Circulation Research, Vol 75, 539-545, Copyright © 1994 by American Heart Association

ARTICLES

Smooth muscle cell migration and matrix metalloproteinase expression after arterial injury in the rat

MP Bendeck, N Zempo, AW Clowes, RE Galardy and MA Reidy
University of Washington, Department of Pathology, Seattle 98915.

We have characterized matrix metalloproteinase expression in the rat carotid artery after two forms of arterial injury, balloon catheter denudation and nylon filament denudation. Gelatinolytic enzymes with molecular masses of 70 and 62 kD were produced constitutively in the rat carotid. Production of an 88-kD gelatinase was induced after balloon catheter injury, and proteinase production continued during the period of migration of smooth muscle cells from the media to the intima, from 6 hours to 6 days after balloon catheter injury. In addition, a marked increase in 62-kD gelatinolytic activity was observed between 4 and 14 days after arterial injury. Gelatinase activities (88 and 62 kD) were also increased after nylon filament denudation but were markedly less after this injury than after balloon catheter injury. These results suggested a correlation between gelatinase activity and smooth muscle cell migration after arterial injury. Administration of a metalloproteinase inhibitor after balloon catheter injury resulted in a 97% reduction in the number of smooth muscle cells migrating into the intima. Therefore, we hypothesize that gelatinase expression directly facilitates smooth muscle cell migration within the media and into the intima. These results suggest that gelatinases are involved in the vascular smooth muscle cell activation and neointimal formation that characterize arterial tissue remodeling after injury.

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				M. B. DeYoung, C. Tom, and D. A. Dichek Plasminogen Activator Inhibitor Type 1 Increases Neointima Formation in Balloon-Injured Rat Carotid Arteries Circulation, October 16, 2001; 104(16): 1972 - 1971. [Abstract] [Full Text] [PDF]

				M. V. Gurjar, J. DeLeon, R. V. Sharma, and R. C. Bhalla Mechanism of inhibition of matrix metalloproteinase-9 induction by NO in vascular smooth muscle cells J Appl Physiol, September 1, 2001; 91(3): 1380 - 1386. [Abstract] [Full Text] [PDF]

				J. L. Johnson, G. J. J. M. van Eys, G. D. Angelini, and S. J. George Injury Induces Dedifferentiation of Smooth Muscle Cells and Increased Matrix-Degrading Metalloproteinase Activity in Human Saphenous Vein Arterioscler Thromb Vasc Biol, July 1, 2001; 21(7): 1146 - 1151. [Abstract] [Full Text] [PDF]

				L. J. Feldman, M. Mazighi, A. Scheuble, J.-F. Deux, E. De Benedetti, C. Badier-Commander, E. Brambilla, D. Henin, P. G. Steg, and M.-P. Jacob Differential Expression of Matrix Metalloproteinases After Stent Implantation and Balloon Angioplasty in the Hypercholesterolemic Rabbit Circulation, June 26, 2001; 103(25): 3117 - 3122. [Abstract] [Full Text] [PDF]

				M. Bond, A. J Chase, A. H Baker, and A. C Newby Inhibition of transcription factor NF-{kappa}B reduces matrix metalloproteinase-1, -3 and -9 production by vascular smooth muscle cells Cardiovasc Res, June 1, 2001; 50(3): 556 - 565. [Abstract] [Full Text] [PDF]

				F. J. Miller Jr Adventitial Fibroblasts : Backstage Journeymen Arterioscler Thromb Vasc Biol, May 1, 2001; 21(5): 722 - 723. [Full Text] [PDF]

				Y. Yamasaki, K. Miyoshi, N. Oda, M. Watanabe, H. Miyake, J. Chan, X. Wang, L. Sun, C. Tang, G. McMahon, et al. Weekly Dosing With the Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitor SU9518 Significantly Inhibits Arterial Stenosis Circ. Res., March 30, 2001; 88(6): 630 - 636. [Abstract] [Full Text] [PDF]

				R. Shibata, H. Kai, Y. Seki, S. Kato, M. Morimatsu, K. Kaibuchi, and T. Imaizumi Role of Rho-Associated Kinase in Neointima Formation After Vascular Injury Circulation, January 16, 2001; 103(2): 284 - 289. [Abstract] [Full Text] [PDF]

				D. Godin, E. Ivan, C. Johnson, R. Magid, and Z. S. Galis Remodeling of Carotid Artery Is Associated With Increased Expression of Matrix Metalloproteinases in Mouse Blood Flow Cessation Model Circulation, December 5, 2000; 102(23): 2861 - 2866. [Abstract] [Full Text] [PDF]

				A. Cho, J. Graves, and M. A. Reidy Mitogen-Activated Protein Kinases Mediate Matrix Metalloproteinase-9 Expression in Vascular Smooth Muscle Cells Arterioscler Thromb Vasc Biol, December 1, 2000; 20(12): 2527 - 2532. [Abstract] [Full Text] [PDF]

				A. Vieillard-Baron, E. Frisdal, S. Eddahibi, I. Deprez, A. H. Baker, A. C. Newby, P. Berger, M. Levame, B. Raffestin, S. Adnot, et al. Inhibition of Matrix Metalloproteinases by Lung TIMP-1 Gene Transfer or Doxycycline Aggravates Pulmonary Hypertension in Rats Circ. Res., September 1, 2000; 87(5): 418 - 425. [Abstract] [Full Text] [PDF]

				E. H. Ohlstein, A. M. Romanic, L. V. Clark, R. D. Kapadia, S. K. Sarkar, R. Gagnon, and S. Chandra Application of in vivo and ex vivo magnetic resonance imaging for evaluation of tranilast on neointima formation following balloon angioplasty of the rat carotid artery Cardiovasc Res, September 1, 2000; 47(4): 759 - 768. [Abstract] [Full Text] [PDF]

				K. Mavromatis, T. Fukai, M. Tate, N. Chesler, D. N. Ku, and Z. S. Galis Early Effects of Arterial Hemodynamic Conditions on Human Saphenous Veins Perfused Ex Vivo Arterioscler Thromb Vasc Biol, August 1, 2000; 20(8): 1889 - 1895. [Abstract] [Full Text] [PDF]

				R. Palumbo, C. Gaetano, G. Melillo, E. Toschi, A. Remuzzi, and M. C. Capogrossi Shear Stress Downregulation of Platelet-Derived Growth Factor Receptor-{beta} and Matrix Metalloprotease-2 Is Associated With Inhibition of Smooth Muscle Cell Invasion and Migration Circulation, July 11, 2000; 102(2): 225 - 230. [Abstract] [Full Text] [PDF]

				B. J. G. L. de Smet, D. de Kleijn, R. Hanemaaijer, J. H. Verheijen, L. Robertus, Y. J. M. van der Helm, C. Borst, and M. J. Post Metalloproteinase Inhibition Reduces Constrictive Arterial Remodeling After Balloon Angioplasty : A Study in the Atherosclerotic Yucatan Micropig Circulation, June 27, 2000; 101(25): 2962 - 2967. [Abstract] [Full Text] [PDF]

				M. P. Bendeck, C. Irvin, M. Reidy, L. Smith, D. Mulholland, M. Horton, and C. M. Giachelli Smooth Muscle Cell Matrix Metalloproteinase Production Is Stimulated via {alpha}v{beta}3 Integrin Arterioscler Thromb Vasc Biol, June 1, 2000; 20(6): 1467 - 1472. [Abstract] [Full Text] [PDF]

				H. R. Lijnen, B. Van Hoef, M. Dewerchin, and D. Collen {alpha}2-Antiplasmin Gene Deficiency in Mice Does Not Affect Neointima Formation After Vascular Injury Arterioscler Thromb Vasc Biol, June 1, 2000; 20(6): 1488 - 1492. [Abstract] [Full Text] [PDF]

				P.-Y. Cheung, G. Sawicki, M. Wozniak, W. Wang, M. W. Radomski, and R. Schulz Matrix Metalloproteinase-2 Contributes to Ischemia-Reperfusion Injury in the Heart Circulation, April 18, 2000; 101(15): 1833 - 1839. [Abstract] [Full Text] [PDF]

				S. Kanda, M. Kuzuya, M. A. Ramos, T. Koike, K. Yoshino, S. Ikeda, and A. Iguchi Matrix Metalloproteinase and {alpha}v{beta}3 Integrin-Dependent Vascular Smooth Muscle Cell Invasion Through a Type I Collagen Lattice Arterioscler Thromb Vasc Biol, April 1, 2000; 20(4): 998 - 1005. [Abstract] [Full Text] [PDF]