© 1995 American Heart Association, Inc.
Articles |
Angiotensin II Partly Mediates Mechanical Stress–Induced Cardiac Hypertrophy
From the Third Department of Internal Medicine, University of Tokyo School of Medicine, Tokyo, Japan.
Correspondence to Issei Komuro, The Third Department of Medicine, University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan. E-mail komuro-tky@umin.u-tokyo.ac.jp.
Abstract We have previously shown that mechanical stress induces activation of protein kinases and increases in specific gene expression and protein synthesis in cardiac myocytes, all of which are similar to those evoked by humoral factors such as growth factors and hormones. Many lines of evidence have suggested that angiotensin II (Ang II) plays a vital role in cardiac hypertrophy, and it has been reported that secretion of Ang II from cultured cardiac myocytes was induced by mechanical stretch. To examine the role of Ang II in mechanical stress–induced cardiac hypertrophy, we stretched neonatal rat cardiac myocytes in the absence or presence of the Ang II receptor antagonists saralasin (an antagonist of both type 1 and type 2 receptors), CV-11974 (a type 1 receptor–specific antagonist), and PD123319 (a type 2 receptor–specific antagonist). Stretching cardiac myocytes by 20% using deformable silicone dishes rapidly increased the activities of mitogen-activated protein (MAP) kinase kinase activators and MAP kinases. Both saralasin and CV-11974 partially inhibited the stretch-induced increases in the activities of both kinases, whereas PD123319 showed no inhibitory effects. Stretching cardiac myocytes increased amino acid incorporation, which was also inhibited by approximately 70% with the pretreatment by saralasin or CV-11974. When the culture medium conditioned by stretching cardiocytes was transferred to nonstretched cardiac myocytes, the increase in MAP kinase activity was observed, and this increase was completely suppressed by saralasin or CV-11974. These results suggest that Ang II plays an important role in mechanical stress–induced cardiac hypertrophy and that there are also other (possibly nonsecretory) factors to induce hypertrophic responses.
Key Words: CV-11974 • signal transduction • MAP kinase • saralasin
This article has been cited by other articles:
 |
|
 |
|
  Kaiqiang Ji, M. Minakawa, K. Fukui, Y. Suzuki, and I. Fukuda Olmesartan improves left ventricular function in pressure-overload hypertrophied rat heart by blocking angiotensin II receptor with synergic effects of upregulation of angiotensin converting enzyme 2 Therapeutic Advances in Cardiovascular Disease, April 1, 2009; 3(2): 103 - 111. [Abstract] [PDF]
|
|
|
|
 |
|
 B. Pitt, A. Ahmed, T. E. Love, H. Krum, J. Nicolau, J. S. Cardoso, A. Parkhomenko, M. Aschermann, R. Corbalan, H. Solomon, et al. History of Hypertension and Eplerenone in Patients With Acute Myocardial Infarction Complicated by Heart Failure Hypertension, August 1, 2008; 52(2): 271 - 278. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X.-J. Zou, L. Yang, and S.-L. Yao Propofol Depresses Angiotensin II-Induced Cardiomyocyte Hypertrophy In Vitro Experimental Biology and Medicine, February 1, 2008; 233(2): 200 - 208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Frank, C. Kuhn, B. Brors, C. Hanselmann, M. Ludde, H. A. Katus, and N. Frey Gene Expression Pattern in Biomechanically Stretched Cardiomyocytes: Evidence for a Stretch-Specific Gene Program Hypertension, February 1, 2008; 51(2): 309 - 318. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. E. Cingolani and I. L. Ennis Sodium-Hydrogen Exchanger, Cardiac Overload, and Myocardial Hypertrophy Circulation, March 6, 2007; 115(9): 1090 - 1100. [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. Godeny and P. P. Sayeski ANG II-induced cell proliferation is dually mediated by c-Src/Yes/Fyn-regulated ERK1/2 activation in the cytoplasm and PKC{zeta}-controlled ERK1/2 activity within the nucleus Am J Physiol Cell Physiol, December 1, 2006; 291(6): C1297 - C1307. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Mozaffari, C. Patel, and S. W. Schaffer Mechanisms Underlying Afterload-Induced Exacerbation of Myocardial Infarct Size: Role of T-Type Ca2+ Channel Hypertension, May 1, 2006; 47(5): 912 - 919. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yamamoto, M. Ohishi, T. Katsuya, N. Ito, M. Ikushima, M. Kaibe, Y. Tatara, A. Shiota, S. Sugano, S. Takeda, et al. Deletion of Angiotensin-Converting Enzyme 2 Accelerates Pressure Overload-Induced Cardiac Dysfunction by Increasing Local Angiotensin II Hypertension, April 1, 2006; 47(4): 718 - 726. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Sekiguchi, X. Li, M. Coker, M. Flesch, P. M Barger, N. Sivasubramanian, and D. L Mann Cross-regulation between the renin-angiotensin system and inflammatory mediators in cardiac hypertrophy and failure Cardiovasc Res, August 15, 2004; 63(3): 433 - 442. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. N. Sabbah The cardiac support device and the Myosplint: treating heart failure by targeting left ventricular size and shape Ann. Thorac. Surg., June 1, 2003; 75(90060): S13 - 19. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. E Cingolani, N. G Perez, B. Pieske, D. von Lewinski, and M. C Camilion de Hurtado Stretch-elicited Na+/H+ exchanger activation: the autocrine/paracrine loop and its mechanical counterpart Cardiovasc Res, March 15, 2003; 57(4): 953 - 960. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Manabe, T. Shindo, and R. Nagai Gene Expression in Fibroblasts and Fibrosis: Involvement in Cardiac Hypertrophy Circ. Res., December 13, 2002; 91(12): 1103 - 1113. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Nemoto, M. Hamawaki, G. De Freitas, and B. A. Carabello differential effects of the angiotensin-converting enzyme inhibitor lisinopril versus the beta-adrenergic receptor blocker atenolol on hemodynamics and left ventricular contractile function in experimental mitral regurgitation J. Am. Coll. Cardiol., July 3, 2002; 40(1): 149 - 154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Yang, C. M. Bove, B. A. French, F. H. Epstein, S. S. Berr, J. M. DiMaria, J. J. Gibson, R. M. Carey, and C. M. Kramer Angiotensin II Type 2 Receptor Overexpression Preserves Left Ventricular Function After Myocardial Infarction Circulation, July 2, 2002; 106(1): 106 - 111. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Sakamoto and L. J. Goodyear Exercise Effects on Muscle Insulin Signaling and Action: Invited Review: Intracellular signaling in contracting skeletal muscle J Appl Physiol, July 1, 2002; 93(1): 369 - 383. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sotoudeh, Y.-S. Li, N. Yajima, C.-C. Chang, T.-C. Tsou, Y. Wang, S. Usami, A. Ratcliffe, S. Chien, and J. Y.-J. Shyy Induction of apoptosis in vascular smooth muscle cells by mechanical stretch Am J Physiol Heart Circ Physiol, May 1, 2002; 282(5): H1709 - H1716. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Apodaca Modulation of membrane traffic by mechanical stimuli Am J Physiol Renal Physiol, February 1, 2002; 282(2): F179 - F190. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Aikawa, T. Nagai, S. Kudoh, Y. Zou, M. Tanaka, M. Tamura, H. Akazawa, H. Takano, R. Nagai, and I. Komuro Integrins Play a Critical Role in Mechanical Stress-Induced p38 MAPK Activation Hypertension, February 1, 2002; 39(2): 233 - 238. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Iemitsu, T. Miyauchi, S. Maeda, S. Sakai, T. Kobayashi, N. Fujii, H. Miyazaki, M. Matsuda, and I. Yamaguchi Physiological and pathological cardiac hypertrophy induce different molecular phenotypes in the rat Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2001; 281(6): R2029 - R2036. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Fielitz, S. Hein, V. Mitrovic, R. Pregla, H. R. Zurbrugg, C. Warnecke, J. Schaper, E. Fleck, and V. Regitz-Zagrosek Activation of the cardiac renin-angiotensin system and increased myocardial collagen expression in human aortic valve disease J. Am. Coll. Cardiol., April 1, 2001; 37(5): 1443 - 1449. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Lebeche, Zhao Bin Kang, and R. Hajjar Candesartan abrogates G protein-coupled receptors agonist-induced MAPK activation and cardiac myocyte hypertrophy Journal of Renin-Angiotensin-Aldosterone System, March 1, 2001; 2(1_suppl): S154 - S161. [Abstract] [PDF]
|
|
|
|
|
|
T. Morgan Review: Effect of combining angiotensin receptor blockers and ACE inhibitors on cardiovascular disease Journal of Renin-Angiotensin-Aldosterone System, March 1, 2001; 2(1_suppl): S223 - S226. [PDF]
|
|
|
|
|
|
Y. Sakata, T. Masuyama, K. Yamamoto, R. Doi, T. Mano, T. Kuzuya, T. Miwa, H. Takeda, and M. Hori Renin angiotensin system-dependent hypertrophy as a contributor to heart failure in hypertensive rats: different characteristics from renin angiotensin system-independent hypertrophy J. Am. Coll. Cardiol., January 1, 2001; 37(1): 293 - 299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Leopold and J. Loscalzo Cyclic strain modulates resistance to oxidant stress by increasing G6PDH expression in smooth muscle cells Am J Physiol Heart Circ Physiol, November 1, 2000; 279(5): H2477 - H2485. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Izumi, S. Kim, Y. Zhan, M. Namba, H. Yasumoto, and H. Iwao Important Role of Angiotensin II-Mediated c-Jun NH2-Terminal Kinase Activation in Cardiac Hypertrophy in Hypertensive Rats Hypertension, October 1, 2000; 36(4): 511 - 516. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yamamoto, T. Masuyama, Y. Sakata, T. Mano, N. Nishikawa, H. Kondo, N. Akehi, T. Kuzuya, T. Miwa, and M. Hori Roles of renin-angiotensin and endothelin systems in development of diastolic heart failure in hypertensive hearts Cardiovasc Res, August 1, 2000; 47(2): 274 - 283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ruwhof and A. van der Laarse Mechanical stress-induced cardiac hypertrophy: mechanisms and signal transduction pathways Cardiovasc Res, July 1, 2000; 47(1): 23 - 37. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. St. J. Sutton and N. Sharpe Left Ventricular Remodeling After Myocardial Infarction : Pathophysiology and Therapy Circulation, June 27, 2000; 101(25): 2981 - 2988. [Full Text] [PDF]
|
|
|
|
|
|
J. Fukuzawa, G. W. Booz, R. A. Hunt, N. Shimizu, V. Karoor, K. M. Baker, and D. E. Dostal Cardiotrophin-1 Increases Angiotensinogen mRNA in Rat Cardiac Myocytes Through STAT3 : An Autocrine Loop for Hypertrophy Hypertension, June 1, 2000; 35(6): 1191 - 1196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Tsuruda, J. Kato, K. Kitamura, T. Imamura, Y. Koiwaya, K. Kangawa, I. Komuro, Y. Yazaki, and T. Eto Enhanced Adrenomedullin Production by Mechanical Stretching in Cultured Rat Cardiomyocytes Hypertension, June 1, 2000; 35(6): 1210 - 1214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yamamoto, T. Masuyama, Y. Sakata, R. Doi, K. Ono, T. Mano, H. Kondo, T. Kuzuya, T. Miwa, and M. Hori Local neurohumoral regulation in the transition to isolated diastolic heart failure in hypertensive heart disease: absence of AT1 receptor downregulation and 'overdrive' of the endothelin system Cardiovasc Res, June 1, 2000; 46(3): 421 - 432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Ricardo, D. F. Franzoni, C. D. Roesener, J. M. Crisman, and J. R. Diamond Angiotensinogen and AT1 antisense inhibition of osteopontin translation in rat proximal tubular cells Am J Physiol Renal Physiol, May 1, 2000; 278(5): F708 - F716. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. G Stanley, H. Patel, A. L Knight, and B. Williams Mechanical strain-induced human vascular matrix synthesis: The role of angiotensin II Journal of Renin-Angiotensin-Aldosterone System, March 1, 2000; 1(1): 32 - 35. [Abstract] [PDF]
|
|
|
|
 |
|
 C. Li, Y. Hu, G. Sturm, G. Wick, and Q. Xu Ras/Rac-Dependent Activation of p38 Mitogen-Activated Protein Kinases in Smooth Muscle Cells Stimulated by Cyclic Strain Stress Arterioscler. Thromb. Vasc. Biol., March 1, 2000; 20 (3): e1 - e9. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Higaki, M. Aoki, R. Morishita, I. Kida, Y. Taniyama, N. Tomita, K. Yamamoto, A. Moriguchi, Y. Kaneda, and T. Ogihara In Vivo Evidence of the Importance of Cardiac Angiotensin-Converting Enzyme in the Pathogenesis of Cardiac Hypertrophy Arterioscler. Thromb. Vasc. Biol., February 1, 2000; 20(2): 428 - 434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Q. Liu Focal Expression of Angiotensin II Type 1 Receptor and Smooth Muscle Cell Proliferation in the Neointima of Experimental Vein Grafts : Relation to Eddy Blood Flow Arterioscler. Thromb. Vasc. Biol., November 1, 1999; 19(11): 2630 - 2639. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Kentish A Role for the Sarcolemmal Na+/H+ Exchanger in the Slow Force Response to Myocardial Stretch Circ. Res., October 15, 1999; 85(8): 658 - 660. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Liu, A. K. Tanswell, and M. Post Mechanical force-induced signal transduction in lung cells Am J Physiol Lung Cell Mol Physiol, October 1, 1999; 277(4): L667 - L683. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Matrougui, L. Loufrani, C. Heymes, B. I. Levy, and D. Henrion Activation of AT2 Receptors by Endogenous Angiotensin II Is Involved in Flow-Induced Dilation in Rat Resistance Arteries Hypertension, October 1, 1999; 34(4): 659 - 665. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Li, Y. Hu, M. Mayr, and Q. Xu Cyclic Strain Stress-induced Mitogen-activated Protein Kinase (MAPK) Phosphatase 1 Expression in Vascular Smooth Muscle Cells Is Regulated by Ras/Rac-MAPK Pathways J. Biol. Chem., September 3, 1999; 274(36): 25273 - 25280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. C Wollert and H. Drexler The renin-angiotensin system and experimental heart failure Cardiovasc Res, September 1, 1999; 43(4): 838 - 849. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Park, R. M. Adam, C. A. Peters, P. D. Guthrie, Z. Sun, M. Klagsbrun, and M. R. Freeman AP-1 mediates stretch-induced expression of HB-EGF in bladder smooth muscle cells Am J Physiol Cell Physiol, August 1, 1999; 277(2): C294 - C301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Malhotra, J. Sadoshima, F. C. Brosius III, and S. Izumo Mechanical Stretch and Angiotensin II Differentially Upregulate the Renin-Angiotensin System in Cardiac Myocytes In Vitro Circ. Res., July 23, 1999; 85(2): 137 - 146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. Nicholas and K. D. Philipson Cardiac expression of the Na+/Ca2+ exchanger NCX1 is GATA factor dependent Am J Physiol Heart Circ Physiol, July 1, 1999; 277(1): H324 - H330. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ogino, B. Cai, A. Gu, T. Kohmoto, N. Yamamoto, and D. Burkhoff Factors contributing to pressure overload-induced immediate early gene expression in adult rat hearts in vivo Am J Physiol Heart Circ Physiol, July 1, 1999; 277(1): H380 - H387. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-D. Chen, Y.-S. Li, M. Kim, S. Li, S. Yuan, S. Chien, and J. Y-J. Shyy Mechanotransduction in Response to Shear Stress. ROLES OF RECEPTOR TYROSINE KINASES, INTEGRINS, AND Shc J. Biol. Chem., June 25, 1999; 274(26): 18393 - 18400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sasayama, A. Matsumori, and Y. Kihara New insights into the pathophysiological role for cytokines in heart failure Cardiovasc Res, June 1, 1999; 42(3): 557 - 564. [Full Text] [PDF]
|
|
|
|
 |
|
 G. GRUDEN, S. THOMAS, D. BURT, W. ZHOU, G. CHUSNEY, L. GNUDI, and G. VIBERTI Interaction of Angiotensin II and Mechanical Stretch on Vascular Endothelial Growth Factor Production by Human Mesangial Cells J. Am. Soc. Nephrol., April 1, 1999; 10(4): 730 - 737. [Abstract] [Full Text]
|
|
|
|
|
|
J. E. Bishop and G. Lindahl Regulation of cardiovascular collagen synthesis by mechanical load Cardiovasc Res, April 1, 1999; 42(1): 27 - 44. [Full Text] [PDF]
|
|
|
|
|
|
R. Aikawa, I. Komuro, T. Yamazaki, Y. Zou, S. Kudoh, W. Zhu, T. Kadowaki, and Y. Yazaki Rho Family Small G Proteins Play Critical Roles in Mechanical Stress–Induced Hypertrophic Responses in Cardiac Myocytes Circ. Res., March 5, 1999; 84(4): 458 - 466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Koide, B. A. Carabello, C. C. Conrad, J. M. Buckley, G. DeFreyte, M. Barnes, R. J. Tomanek, C.-C. Wei, L. J. Dell'Italia, G. Cooper IV, et al. Hypertrophic response to hemodynamic overload: role of load vs. renin-angiotensin system activation Am J Physiol Heart Circ Physiol, February 1, 1999; 276(2): H350 - H358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Park, J. G. Borer, M. R. Freeman, and C. A. Peters Stretch activates heparin-binding EGF-like growth factor expression in bladder smooth muscle cells Am J Physiol Cell Physiol, November 1, 1998; 275(5): C1247 - C1254. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. E. Cingolani, B. V. Alvarez, I. L. Ennis, and M. C. Camilion de Hurtado Stretch-Induced Alkalinization of Feline Papillary Muscle : An Autocrine-Paracrine System Circ. Res., October 19, 1998; 83(8): 775 - 780. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Yano, S. Kim, Y. Izumi, S. Yamanaka, and H. Iwao Differential Activation of Cardiac c-Jun Amino-Terminal Kinase and Extracellular Signal-Regulated Kinase in Angiotensin II–Mediated Hypertension Circ. Res., October 5, 1998; 83(7): 752 - 760. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kudoh, I. Komuro, Y. Hiroi, Y. Zou, K. Harada, T. Sugaya, N. Takekoshi, K. Murakami, T. Kadowaki, and Y. Yazaki Mechanical Stretch Induces Hypertrophic Responses in Cardiac Myocytes of Angiotensin II Type 1a Receptor Knockout Mice J. Biol. Chem., September 11, 1998; 273(37): 24037 - 24043. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Tamura, S. Umemura, N. Nyui, K. Hibi, T. Ishigami, M. Kihara, Y. Toya, and M. Ishii Activation of angiotensinogen gene in cardiac myocytes by angiotensin II and mechanical stretch Am J Physiol Regulatory Integrative Comp Physiol, July 1, 1998; 275(1): R1 - R9. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Ross, C. Pham, S.-Y. Shai, J. I. Goldhaber, C. Fenczik, C. C. Glembotski, M. H. Ginsberg, and J. C. Loftus ß1 Integrins Participate in the Hypertrophic Response of Rat Ventricular Myocytes Circ. Res., June 15, 1998; 82(11): 1160 - 1172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Liang and D. G. Gardner Autocrine/Paracrine Determinants of Strain-activated Brain Natriuretic Peptide Gene Expression in Cultured Cardiac Myocytes J. Biol. Chem., June 5, 1998; 273(23): 14612 - 14619. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Harada, I. Komuro, I. Shiojima, D. Hayashi, S. Kudoh, T. Mizuno, K. Kijima, H. Matsubara, T. Sugaya, K. Murakami, et al. Pressure Overload Induces Cardiac Hypertrophy in Angiotensin II Type 1A Receptor Knockout Mice Circulation, May 19, 1998; 97(19): 1952 - 1959. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Harada, I. Komuro, Y. Zou, S. Kudoh, K. Kijima, H. Matsubara, T. Sugaya, K. Murakami, and Y. Yazaki Acute Pressure Overload Could Induce Hypertrophic Responses in the Heart of Angiotensin II Type 1a Knockout Mice Circ. Res., April 20, 1998; 82(7): 779 - 785. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Aoki, S. Izumo, and J. Sadoshima Angiotensin II Activates RhoA in Cardiac Myocytes : A Critical Role of RhoA in Angiotensin II–Induced Premyofibril Formation Circ. Res., April 6, 1998; 82(6): 666 - 676. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. L. Ennis, B. V. Alvarez, M. C. C. de Hurtado, and H. E. Cingolani Enalapril Induces Regression of Cardiac Hypertrophy and Normalization of pHi Regulatory Mechanisms Hypertension, April 1, 1998; 31(4): 961 - 967. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yamazaki, I. Komuro, S. Kudoh, Y. Zou, R. Nagai, R. Aikawa, H. Uozumi, and Y. Yazaki Role of Ion Channels and Exchangers in Mechanical Stretch–Induced Cardiomyocyte Hypertrophy Circ. Res., March 9, 1998; 82(4): 430 - 437. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. C. de Hurtado, B. V. Alvarez, N. G. Perez, I. L. Ennis, and H. E. Cingolani Angiotensin II Activates Na+-Independent Cl--HCO3- Exchange in Ventricular Myocardium Circ. Res., March 9, 1998; 82(4): 473 - 481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hamawaki, T. M. Coffman, A. Lashus, M. Koide, M. R. Zile, M. I. Oliverio, G. Defreyte, G. Cooper IV, and B. A. Carabello Pressure-overload hypertrophy is unabated in mice devoid of AT1A receptors Am J Physiol Heart Circ Physiol, March 1, 1998; 274(3): H868 - H873. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zou, I. Komuro, T. Yamazaki, S. Kudoh, R. Aikawa, W. Zhu, I. Shiojima, Y. Hiroi, K. Tobe, T. Kadowaki, et al. Cell Type–Specific Angiotensin II–Evoked Signal Transduction Pathways : Critical Roles of Gß{gamma} Subunit, Src Family, and Ras in Cardiac Fibroblasts Circ. Res., February 23, 1998; 82(3): 337 - 345. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ogawa, B. G. Bruneau, N. Yokota, M. L. Kuroski de Bold, and A. J. de Bold Tissue-Specific Regulation of Renal and Cardiac Atrial Natriuretic Factor Gene Expression in Deoxycorticosterone Acetate–Salt Rats Hypertension, December 1, 1997; 30(6): 1342 - 1347. [Abstract] [Full Text]
|
|
|
|
|
|
J. Magga, O. Vuolteenaho, M. Marttila, and H. Ruskoaho Endothelin-1 Is Involved in Stretch-Induced Early Activation of B-Type Natriuretic Peptide Gene Expression in Atrial but Not in Ventricular Myocytes : Acute Effects of Mixed ETA/ETB and AT1 Receptor Antagonists In Vivo and In Vitro Circulation, November 4, 1997; 96(9): 3053 - 3062. [Abstract] [Full Text]
|
|
|
|
 |
|
 T. C. Herzig, S. M. Jobe, H. Aoki, J. D. Molkentin, A. W. Cowley Jr., S. Izumo, and B. E. Markham Angiotensin II type1a receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overload PNAS, July 8, 1997; 94(14): 7543 - 7548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yamazaki, I. Komuro, Y. Zou, S. Kudoh, I. Shiojima, Y. Hiroi, T. Mizuno, R. Aikawa, H. Takano, and Y. Yazaki Norepinephrine Induces the raf-1 Kinase/Mitogen-Activated Protein Kinase Cascade Through Both {alpha}1- and ß-Adrenoceptors Circulation, March 4, 1997; 95(5): 1260 - 1268. [Abstract] [Full Text]
|
|
|
|
|
|
S. Kudoh, I. Komuro, T. Mizuno, T. Yamazaki, Y. Zou, I. Shiojima, N. Takekoshi, and Y. Yazaki Angiotensin II Stimulates c-Jun NH2-Terminal Kinase in Cultured Cardiac Myocytes of Neonatal Rats Circ. Res., January 1, 1997; 80(1): 139 - 146. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Zou, I. Komuro, T. Yamazaki, R. Aikawa, S. Kudoh, I. Shiojima, Y. Hiroi, T. Mizuno, and Y. Yazaki Protein Kinase C, but Not Tyrosine Kinases or Ras, Plays a Critical Role in Angiotensin II-induced Activation of Raf-1 Kinase and Extracellular Signal-regulated Protein Kinases in Cardiac Myocytes J. Biol. Chem., December 27, 1996; 271(52): 33592 - 33597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kijima, H. Matsubara, S. Murasawa, K. Maruyama, Y. Mori, N. Ohkubo, I. Komuro, Y. Yazaki, T. Iwasaka, and M. Inada Mechanical Stretch Induces Enhanced Expression of Angiotensin II Receptor Subtypes in Neonatal Rat Cardiac Myocytes Circ. Res., October 1, 1996; 79(4): 887 - 897. [Abstract] [Full Text]
|
|
|
|
|
|
T. Yamazaki, I. Komuro, S. Kudoh, Y. Zou, I. Shiojima, Y. Hiroi, T. Mizuno, K. Maemura, H. Kurihara, R. Aikawa, et al. Endothelin-1 Is Involved in Mechanical Stress-induced Cardiomyocyte Hypertrophy J. Biol. Chem., February 9, 1996; 271(6): 3221 - 3228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Liang, A. Atakilit, and D. G. Gardner Integrin Dependence of Brain Natriuretic Peptide Gene Promoter Activation by Mechanical Strain J. Biol. Chem., June 30, 2000; 275(27): 20355 - 20360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sano, K. Fukuda, H. Kodama, J. Pan, M. Saito, J. Matsuzaki, T. Takahashi, S. Makino, T. Kato, and S. Ogawa Interleukin-6 Family of Cytokines Mediate Angiotensin II-induced Cardiac Hypertrophy in Rodent Cardiomyocytes J. Biol. Chem., September 15, 2000; 275(38): 29717 - 29723. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Tamura, Y. E. Chen, M. Lopez-Ilasaca, L. Daviet, N. Tamura, T. Ishigami, M. Akishita, I. Takasaki, Y. Tokita, R. E. Pratt, et al. Molecular Mechanism of Fibronectin Gene Activation by Cyclic Stretch in Vascular Smooth Muscle Cells J. Biol. Chem., October 27, 2000; 275(44): 34619 - 34627. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Uozumi, Y. Hiroi, Y. Zou, E. Takimoto, H. Toko, P. Niu, M. Shimoyama, Y. Yazaki, R. Nagai, and I. Komuro gp130 Plays a Critical Role in Pressure Overload-induced Cardiac Hypertrophy J. Biol. Chem., June 15, 2001; 276(25): 23115 - 23119. [Abstract] [Full Text] [PDF]
|
|