© 1996 American Heart Association, Inc.
Articles |
Role of the Kv4.3 K+ Channel in Ventricular Muscle
A Molecular Correlate for the Transient Outward Current
the Department of Neurobiology and Behavior and Department of Physiology and Biophysics, State University of New York at Stony Brook.
Correspondence to Dr David McKinnon, Department of Neurobiology and Behavior, State University of New York at Stony Brook, Stony Brook, NY 11794-5230.
The expression of 15 different K+ channels in canine heart was examined, and a new K+ channel gene (Kv4.3), which encodes a rapidly inactivating K+ current, is described. The Kv4.3 channel was found to have biophysical and pharmacological properties similar to the native canine transient outward current (Ito). The Kv4.3 gene is also expressed in human and rat heart. It is concluded that the Kv4.3 channel underlies the bulk of the Ito in canine ventricular myocytes, and probably in human myocytes. Both the Kv4.3 and Kv4.2 channels are likely to contribute to the Ito in rat heart, and differential expression of these two channels can account for observed differences in the kinetic properties of the Ito in different regions of rat ventricle. There are significant differences in the pattern of K+ channel expression in canine heart, compared with rat heart, and these differences may be an adaptation to the different requirements for cardiac function in mammals of markedly different sizes. It is possible that the much longer ventricular action potential duration observed in canine heart compared with rat heart is due, in part, to the lower levels of Kv1.2, Kv2.1, and Kv4.2 gene expression in canine heart.
Key Words: K+ channel • cardiac muscle • mRNA expression • transient outward current
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B. Rosati, Z. Pan, S. Lypen, H.-S. Wang, I. Cohen, J. E Dixon, and D. McKinnon Regulation of KChIP2 potassium channel {beta} subunit gene expression underlies the gradient of transient outward current in canine and human ventricle J. Physiol., May 15, 2001; 533(1): 119 - 125. [Abstract] [Full Text] [PDF]
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T. González, M. Longobardo, R. Caballero, E. Delpón, J. Tamargo, and C. Valenzuela Effects of Bupivacaine and a Novel Local Anesthetic, IQB-9302, on Human Cardiac K+ Channels J. Pharmacol. Exp. Ther., April 13, 2001; 296(2): 573 - 583. [Abstract] [Full Text]
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 K. N. Jew, M. C. Olsson, E. A. Mokelke, B. M. Palmer, and R. L. Moore Endurance training alters outward K+ current characteristics in rat cardiocytes J Appl Physiol, April 1, 2001; 90(4): 1327 - 1333. [Abstract] [Full Text] [PDF]
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 R. Caballero, E. Delpón, C. Valenzuela, M. Longobardo, T. González, and J. Tamargo Direct Effects of Candesartan and Eprosartan on Human Cloned Potassium Channels Involved in Cardiac Repolarization Mol. Pharmacol., April 1, 2001; 59(4): 825 - 836. [Abstract] [Full Text]
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T.-T. Zhang, K. Takimoto, A. F. R. Stewart, C. Zhu, and E. S. Levitan Independent Regulation of Cardiac Kv4.3 Potassium Channel Expression by Angiotensin II and Phenylephrine Circ. Res., March 16, 2001; 88(5): 476 - 482. [Abstract] [Full Text] [PDF]
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 B. J. J. M. Brundel, I. C. Van Gelder, R. H. Henning, A. E. Tuinenburg, M. Wietses, J. G. Grandjean, A. A. M. Wilde, W. H. Van Gilst, and H. J. G. M. Crijns Alterations in potassium channel gene expression in atria of patients with persistent and paroxysmal atrial fibrillation: differential regulation of protein and mRNA levels for K+ channels J. Am. Coll. Cardiol., March 1, 2001; 37(3): 926 - 932. [Abstract] [Full Text] [PDF]
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 C.-C. Shieh, M. Coghlan, J. P. Sullivan, and M. Gopalakrishnan Potassium Channels: Molecular Defects, Diseases, and Therapeutic Opportunities Pharmacol. Rev., December 1, 2000; 52(4): 557 - 594. [Abstract] [Full Text] [PDF]
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J. L. Greenstein, R. Wu, S. Po, G. F. Tomaselli, and R. L. Winslow Role of the Calcium-Independent Transient Outward Current Ito1 in Shaping Action Potential Morphology and Duration Circ. Res., November 24, 2000; 87(11): 1026 - 1033. [Abstract] [Full Text] [PDF]
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L. Yue, Z. Wang, H. Rindt, and S. Nattel Molecular evidence for a role of Shaw (Kv3) potassium channel subunits in potassium currents of dog atrium J. Physiol., September 15, 2000; 527(3): 467 - 478. [Abstract] [Full Text] [PDF]
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H. Wang, H. Shi, L. Zhang, M. Pourrier, B. Yang, S. Nattel, and Z. Wang Nicotine Is a Potent Blocker of the Cardiac A-Type K+ Channels : Effects on Cloned Kv4.3 Channels and Native Transient Outward Current Circulation, September 5, 2000; 102(10): 1165 - 1171. [Abstract] [Full Text] [PDF]
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I. C.-H. Yang, M. W. Scherz, A. Bahinski, P. B. Bennett, and K. T. Murray Stereoselective Interactions of the Enantiomers of Chromanol 293B with Human Voltage-Gated Potassium Channels J. Pharmacol. Exp. Ther., September 1, 2000; 294(3): 955 - 962. [Abstract] [Full Text]
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W. Han, Z. Wang, and S. Nattel A comparison of transient outward currents in canine cardiac Purkinje cells and ventricular myocytes Am J Physiol Heart Circ Physiol, August 1, 2000; 279(2): H466 - H474. [Abstract] [Full Text] [PDF]
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 H. Dobrzynski, S. M. Rothery, D. D.R. Marples, S. R. Coppen, Y. Takagishi, H. Honjo, M. M. Tamkun, Z. Henderson, I. Kodama, N. J. Severs, et al. Presence of the Kv1.5 K+ Channel in the Sinoatrial Node J. Histochem. Cytochem., June 1, 2000; 48(6): 769 - 780. [Abstract] [Full Text]
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J. M Nerbonne Molecular basis of functional voltage-gated K+ channel diversity in the mammalian myocardium J. Physiol., June 1, 2000; 525(2): 285 - 298. [Abstract] [Full Text] [PDF]
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M. Lei, H. Honjo, I. Kodama, and M.R. Boyett Characterisation of the transient outward K+ current in rabbit sinoatrial node cells Cardiovasc Res, June 1, 2000; 46(3): 433 - 441. [Abstract] [Full Text] [PDF]
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H. Yu, J. Gao, H. Wang, R. Wymore, S. Steinberg, D. McKinnon, M. R. Rosen, and I. S. Cohen Effects of the Renin-Angiotensin System on the Current Ito in Epicardial and Endocardial Ventricular Myocytes From the Canine Heart Circ. Res., May 26, 2000; 86(10): 1062 - 1068. [Abstract] [Full Text] [PDF]
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H. Abriel, H. Motoike, and R. S. Kass KChAP: a novel chaperone for specific K+ channels key to repolarization of the cardiac action potential. Focus on "KChAP as a chaperone for specific K+ channels" Am J Physiol Cell Physiol, May 1, 2000; 278(5): C863 - C864. [Full Text] [PDF]
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Y. A. Kuryshev, T. I. Gudz, A. M. Brown, and B. A. Wible KChAP as a chaperone for specific K+ channels Am J Physiol Cell Physiol, May 1, 2000; 278(5): C931 - C941. [Abstract] [Full Text] [PDF]
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T. Yamashita, Y. Murakawa, N. Hayami, E.-i. Fukui, Y. Kasaoka, M. Inoue, and M. Omata Short-Term Effects of Rapid Pacing on mRNA Level of Voltage-Dependent K+ Channels in Rat Atrium : Electrical Remodeling in Paroxysmal Atrial Tachycardia Circulation, April 25, 2000; 101(16): 2007 - 2014. [Abstract] [Full Text] [PDF]
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A. D. Wickenden, R. Kaprielian, X.-M. You, and P. H. Backx The thyroid hormone analog DITPA restores Ito in rats after myocardial infarction Am J Physiol Heart Circ Physiol, April 1, 2000; 278(4): H1105 - H1116. [Abstract] [Full Text] [PDF]
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S. Nattel, C. Matthews, E. De Blasio, W. Han, D. Li, and L. Yue Dose-Dependence of 4-Aminopyridine Plasma Concentrations and Electrophysiological Effects in Dogs : Potential Relevance to Ionic Mechanisms In Vivo Circulation, March 14, 2000; 101(10): 1179 - 1184. [Abstract] [Full Text] [PDF]
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H. Shi, H.-Z. Wang, and Z. Wang Extracellular Ba2+ blocks the cardiac transient outward K+ current Am J Physiol Heart Circ Physiol, January 1, 2000; 278(1): H295 - H299. [Abstract] [Full Text] [PDF]
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J.-K. Lee, A. Nishiyama, F. Kambe, H. Seo, S. Takeuchi, K. Kamiya, I. Kodama, and J. Toyama Downregulation of voltage-gated K+ channels in rat heart with right ventricular hypertrophy Am J Physiol Heart Circ Physiol, November 1, 1999; 277(5): H1725 - H1731. [Abstract] [Full Text] [PDF]
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J.-A. Yao, M. Jiang, J.-S. Fan, Y.-Y. Zhou, and G.-N. Tseng Heterogeneous changes in K currents in rat ventricles three days after myocardial infarction Cardiovasc Res, October 1, 1999; 44(1): 132 - 145. [Abstract] [Full Text] [PDF]
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H. Xu, H. Li, and J. M Nerbonne Elimination of the transient outward current and action potential prolongation in mouse atrial myocytes expressing a dominant negative Kv4 {alpha} subunit J. Physiol., August 15, 1999; 519(1): 11 - 21. [Abstract] [Full Text] [PDF]
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W. Shi, R. Wymore, H. Yu, J. Wu, R. T. Wymore, Z. Pan, R. B. Robinson, J. E. Dixon, D. McKinnon, and I. S. Cohen Distribution and Prevalence of Hyperpolarization-Activated Cation Channel (HCN) mRNA Expression in Cardiac Tissues Circ. Res., July 9, 1999; 85 (1): e1 - e6. [Abstract] [Full Text] [PDF]
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E. Carmeliet Cardiac Ionic Currents and Acute Ischemia: From Channels to Arrhythmias Physiol Rev, July 1, 1999; 79(3): 917 - 1017. [Abstract] [Full Text] [PDF]
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H. M. Himmel, E. Wettwer, Q. Li, and U. Ravens Four different components contribute to outward current in rat ventricular myocytes Am J Physiol Heart Circ Physiol, July 1, 1999; 277(1): H107 - H118. [Abstract] [Full Text] [PDF]
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E. Bou-Abboud and J. M Nerbonne Molecular correlates of the calcium-independent, depolarization-activated K+ currents in rat atrial myocytes J. Physiol., June 1, 1999; 517(2): 407 - 420. [Abstract] [Full Text] [PDF]
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