmune cardiomyopathy and heart block develop spontaneously in HLA-DQ8 transgenic IA{beta} knockout NOD mice PNAS, November 11, 2003; 100(23): 13447 - 13452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Jacoby, A. Kalinowski, M.-G. Liu, S. S.-M. Zhang, Q. Gao, G.-X. Chai, L. Ji, Y. Iwamoto, E. Li, M. Schneider, et al. Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age PNAS, October 28, 2003; 100(22): 12929 - 12934. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Tomasdottir, H. Hjartarson, A. Ricksten, C. Wasslavik, A. Bengtsson, and S.-E. Ricksten Tumor Necrosis Factor Gene Polymorphism Is Associated with Enhanced Systemic Inflammatory Response and Increased Cardiopulmonary Morbidity After Cardiac Surgery Anesth. Analg., October 1, 2003; 97(4): 944 - 949. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. I. Dibbs, A. Diwan, S. Nemoto, G. DeFreitas, M. Abdellatif, B. A. Carabello, F. G. Spinale, G. Feuerstein, N. Sivasubramanian, and D. L. Mann Targeted Overexpression of Transmembrane Tumor Necrosis Factor Provokes a Concentric Cardiac Hypertrophic Phenotype Circulation, August 26, 2003; 108(8): 1002 - 1008. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Flesch, A. Hoper, L. Dell'Italia, K. Evans, R. Bond, R. Peshock, A. Diwan, T. A. Brinsa, C.-C. Wei, N. Sivasubramanian, et al. Activation and Functional Significance of the Renin-Angiotensin System in Mice With Cardiac Restricted Overexpression of Tumor Necrosis Factor Circulation, August 5, 2003; 108(5): 598 - 604. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. He, Y. Liu, V. Sharma, R. T. Dirksen, R. Waugh, S.-S. Sheu, and W. Min ASK1 Associates with Troponin T and Induces Troponin T Phosphorylation and Contractile Dysfunction in Cardiomyocytes Am. J. Pathol., July 1, 2003; 163(1): 243 - 251. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. S. Chung, M. Packer, K. H. Lo, A. A. Fasanmade, and J. T. Willerson Randomized, Double-Blind, Placebo-Controlled, Pilot Trial of Infliximab, a Chimeric Monoclonal Antibody to Tumor Necrosis Factor-{alpha}, in Patients With Moderate-to-Severe Heart Failure: Results of the Anti-TNF Therapy Against Congestive Heart failure (ATTACH) Trial Circulation, July 1, 2003; 107(25): 3133 - 3140. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. J. Kwon, T. R. Cote, M. S. Cuffe, J. M. Kramer, and M M. Braun Case Reports of Heart Failure after Therapy with a Tumor Necrosis Factor Antagonist Ann Intern Med, May 20, 2003; 138(10): 807 - 811. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Murray and G. L. Freeman Proinflammatory Cytokines: Predictors of a Failing Heart? Circulation, March 25, 2003; 107(11): 1460 - 1462. [Full Text] [PDF]
|
|
|
|
 |
|
 H. A. Malave, A. A. Taylor, J. Nattama, A. Deswal, and D. L. Mann Circulating Levels of Tumor Necrosis Factor Correlate With Indexes of Depressed Heart Rate Variability: A Study in Patients With Mild-to-Moderate Heart Failure Chest, March 1, 2003; 123(3): 716 - 724. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Oral, N. Sivasubramanian, D. B. Dyke, R. H. Mehta, P. M. Grossman, K. Briesmiester, W. P. Fay, F. D. Pagani, S. F. Bolling, D. L. Mann, et al. Myocardial Proinflammatory Cytokine Expression and Left Ventricular Remodeling in Patients With Chronic Mitral Regurgitation Circulation, February 18, 2003; 107(6): 831 - 837. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. London, L. C. Baker, J. S. Lee, V. Shusterman, B.-R. Choi, T. Kubota, C. F. McTiernan, A. M. Feldman, and G. Salama Calcium-dependent arrhythmias in transgenic mice with heart failure Am J Physiol Heart Circ Physiol, February 1, 2003; 284(2): H431 - H441. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Machida, T. Kubota, N. Kawamura, H. Funakoshi, T. Ide, H. Utsumi, Y. Y. Li, A. M. Feldman, H. Tsutsui, H. Shimokawa, et al. Overexpression of tumor necrosis factor-alpha increases production of hydroxyl radical in murine myocardium Am J Physiol Heart Circ Physiol, February 1, 2003; 284(2): H449 - H455. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Brutsaert Cardiac Endothelial-Myocardial Signaling: Its Role in Cardiac Growth, Contractile Performance, and Rhythmicity Physiol Rev, January 1, 2003; 83(1): 59 - 115. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P A Henriksen and D E Newby Therapeutic inhibition of tumour necrosis factor {alpha} in patients with heart failure: cooling an inflamed heart Heart, January 1, 2003; 89(1): 14 - 18. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Steenbergen, C. A. Afshari, J. G. Petranka, J. Collins, K. Martin, L. Bennett, A. Haugen, P. Bushel, and E. Murphy Alterations in apoptotic signaling in human idiopathic cardiomyopathic hearts in failure Am J Physiol Heart Circ Physiol, January 1, 2003; 284(1): H268 - H276. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Afanasyeva and N.R. Rose Immune mediators in inflammatory heart disease: insights from a mouse model Eur. Heart J. Suppl., December 1, 2002; 4(suppl_I): I31 - I36. [Abstract] [PDF]
|
|
|
|
|
|
S.B. Felix, A. Staudt, and G. Baumann Immunoadsorption as a new therapeutic principle for treatment of dilated cardiomyopathy Eur. Heart J. Suppl., December 1, 2002; 4(suppl_I): I63 - I68. [Abstract] [PDF]
|
|
|
|
|
|
L. Fernandez-Celemin, N. Pasko, V. Blomart, and J.-P. Thissen Inhibition of muscle insulin-like growth factor I expression by tumor necrosis factor-alpha Am J Physiol Endocrinol Metab, December 1, 2002; 283(6): E1279 - E1290. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Mann Inflammatory Mediators and the Failing Heart: Past, Present, and the Foreseeable Future Circ. Res., November 29, 2002; 91(11): 988 - 998. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. C. Brum, J. Kosek, A. Patterson, D. Bernstein, and B. Kobilka Abnormal cardiac function associated with sympathetic nervous system hyperactivity in mice Am J Physiol Heart Circ Physiol, November 1, 2002; 283(5): H1838 - H1845. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M Smith, S. Lecour, and M. N Sack Innate immunity and cardiac preconditioning: a putative intrinsic cardioprotective program Cardiovasc Res, August 15, 2002; 55(3): 474 - 482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M Smith, N. Suleman, J. McCarthy, and M. N Sack Classic ischemic but not pharmacologic preconditioning is abrogated following genetic ablation of the TNF{alpha} gene Cardiovasc Res, August 15, 2002; 55(3): 553 - 560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. L. Li, J. Suzuki, E. Bayna, F.-M. Zhang, E. Dalle Molle, A. Clark, R. L. Engler, and W. Y. W. Lew Lipopolysaccharide induces apoptosis in adult rat ventricular myocytes via cardiac AT1 receptors Am J Physiol Heart Circ Physiol, August 1, 2002; 283(2): H461 - H467. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Afanasyeva and N. R. Rose Cardiomyopathy Is Linked to Complement Activation Am. J. Pathol., August 1, 2002; 161(2): 351 - 357. [Full Text] [PDF]
|
|
|
|
|
|
T. P. Zwaka, D. Manolov, C. Ozdemir, N. Marx, Z. Kaya, M. Kochs, M. Hoher, V. Hombach, and J. Torzewski Complement and Dilated Cardiomyopathy: A Role of Sublytic Terminal Complement Complex-Induced Tumor Necrosis Factor-{alpha} Synthesis in Cardiac Myocytes Am. J. Pathol., August 1, 2002; 161(2): 449 - 457. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Shusterman, I. Usiene, C. Harrigal, J. S. Lee, T. Kubota, A. M. Feldman, and B. London Strain-specific patterns of autonomic nervous system activity and heart failure susceptibility in mice Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H2076 - H2083. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Funakoshi, T. Kubota, Y. Machida, N. Kawamura, A. M. Feldman, H. Tsutsui, H. Shimokawa, and A. Takeshita Involvement of inducible nitric oxide synthase in cardiac dysfunction with tumor necrosis factor-alpha Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H2159 - H2166. [Abstract] [Full Text] [PDF]
|
|