© 1995 American Heart Association, Inc.
Articles |
Role of Bradykinin in Protection of Ischemic Preconditioning in Rabbit Hearts
From the Departments of Medicine (M.V.C.) and Physiology, University of South Alabama, College of Medicine, Mobile.
Correspondence to Michael V. Cohen, MD, Department of Physiology, MSB 3050, University of South Alabama, College of Medicine, Mobile, AL 36688.
Abstract Bradykinin receptor activation has been proposed to
be involved in ischemic preconditioning. In the present
study, we further investigated the role of this agent in
preconditioning in both isolated and in situ rabbit hearts. All hearts
were subjected to 30 minutes of regional ischemia followed by
reperfusion for 2 hours (in vitro hearts) and 3 hours (in situ hearts).
Infarct size was measured by tetrazolium staining and expressed as a
percentage of the size of the risk zone. Preconditioning in situ hearts
with 5 minutes of ischemia and 10 minutes of reperfusion
significantly reduced infarct size to 10.2±2.2% of the risk region
(P<.0005 versus control infarct size of 36.7±2.6%).
Pretreatment with HOE 140 (26 µg/kg), a bradykinin B2
receptor blocker, did not alter infarct size in
nonpreconditioned hearts (40.6±5.3% infarction) but
abolished protection from ischemic preconditioning (34.1±1.6%
infarction). However, when HOE 140 was administered during the initial
reflow period following 5 minutes of ischemia, protection was
no longer abolished (15.6±3.9% infarction versus 13.3±3.8% without
HOE 140, P=NS). Bradykinin infusion in isolated hearts
mimicked preconditioning, and protection was not affected by
pretreatment with the nitric oxide synthase inhibitor
N
-nitro-L-arginine methyl ester
or the prostaglandin synthesis inhibitor
indomethacin but could be completely abolished by the
protein kinase C (PKC) inhibitors polymyxin B and
staurosporine as well as by HOE 140. HOE 140 could not
block the protection of ischemic preconditioning in isolated
hearts. That failure was apparently due to the absence of blood-borne
kininogens rather than autonomic nerves. When the preconditioning
stimulus in the in situ model was amplified with four cycles of
5-minute ischemia/10-minute reperfusion, HOE 140 pretreatment
could no longer block protection (infarct size was 10.7±3.5% versus
6.4±2.0% without HOE 140, P=NS). We propose that
bradykinin receptors protect by coupling to PKC as do adenosine
receptors, and blockade of either receptor will diminish the total
stimulus of PKC below threshold and prevent protection. A more intense
preconditioning ischemic stimulus can overcome bradykinin
receptor blockade, however, by simply enhancing the amount of
adenosine and possibly other agonists released.
Key Words: adenosine • bradykinin • ischemic preconditioning • HOE 140 • protein kinase C
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|
|
|
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|
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|
|
|
|
|
|
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|
|
|
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|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
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|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 D M Yellon and G F Baxter Protecting the ischaemic and reperfused myocardium in acute myocardial infarction: distant dream or near reality? Heart, April 1, 2000; 83(4): 381 - 387. [Full Text]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
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|
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L. P. Perrault and P. Menasche Preconditioning: can nature’s shield be raised against surgical ischemic-reperfusion injury? Ann. Thorac. Surg., November 1, 1999; 68(5): 1988 - 1994. [Abstract] [Full Text] [PDF]
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T. Okamura, T. Miura, H. Iwamoto, K. Shirakawa, S. Kawamura, Y. Ikeda, M. Iwatate, and M. Matsuzaki Ischemic preconditioning attenuates apoptosis through protein kinase C in rat hearts Am J Physiol Heart Circ Physiol, November 1, 1999; 277(5): H1997 - H2001. [Abstract] [Full Text] [PDF]
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M. A. Leesar, M. F. Stoddard, S. Manchikalapudi, and R. Bolli Bradykinin-induced preconditioning in patients undergoing coronary angioplasty J. Am. Coll. Cardiol., September 1, 1999; 34(3): 639 - 650. [Abstract] [Full Text] [PDF]
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R. D Rakhit, R. J Edwards, and M. S Marber Nitric oxide, nitrates and ischaemic preconditioning Cardiovasc Res, August 15, 1999; 43(3): 621 - 627. [Full Text] [PDF]
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P. B. Anning, B. D. Prendergast, P. A. MacCarthy, A. M. Shah, D. C. Buss, and M. J. Lewis ATP is involved in myocardial and vascular effects of exogenous bradykinin in ejecting guinea pig heart Am J Physiol Heart Circ Physiol, August 1, 1999; 277(2): H818 - H825. [Abstract] [Full Text] [PDF]
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H.-S. V. Chen, S. C. Body, and S. K. Shernan Myocardial Preconditioning: Characteristics, Mechanisms, and Clinical Applications Seminars in Cardiothoracic and Vascular Anesthesia, July 1, 1999; 3(2): 85 - 97. [Abstract] [PDF]
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S. Shigematsu, S. Ishida, D. C. Gute, and R. J. Korthuis Bradykinin prevents postischemic leukocyte adhesion and emigration and attenuates microvascular barrier disruption Am J Physiol Heart Circ Physiol, July 1, 1999; 277(1): H161 - H171. [Abstract] [Full Text] [PDF]
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S. Takeo and Y. Nasa Role of energy metabolism in the preconditioned heart - a possible contribution of mitochondria Cardiovasc Res, July 1, 1999; 43(1): 32 - 43. [Abstract] [Full Text] [PDF]
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P. Ping, J. Zhang, X. Cao, R. C. X. Li, D. Kong, X.-L. Tang, Y. Qiu, S. Manchikalapudi, J. A. Auchampach, R. G. Black, et al. PKC-dependent activation of p44/p42 MAPKs during myocardial ischemia-reperfusion in conscious rabbits Am J Physiol Heart Circ Physiol, May 1, 1999; 276(5): H1468 - H1481. [Abstract] [Full Text] [PDF]
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C. P. Baines, G. S. Liu, M. Birincioglu, S. D. Critz, M. V. Cohen, and J. M. Downey Ischemic preconditioning depends on interaction between mitochondrial KATP channels and actin cytoskeleton Am J Physiol Heart Circ Physiol, April 1, 1999; 276(4): H1361 - H1368. [Abstract] [Full Text] [PDF]
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P. Ping, H. Takano, J. Zhang, X.-L. Tang, Y. Qiu, R. C. X. Li, S. Banerjee, B. Dawn, Z. Balafonova, and R. Bolli Isoform-Selective Activation of Protein Kinase C by Nitric Oxide in the Heart of Conscious Rabbits : A Signaling Mechanism for Both Nitric Oxide–Induced and Ischemia-Induced Preconditioning Circ. Res., March 19, 1999; 84(5): 587 - 604. [Abstract] [Full Text] [PDF]
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S. Hoshida, N. Yamashita, K. Kawahara, T. Kuzuya, and M. Hori Amelioration by Quinapril of Myocardial Infarction Induced by Coronary Occlusion/Reperfusion in a Rabbit Model of Atherosclerosis : Possible Mechanisms Circulation, January 26, 1999; 99(3): 434 - 440. [Abstract] [Full Text] [PDF]
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T. Haruna, M. Horie, I. Kouchi, R. Nawada, K. Tsuchiya, M. Akao, H. Otani, T. Murakami, and S. Sasayama Coordinate Interaction Between ATP-Sensitive K+ Channel and Na+,K+-ATPase Modulates Ischemic Preconditioning Circulation, December 22, 1998; 98(25): 2905 - 2910. [Abstract] [Full Text] [PDF]
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T. Miki, T. Miura, R. Bunger, K. Suzuki, J. Sakamoto, and K. Shimamoto Ecto-5'-nucleotidase is not required for ischemic preconditioning in rabbit myocardium in situ Am J Physiol Heart Circ Physiol, October 1, 1998; 275(4): H1329 - H1337. [Abstract] [Full Text] [PDF]
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R. Schulz, H. Post, C. Vahlhaus, and G. Heusch Ischemic Preconditioning in Pigs: A Graded Phenomenon : Its Relation to Adenosine and Bradykinin Circulation, September 8, 1998; 98(10): 1022 - 1029. [Abstract] [Full Text] [PDF]
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C. Weinbrenner, G. S Liu, J. M Downey, and M. V Cohen Cyclosporine A limits myocardial infarct size even when administered after onset of ischemia Cardiovasc Res, June 1, 1998; 38(3): 676 - 684. [Abstract] [Full Text] [PDF]
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R. A. Kloner, R. Bolli, E. Marban, L. Reinlib, and E. Braunwald Medical and Cellular Implications of Stunning, Hibernation, and Preconditioning : An NHLBI Workshop Circulation, May 19, 1998; 97(18): 1848 - 1867. [Full Text] [PDF]
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 D. R. Meldrum Tumor necrosis factor in the heart Am J Physiol Regulatory Integrative Comp Physiol, March 1, 1998; 274(3): R577 - R595. [Abstract] [Full Text] [PDF]
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T. Miura, T. Miura, S. Kawamura, M. Goto, J. Sakamoto, A. Tsuchida, M. Matsuzaki, and K. Shimamoto Effect of protein kinase C inhibitors on cardioprotection by ischemic preconditioning depends on the number of preconditioning episodes Cardiovasc Res, March 1, 1998; 37(3): 700 - 709. [Abstract] [Full Text] [PDF]
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L. R.C Dekker Toward the heart of ischemic preconditioning Cardiovasc Res, January 1, 1998; 37(1): 14 - 20. [Full Text] [PDF]
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D. M Yellon, G. F Baxter, D. Garcia-Dorado, G. Heusch, and M. S Sumeray Ischaemic preconditioning: present position and future directions Cardiovasc Res, January 1, 1998; 37(1): 21 - 33. [Abstract] [Full Text] [PDF]
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J. Starkopf, T. V Andreasen, E. Bugge, and K. Ytrehus Lipid peroxidation, arachidonic acid and products of the lipoxygenase pathway in ischaemic preconditioning of rat heart Cardiovasc Res, January 1, 1998; 37(1): 66 - 75. [Abstract] [Full Text] [PDF]
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Y. Qiu, A. Rizvi, X.-L. Tang, S. Manchikalapudi, H. Takano, A. K. Jadoon, W.-J. Wu, and R. Bolli Nitric oxide triggers late preconditioning against myocardial infarction in conscious rabbits Am J Physiol Heart Circ Physiol, December 1, 1997; 273(6): H2931 - H2936. [Abstract] [Full Text] [PDF]
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F. Tomai, F. Crea, A. Gaspardone, F. Versaci, A. S. Ghini, R. De Paulis, L. Chiariello, and P. A. Gioffre Phentolamine Prevents Adaptation to Ischemia During Coronary Angioplasty : Role of {alpha}-Adrenergic Receptors in Ischemic Preconditioning Circulation, October 7, 1997; 96(7): 2171 - 2177. [Abstract] [Full Text]
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P. Ping, J. Zhang, Y. Qiu, X.-L. Tang, S. Manchikalapudi, X. Cao, and R. Bolli Ischemic Preconditioning Induces Selective Translocation of Protein Kinase C Isoforms {epsilon} and {eta} in the Heart of Conscious Rabbits Without Subcellular Redistribution of Total Protein Kinase C Activity Circ. Res., September 19, 1997; 81(3): 404 - 414. [Abstract] [Full Text]
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