Circulation Research, Vol 75, 252-260, Copyright © 1994 by American Heart Association

ARTICLES

Quantitative analysis of potassium channel mRNA expression in atrial and ventricular muscle of rats

JE Dixon and D McKinnon
Department of Neurobiology and Behavior, State University of New York at Stony Brook 11794-5230.

The expression of 15 different potassium channel genes in rat atrial and ventricular muscle was quantitatively compared by use of an RNase protection assay. Of these genes, only five, Kv1.2, Kv1.4, Kv1.5, Kv2.1, and Kv4.2, were expressed at significant levels in cardiac muscle. In comparisons of atrial and ventricular RNA samples, transcripts from the Kv1.2 and Kv4.2 genes showed the largest differences in relative abundance. There was an approximately twofold decrease in total Kv4 subfamily mRNA expression in atrial muscle relative to ventricular muscle and a 70% increase in total Kv1 subfamily mRNA. Variation of potassium channel mRNA expression within the left ventricular wall was also examined. There was a large gradient of Kv4.2 expression across the ventricular wall, and Kv4.2 expression in epicardial muscle was more than eight times higher than in papillary muscle. Other potassium channel genes were expressed at relatively uniform levels across the ventricular wall. The results suggest that transcriptional regulation makes a significant contribution to the control of potassium channel expression in cardiac muscle and to the variation of the electrophysiological phenotype of myocytes from different regions of the myocardium.

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				W. Guo, K. Kamiya, K. Yasui, I. Kodama, and J. Toyama Paracrine hypertrophic factors from cardiac non-myocyte cells downregulate the transient outward current density and Kv4.2 K+ channel expression in cultured rat cardiomyocytes Cardiovasc Res, January 1, 1999; 41(1): 157 - 165. [Abstract] [Full Text] [PDF]

				J.-F. Faivre, T. P.G. Calmels, S. Rouanet, J.-L. Javre, B. Cheval, and A. Bril Characterisation of Kv4.3 in HEK293 cells: comparison with the rat ventricular transient outward potassium current Cardiovasc Res, January 1, 1999; 41(1): 188 - 199. [Abstract] [Full Text] [PDF]

				L. Franqueza, C. Valenzuela, J. Eck, M.M. Tamkun, J. Tamargo, and D.J. Snyders Functional expression of an inactivating potassium channel (Kv4.3) in a mammalian cell line Cardiovasc Res, January 1, 1999; 41(1): 212 - 219. [Abstract] [Full Text] [PDF]

				W. Kong, S. Po, T. Yamagishi, M. D. Ashen, G. Stetten, and G. F. Tomaselli Isolation and characterization of the human gene encoding Ito: further diversity by alternative mRNA splicing Am J Physiol Heart Circ Physiol, December 1, 1998; 275(6): H1963 - H1970. [Abstract] [Full Text] [PDF]

				Z. Wang, L. Yue, M. White, G. Pelletier, and S. Nattel Differential Distribution of Inward Rectifier Potassium Channel Transcripts in Human Atrium Versus Ventricle Circulation, December 1, 1998; 98(22): 2422 - 2428. [Abstract] [Full Text] [PDF]

				L. M. Pacioretty and R. F. Gilmour Jr. Restoration of transient outward current by norepinephrine in cultured canine cardiac myocytes Am J Physiol Heart Circ Physiol, November 1, 1998; 275(5): H1599 - H1605. [Abstract] [Full Text] [PDF]

				S. M. Bryant, X. Wan, S.J. Shipsey, and G. Hart Regional differences in the delayed rectifier current (IKr and IKs) contribute to the differences in action potential duration in basal left ventricular myocytes in guinea-pig Cardiovasc Res, November 1, 1998; 40(2): 322 - 331. [Abstract] [Full Text] [PDF]

				A. Nishiyama, F. Kambe, K. Kamiya, H. Seo, and J. Toyama Effects of thyroid status on expression of voltage-gated potassium channels in rat left ventricle Cardiovasc Res, November 1, 1998; 40(2): 343 - 351. [Abstract] [Full Text] [PDF]

				S. Kaab, J. Dixon, J. Duc, D. Ashen, M. Nabauer, D. J. Beuckelmann, G. Steinbeck, D. McKinnon, and G. F. Tomaselli Molecular Basis of Transient Outward Potassium Current Downregulation in Human Heart Failure : A Decrease in Kv4.3 mRNA Correlates With a Reduction in Current Density Circulation, October 6, 1998; 98(14): 1383 - 1393. [Abstract] [Full Text] [PDF]

				J. Feng, L. Yue, Z. Wang, and S. Nattel Ionic Mechanisms of Regional Action Potential Heterogeneity in the Canine Right Atrium Circ. Res., September 7, 1998; 83(5): 541 - 551. [Abstract] [Full Text] [PDF]

				D. M. Barry, H. Xu, R. B. Schuessler, and J. M. Nerbonne Functional Knockout of the Transient Outward Current, Long-QT Syndrome, and Cardiac Remodeling in Mice Expressing a Dominant-Negative Kv4 {alpha} Subunit Circ. Res., September 7, 1998; 83(5): 560 - 567. [Abstract] [Full Text] [PDF]