© 1996 American Heart Association, Inc.
Articles |
Sustained Increase in Aortic Endothelial Nitric Oxide Synthase Expression In Vivo in a Model of Chronic High Blood Flow
INSERM U 358 (S.N., F.S.), Hopital Saint Louis, and INSERM U 367 (M.P., J.-F.A., J.-B.M.), Paris, France.
Correspondence to F. Soubrier, INSERM U 358, Hopital Saint Louis, 1 av Claude Vellefaux 75475 Paris Cedex 10, France.
Physiological adaptation of normal blood vessels to acute or chronic changes in blood flow is endothelium dependent. In vitro studies have shown that, among other genes, NO synthase (NOS) 3 mRNA and protein expression is enhanced by acute elevation of shear stress in endothelial cells. We have investigated the effect of chronic high blood flow on NOS3 mRNA and protein expression in rat aorta. NOS3 mRNA levels were measured by quantitative polymerase chain reaction (PCR) in the aortas of 12 rats with arteriovenous fistulas and 9 sham-operated control rats. The PCR assay indicated that NOS3 mRNA levels were significantly enhanced (twofold) during high blood flow. Western blots showed that immunoreactive NOS3 levels were also increased to a similar extent. Furthermore, the Ca2+-dependent NOS activity, measured by the L-arginine to L-citrulline conversion assay, and the cGMP content were also significantly increased in the proximal aortic wall submitted to the arteriovenous shunt. These results indicate that NOS3 mRNA and protein expression is enhanced in vivo during chronic high blood flow.
Key Words: NOS3 mRNA • shear stress • gene expression • aortocaval fistula
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C. R. Woodman, J. M. Muller, M. H. Laughlin, and E. M. Price Induction of nitric oxide synthase mRNA in coronary resistance arteries isolated from exercise-trained pigs Am J Physiol Heart Circ Physiol, December 1, 1997; 273(6): H2575 - H2579. [Abstract] [Full Text] [PDF]
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M. Challah, S. Nadaud, M. Philippe, T. Battle, F. Soubrier, B. Corman, and J. B. Michel Circulating and cellular markers of endothelial dysfunction with aging in rats Am J Physiol Heart Circ Physiol, October 1, 1997; 273(4): H1941 - H1948. [Abstract] [Full Text] [PDF]
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J. K. Miyashiro, V. Poppa, and B. C. Berk Flow-Induced Vascular Remodeling in the Rat Carotid Artery Diminishes With Age Circ. Res., September 19, 1997; 81(3): 311 - 319. [Abstract] [Full Text]
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J. L. Parker, M. L. Mattox, and M. H. Laughlin Contractile responsiveness of coronary arteries from exercise-trained rats J Appl Physiol, August 1, 1997; 83(2): 434 - 443. [Abstract] [Full Text] [PDF]
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K. Cieslik, C. S. Abrams, and K. K. Wu Up-regulation of Endothelial Nitric-oxide Synthase Promoter by the Phosphatidylinositol 3-Kinase gamma /Janus Kinase 2/MEK-1-dependent Pathway J. Biol. Chem., January 5, 2001; 276(2): 1211 - 1219. [Abstract] [Full Text] [PDF]
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