Cardiovascular development. Prospects for a genetic approach

Table of Contents | Next Article »

Circulation Research. 1994;74:757-763

This Article

	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted
	Citation Map

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager
	Request Permissions

Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Fishman, M. C.
	Articles by Stainier, D. Y.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Fishman, M. C.
	Articles by Stainier, D. Y.

ARTICLES

Cardiovascular development. Prospects for a genetic approach

MC Fishman and DY Stainier
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown 02129.

Genetics is a powerful tool, especially when used in combination with embryology, in the seeking of genes necessary for assembly of the cardiovasculature. The first questions must address the types of cellular decisions that are made during development. As for simpler systems in C elegans and D melanogaster, the lineage and cell-fate decisions of the cardiovascular progenitors need to be assessed. In addition it is likely that new paradigms will emerge for multicellular assembly. The study of cardiovascular mutations will define individual genetic steps that define organotypic decisions. A genetic approach is a natural extension of embryology, physiology, and anatomy, fields of great sophistication with regard to the cardiovasculature, because, like them, it focuses on integrative biology and on the intact organism. The zebrafish is particularly well suited to a combination genetic-embryologic study of the fashioning of the cardiovasculature.

This article has been cited by other articles:

P. J. Schlueter and R. T. Peterson
Systematizing Serendipity for Cardiovascular Drug Discovery
Circulation, July 21, 2009; 120(3): 255 - 263.
[Full Text] [PDF]

F. H. Epstein and J. A. Epstein
A Perspective on the Value of Aquatic Models in Biomedical Research
Experimental Biology and Medicine, January 1, 2005; 230(1): 1 - 7.
[Abstract] [Full Text] [PDF]

J. M. Spitsbergen and M. L. Kent
The State of the Art of the Zebrafish Model for Toxicology and Toxicologic Pathology Research--Advantages and Current Limitations
Toxicol Pathol, January 1, 2003; 31(1_suppl): 62 - 87.
[Abstract] [PDF]

D. B. Cines, E. S. Pollak, C. A. Buck, J. Loscalzo, G. A. Zimmerman, R. P. McEver, J. S. Pober, T. M. Wick, B. A. Konkle, B. S. Schwartz, et al.
Endothelial Cells in Physiology and in the Pathophysiology of Vascular Disorders
Blood, May 15, 1998; 91(10): 3527 - 3561.
[Full Text] [PDF]

Q. Lin, J. Schwarz, C. Bucana, and E. N. Olson
Control of Mouse Cardiac Morphogenesis and Myogenesis by Transcription Factor MEF2C
Science, May 30, 1997; 276(5317): 1404 - 1407.
[Abstract] [Full Text]

J. Chen, F. van Eeden, K. Warren, A Chin, C Nusslein-Volhard, P Haffter, and M. Fishman
Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish
Development, January 11, 1997; 124(21): 4373 - 4382.
[Abstract] [PDF]

M. Fishman and K. Chien
Fashioning the vertebrate heart: earliest embryonic decisions
Development, January 6, 1997; 124(11): 2099 - 2117.
[Abstract] [PDF]

J. Chen, P Haffter, J Odenthal, E Vogelsang, M Brand, F. van Eeden, M Furutani-Seiki, M Granato, M Hammerschmidt, C. Heisenberg, et al.
Mutations affecting the cardiovascular system and other internal organs in zebrafish
Development, January 12, 1996; 123(1): 293 - 302.
[Abstract] [PDF]

E. Knapik, A Goodman, O. Atkinson, C. Roberts, M Shiozawa, C. Sim, S Weksler-Zangen, M. Trolliet, C Futrell, B. Innes, et al.
A reference cross DNA panel for zebrafish (Danio rerio) anchored with simple sequence length polymorphisms
Development, January 12, 1996; 123(1): 451 - 460.
[Abstract] [PDF]

				F. H. Epstein and J. A. Epstein A Perspective on the Value of Aquatic Models in Biomedical Research Experimental Biology and Medicine, January 1, 2005; 230(1): 1 - 7. [Abstract] [Full Text] [PDF]

				J. M. Spitsbergen and M. L. Kent The State of the Art of the Zebrafish Model for Toxicology and Toxicologic Pathology Research--Advantages and Current Limitations Toxicol Pathol, January 1, 2003; 31(1_suppl): 62 - 87. [Abstract] [PDF]

				D. B. Cines, E. S. Pollak, C. A. Buck, J. Loscalzo, G. A. Zimmerman, R. P. McEver, J. S. Pober, T. M. Wick, B. A. Konkle, B. S. Schwartz, et al. Endothelial Cells in Physiology and in the Pathophysiology of Vascular Disorders Blood, May 15, 1998; 91(10): 3527 - 3561. [Full Text] [PDF]

				Q. Lin, J. Schwarz, C. Bucana, and E. N. Olson Control of Mouse Cardiac Morphogenesis and Myogenesis by Transcription Factor MEF2C Science, May 30, 1997; 276(5317): 1404 - 1407. [Abstract] [Full Text]

				J. Chen, F. van Eeden, K. Warren, A Chin, C Nusslein-Volhard, P Haffter, and M. Fishman Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish Development, January 11, 1997; 124(21): 4373 - 4382. [Abstract] [PDF]

				M. Fishman and K. Chien Fashioning the vertebrate heart: earliest embryonic decisions Development, January 6, 1997; 124(11): 2099 - 2117. [Abstract] [PDF]

				J. Chen, P Haffter, J Odenthal, E Vogelsang, M Brand, F. van Eeden, M Furutani-Seiki, M Granato, M Hammerschmidt, C. Heisenberg, et al. Mutations affecting the cardiovascular system and other internal organs in zebrafish Development, January 12, 1996; 123(1): 293 - 302. [Abstract] [PDF]

				E. Knapik, A Goodman, O. Atkinson, C. Roberts, M Shiozawa, C. Sim, S Weksler-Zangen, M. Trolliet, C Futrell, B. Innes, et al. A reference cross DNA panel for zebrafish (Danio rerio) anchored with simple sequence length polymorphisms Development, January 12, 1996; 123(1): 451 - 460. [Abstract] [PDF]