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Circulation Research. 1994;75:650-658

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Circulation Research, Vol 75, 650-658, Copyright © 1994 by American Heart Association

ARTICLES

Extracellular matrix remodeling after balloon angioplasty injury in a rabbit model of restenosis

BH Strauss, RJ Chisholm, FW Keeley, AI Gotlieb, RA Logan and PW Armstrong
Division of Cardiology, St Michael's Hospital, Toronto, Ontario, Canada.

Remodeling of the vessel wall after balloon angioplasty injury is incompletely understood, and in particular, the role of extracellular matrix synthesis in restenosis has received little attention. The objective of the present study was to determine the sequence of changes in collagen, elastin, and proteoglycan synthesis and content after balloon injury and to relate these changes to growth of the intimal lesions and extent of cell proliferation. In a double-injury non- cholesterol-fed model, right iliac arterial lesions in 43 rabbits were treated with balloon angioplasty, and the rabbits were killed at five time points ranging from immediate to 12 weeks. Vessel wall collagen and elastin content and synthesis were measured after incubation with 14C-proline and separation with a cyanogen bromide extraction procedure. Sulfated glycosaminoglycan synthesis was measured after incubation with [35S]sulfate, papain digestion, and ethanol precipitation. Continuous in vivo infusion of bromodeoxyuridine (96 hours) was used to assess cell proliferation. The intimal area significantly increased from 0.27 +/- 0.08 to 0.73 +/- 0.11 mm2 between 0 and 12 weeks. Intimal and medial cell proliferation were modest and peaked at 1 week (labeling indexes of 4.8% and 3.0%, respectively) and then markedly declined by 2 weeks. Significant increases in collagen, elastin, and proteoglycan synthesis, up to 4 to 10 times above control nondamaged contralateral iliac arteries, were noted at 1, 2, and 4 weeks. These increases in synthesis were accompanied by significant increases in collagen and elastin content (by approximately 35%) that coincided with the temporal increase in cross-sectional area.(ABSTRACT TRUNCATED AT 250 WORDS)


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J. Rodes, G. Cote, J. Lesperance, M. G. Bourassa, S. Doucet, L. Bilodeau, O. F. Bertrand, F. Harel, R. Gallo, and J.-C. Tardif
Prevention of Restenosis After Angioplasty in Small Coronary Arteries With Probucol
Circulation, February 10, 1998; 97(5): 429 - 436.
[Abstract] [Full Text] [PDF]

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M. Yamamoto, M. Aoyagi, S. Tajima, H. Wachi, N. Fukai, Y. Matsushima, and K. Yamamoto
Increase in Elastin Gene Expression and Protein Synthesis in Arterial Smooth Muscle Cells Derived From Patients with Moyamoya Disease
Stroke, September 1, 1997; 28(9): 1733 - 1738.
[Abstract] [Full Text]

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J.-C. Tardif, G. Cote, J. Lesperance, M. Bourassa, J. Lambert, S. Doucet, L. Bilodeau, S. Nattel, P. de Guise, and The Multivitamins and Probucol Study Group
Probucol and Multivitamins in the Prevention of Restenosis after Coronary Angioplasty
N. Engl. J. Med., August 7, 1997; 337(6): 365 - 372.
[Abstract] [Full Text] [PDF]

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W. D. Coats, P. Whittaker, D. T. Cheung, J. W. Currier, B. Han, and D. P. Faxon
Collagen Content Is Significantly Lower in Restenotic Versus Nonrestenotic Vessels After Balloon Angioplasty in the Atherosclerotic Rabbit Model
Circulation, March 4, 1997; 95(5): 1293 - 1300.
[Abstract] [Full Text]

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Y. Shi, J. E. O'Brien, L. Ala-Kokko, W. Chung, J. D. Mannion, and A. Zalewski
Origin of Extracellular Matrix Synthesis During Coronary Repair
Circulation, February 18, 1997; 95(4): 997 - 1006.
[Abstract] [Full Text]

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 Arterioscler. Thromb. Vasc. Bio.Home page
A. Nagler, H.-Q. Miao, H. Aingorn, M. Pines, O. Genina, and I. Vlodavsky
Inhibition of Collagen Synthesis, Smooth Muscle Cell Proliferation, and Injury-Induced Intimal Hyperplasia by Halofuginone
Arterioscler Thromb Vasc Biol, January 1, 1997; 17(1): 194 - 202.
[Abstract] [Full Text]

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J. A. Bittl
Advances in Coronary Angioplasty
N. Engl. J. Med., October 24, 1996; 335(17): 1290 - 1302.
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 Circ. Res.Home page
B. H. Strauss, R. Robinson, W. B. Batchelor, R. J. Chisholm, G. Ravi, M. K. Natarajan, R. A. Logan, S. R. Mehta, D. E. Levy, A. M. Ezrin, et al.
In Vivo Collagen Turnover Following Experimental Balloon Angioplasty Injury and the Role of Matrix Metalloproteinases
Circ. Res., September 1, 1996; 79(3): 541 - 550.
[Abstract] [Full Text]

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G. S. Mintz, J. J. Popma, A. D. Pichard, K. M. Kent, L. F. Satler, S. Chiu Wong, M. K. Hong, J. A. Kovach, and M. B. Leon
Arterial Remodeling After Coronary Angioplasty : A Serial Intravascular Ultrasound Study
Circulation, July 1, 1996; 94(1): 35 - 43.
[Abstract] [Full Text]

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D. J. Marhamati and G. E. Sonenshein
B-Myb Expression in Vascular Smooth Muscle Cells Occurs in a Cell Cycle-dependent Fashion and Down-regulates Promoter Activity of Type I Collagen Genes
J. Biol. Chem., February 16, 1996; 271(7): 3359 - 3365.
[Abstract] [Full Text] [PDF]

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M. Aoyagi, M. Yamamoto, H. Wakimoto, H. Azuma, K. Hirakawa, and K. Yamamoto
Immunohistochemical Detection of Ki-67 in Replicative Smooth Muscle Cells of Rabbit Carotid Arteries After Balloon Denudation
Stroke, December 1, 1995; 26(12): 2328 - 2332.
[Abstract] [Full Text]

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R. L. Wilensky, K. L. March, I. Gradus-Pizlo, G. Sandusky, N. Fineberg, and D. R. Hathaway
Vascular Injury, Repair, and Restenosis After Percutaneous Transluminal Angioplasty in the Atherosclerotic Rabbit
Circulation, November 15, 1995; 92(10): 2995 - 3005.
[Abstract] [Full Text]

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P. G. Steg, M. Ziol, O. Tahlil, C. Robert, P. Masson, D. Pruneau, P. Bruneval, and P. Belichard
Reduction of Intimal Hyperplasia by Naroparcil, a 4-Methylumbelliferyl ß-D-Xyloside Analogue, After Arterial Injury in the Hypercholesterolemic Rabbit
Circ. Res., November 1, 1995; 77(5): 919 - 926.
[Abstract] [Full Text]

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F. M. van Bockxmeer, C. D. S. Mamotte, F. A. Gibbons, V. Burke, and R. R. Taylor
Angiotensin-Converting Enzyme and Apolipoprotein E Genotypes and Restenosis After Coronary Angioplasty
Circulation, October 15, 1995; 92(8): 2066 - 2071.
[Abstract] [Full Text]


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