© 1997 American Heart Association, Inc.
Articles |
Angiotensin II Signal Transduction in Vascular Smooth Muscle
Role of Tyrosine Kinases
From the University of Washington, Department of Medicine, Cardiology Division, Seattle.
Correspondence to Bradford C. Berk, MD, PhD, University of Washington, Department of Medicine, Mail Stop 357710, Seattle, WA 98195. E-mail bcberk{at}u.washington.edu
Abstract In this review, the role of tyrosine kinases in
angiotensin II–mediated signal transduction pathways in
vascular smooth muscle is discussed. Angiotensin II was
isolated by virtue of its vasoconstrictor abilities and has long been
thought to play a critical role in hypertension. However, recent
studies indicate important roles for angiotensin II in
inflammation, atherosclerosis, and congestive heart
failure. The expanding role of angiotensin II indicates
that multiple signal transduction pathways are likely to be
activated in a tissue-specific manner. Exciting recent data
show that angiotensin II directly stimulates tyrosine
kinases, including pp60c-src kinase (c-Src), focal adhesion
kinase (FAK), and Janus kinases (JAK2 and TYK2).
Angiotensin II may activate receptor tyrosine
kinases, such as Axl and platelet-derived growth factor, by
as-yet-undefined autocrine mechanisms. Finally, unknown tyrosine
kinases may mediate tyrosine phosphorylation of Shc,
Raf, and phospholipase C-
after angiotensin II
stimulation. These angiotensin II–regulated tyrosine
kinases appear to be required for angiotensin II effects,
such as vasoconstriction, proto-oncogene expression, and protein
synthesis, on the basis of studies with tyrosine kinase
inhibitors. Thus, understanding angiotensin
II–stimulated signaling events, especially those related to tyrosine
kinase activity, may form the basis for the development of new
therapies for cardiovascular diseases.
Key Words: tyrosine kinase • signal transduction • Src • focal adhesion kinase • platelet-derived growth factor
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X.-P. Xi, K. Graf, S. Goetze, E. Fleck, W. A. Hsueh, and R. E. Law Central Role of the MAPK Pathway in Ang II–Mediated DNA Synthesis and Migration in Rat Vascular Smooth Muscle Cells Arterioscler Thromb Vasc Biol, January 1, 1999; 19(1): 73 - 82. [Abstract] [Full Text] [PDF]
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S. Eguchi, H. Iwasaki, T. Inagami, K. Numaguchi, T. Yamakawa, E. D. Motley, K. M. Owada, F. Marumo, and Y. Hirata Involvement of PYK2 in Angiotensin II Signaling of Vascular Smooth Muscle Cells Hypertension, January 1, 1999; 33(1): 201 - 206. [Abstract] [Full Text] [PDF]
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T. Inagami A Memorial to Robert Tiegerstedt : The Centennial of Renin Discovery Hypertension, December 1, 1998; 32(6): 953 - 957. [Full Text] [PDF]
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M. Kusuhara, E. Takahashi, T. E. Peterson, J.-i. Abe, M. Ishida, J. Han, R. Ulevitch, and B. C. Berk p38 Kinase Is a Negative Regulator of Angiotensin II Signal Transduction in Vascular Smooth Muscle Cells : Effects on Na+/H+ Exchange and ERK1/2 Circ. Res., October 19, 1998; 83(8): 824 - 831. [Abstract] [Full Text] [PDF]
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A. Sabri, G. Govindarajan, T. M. Griffin, K. L. Byron, A. M. Samarel, and P. A. Lucchesi Calcium- and Protein Kinase C–Dependent Activation of the Tyrosine Kinase PYK2 by Angiotensin II in Vascular Smooth Muscle Circ. Res., October 19, 1998; 83(8): 841 - 851. [Abstract] [Full Text] [PDF]
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K. Tamura, N. Nyui, N. Tamura, T. Fujita, M. Kihara, Y. Toya, I. Takasaki, N. Takagi, M. Ishii, K.-i. Oda, et al. Mechanism of Angiotensin II-mediated Regulation of Fibronectin Gene in Rat Vascular Smooth Muscle Cells J. Biol. Chem., October 9, 1998; 273(41): 26487 - 26496. [Abstract] [Full Text] [PDF]
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M. G. Melaragno, D. A. Wuthrich, V. Poppa, D. Gill, V. Lindner, B. C. Berk, and M. A. Corson Increased Expression of Axl Tyrosine Kinase After Vascular Injury and Regulation by G Protein–Coupled Receptor Agonists in Rats Circ. Res., October 5, 1998; 83(7): 697 - 704. [Abstract] [Full Text] [PDF]
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S. Murasawa, Y. Mori, Y. Nozawa, H. Masaki, K. Maruyama, Y. Tsutsumi, Y. Moriguchi, Y. Shibasaki, Y. Tanaka, T. Iwasaka, et al. Role of Calcium-Sensitive Tyrosine Kinase Pyk2/CAKß/RAFTK in Angiotensin II–Induced Ras/ERK Signaling Hypertension, October 1, 1998; 32(4): 668 - 675. [Abstract] [Full Text] [PDF]
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S. W. Watts, J. A. Florian, and K. M. Monroe Dissociation of Angiotensin II-Stimulated Activation of Mitogen-Activated Protein Kinase Kinase from Vascular Contraction J. Pharmacol. Exp. Ther., September 1, 1998; 286(3): 1431 - 1438. [Abstract] [Full Text]
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U. Schmitz, T. Ishida, M. Ishida, J. Surapisitchat, M. I. Hasham, S. Pelech, and B. C. Berk Angiotensin II Stimulates p21-Activated Kinase in Vascular Smooth Muscle Cells : Role in Activation of JNK Circ. Res., June 29, 1998; 82(12): 1272 - 1278. [Abstract] [Full Text] [PDF]
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S. Murasawa, Y. Mori, Y. Nozawa, N. Gotoh, M. Shibuya, H. Masaki, K. Maruyama, Y. Tsutsumi, Y. Moriguchi, Y. Shibazaki, et al. Angiotensin II Type 1 Receptor–Induced Extracellular Signal–Regulated Protein Kinase Activation Is Mediated by Ca2+/Calmodulin-Dependent Transactivation of Epidermal Growth Factor Receptor Circ. Res., June 29, 1998; 82(12): 1338 - 1348. [Abstract] [Full Text] [PDF]
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J. Sadoshima Versatility of the Angiotensin II Type 1 Receptor Circ. Res., June 29, 1998; 82(12): 1352 - 1355. [Full Text] [PDF]
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H. Aoki, S. Izumo, and J. Sadoshima Angiotensin II Activates RhoA in Cardiac Myocytes : A Critical Role of RhoA in Angiotensin II–Induced Premyofibril Formation Circ. Res., April 6, 1998; 82(6): 666 - 676. [Abstract] [Full Text] [PDF]
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B. Fisslthaler, V. B Schini-Kerth, I. Fleming, and R. Busse Thrombin receptor expression is increased by angiotensin II in cultured and native vascular smooth muscle cells Cardiovasc Res, April 1, 1998; 38(1): 263 - 271. [Abstract] [Full Text] [PDF]
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T. Kitazono, S. Ibayashi, T. Nagao, T. Kagiyama, J. Kitayama, M. Fujishima, and F. M. Faraci Role of Tyrosine Kinase in Serotonin-Induced Constriction of the Basilar Artery In Vivo • Editorial Comment Stroke, February 1, 1998; 29(2): 494 - 498. [Abstract] [Full Text] [PDF]
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M. van Bilsen Signal transduction revisited: recent developments in angiotensin II signaling in the cardiovascular system Cardiovasc Res, December 1, 1997; 36(3): 310 - 322. [Full Text] [PDF]
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M. S. Ali, P. P. Sayeski, L. B. Dirksen, D. J. Hayzer, M. B. Marrero, and K. E. Bernstein Dependence on the Motif YIPP for the Physical Association of Jak2 Kinase with the Intracellular Carboxyl Tail of the Angiotensin II AT1 Receptor J. Biol. Chem., September 12, 1997; 272(37): 23382 - 23388. [Abstract] [Full Text] [PDF]
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L. Guillemot, A. Levy, Z. J. Zhao, G. Bereziat, and B. Rothhut The Protein-tyrosine Phosphatase SHP-2 Is Required during Angiotensin II-mediated Activation of Cyclin D1 Promoter in CHO-AT1A Cells J. Biol. Chem., August 18, 2000; 275(34): 26349 - 26358. [Abstract] [Full Text] [PDF]
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P. Rocic and P. A. Lucchesi Down-regulation by Antisense Oligonucleotides Establishes a Role for the Proline-rich Tyrosine Kinase PYK2 in Angiotensin II-induced Signaling in Vascular Smooth Muscle J. Biol. Chem., June 8, 2001; 276(24): 21902 - 21906. [Abstract] [Full Text] [PDF]
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S. Murasawa, H. Matsubara, Y. Mori, H. Masaki, Y. Tsutsumi, Y. Shibasaki, I. Kitabayashi, Y. Tanaka, S. Fujiyama, Y. Koyama, et al. Angiotensin II Initiates Tyrosine Kinase Pyk2-dependent Signalings Leading to Activation of Rac1-mediated c-Jun NH2-terminal Kinase J. Biol. Chem., August 25, 2000; 275(35): 26856 - 26863. [Abstract] [Full Text] [PDF]
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