Circulation Research, Vol 73, 792-796, Copyright © 1993 by American Heart Association

ARTICLES

Mouse model of arterial injury

V Lindner, J Fingerle and MA Reidy
Department of Pathology, University of Washington School of Medicine, Seattle.

In the present study, we established an injury model of the mouse carotid artery. Complete removal of the endothelium was achieved with a flexible wire. A platelet monolayer covered the denuded surface, and damage to underlying medial smooth muscle cells (SMCs) was detected. Injection of [3H]thymidine was used to determine the replication index for medial SMCs, which was found to be 1.6% at 2 days after denudation and 9.8% at 5 days. SMCs were observed in the intima by day 8 (replication index, 66%), and by 2 weeks the intimal lesion had a similar cell content as the media. In most animals, repair of the endothelial lining was complete 3 weeks after injury. The present model will allow us to use transgenic animals to address questions relevant to vascular biology and atherosclerosis.

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				S. R. Bryant, R. J. Bjercke, D. A. Erichsen, A. Rege, and V. Lindner Vascular Remodeling in Response to Altered Blood Flow Is Mediated by Fibroblast Growth Factor-2 Circ. Res., February 19, 1999; 84(3): 323 - 328. [Abstract] [Full Text] [PDF]

				K. Harada, I. Komuro, T. Sugaya, K. Murakami, and Y. Yazaki Vascular Injury Causes Neointimal Formation in Angiotensin II Type 1a Receptor Knockout Mice Circ. Res., February 5, 1999; 84(2): 179 - 185. [Abstract] [Full Text] [PDF]

				S. Kikuchi, K. Umemura, K. Kondo, A. R. Saniabadi, and M. Nakashima Photochemically Induced Endothelial Injury in the Mouse as a Screening Model for Inhibitors of Vascular Intimal Thickening Arterioscler Thromb Vasc Biol, July 1, 1998; 18(7): 1069 - 1078. [Abstract] [Full Text] [PDF]

				P. Carmeliet, L. Moons, and D. Collen Mouse models of angiogenesis, arterial stenosis, atherosclerosis and hemostasis Cardiovasc Res, July 1, 1998; 39(1): 8 - 33. [Abstract] [Full Text] [PDF]

				A. Kumar, J. L. Hoover, C. A. Simmons, V. Lindner, and R. J. Shebuski Remodeling and Neointimal Formation in the Carotid Artery of Normal and P-Selectin–Deficient Mice Circulation, December 16, 1997; 96(12): 4333 - 4342. [Abstract] [Full Text]

				B. De Geest, Z. Zhao, D. Collen, and P. Holvoet Effects of Adenovirus-Mediated Human Apo A-I Gene Transfer on Neointima Formation After Endothelial Denudation in Apo E–Deficient Mice Circulation, December 16, 1997; 96(12): 4349 - 4356. [Abstract] [Full Text]

				P. Carmeliet, L. Moons, J.-M. Herbert, J. Crawley, F. Lupu, R. Lijnen, and D. Collen Urokinase but Not Tissue Plasminogen Activator Mediates Arterial Neointima Formation in Mice Circ. Res., November 19, 1997; 81(5): 829 - 839. [Abstract] [Full Text]

				P. Carmeliet, L. Moons, R. Lijnen, S. Janssens, F. Lupu, D. Collen, and R. D. Gerard Inhibitory Role of Plasminogen Activator Inhibitor-1 in Arterial Wound Healing and Neointima Formation : A Gene Targeting and Gene Transfer Study in Mice Circulation, November 4, 1997; 96(9): 3180 - 3191. [Abstract] [Full Text]

				A. Kumar and V. Lindner Remodeling With Neointima Formation in the Mouse Carotid Artery After Cessation of Blood Flow Arterioscler Thromb Vasc Biol, October 1, 1997; 17(10): 2238 - 2244. [Abstract] [Full Text]

				J. M. Bosmans, M. M. Kockx, C. J. Vrints, H. Bult, G. R. Y. De Meyer, and A. G. Herman Fibrin(ogen) and von Willebrand Factor Deposition Are Associated With Intimal Thickening After Balloon Angioplasty of the Rabbit Carotid Artery Arterioscler Thromb Vasc Biol, April 1, 1997; 17(4): 634 - 645. [Abstract] [Full Text]

				C. I. Berul, M. J. Aronovitz, P. J. Wang, and M. E. Mendelsohn In Vivo Cardiac Electrophysiology Studies in the Mouse Circulation, November 15, 1996; 94(10): 2641 - 2648. [Abstract] [Full Text]

				V. Lindner and M. A. Reidy Expression of VEGF Receptors in Arteries After Endothelial Injury and Lack of Increased Endothelial Regrowth in Response to VEGF Arterioscler Thromb Vasc Biol, November 1, 1996; 16(11): 1399 - 1405. [Abstract] [Full Text]

				R. L. Levine, S.-J. Chen, J. Durand, Y.-F. Chen, and S. Oparil Medroxyprogesterone Attenuates Estrogen-Mediated Inhibition of Neointima Formation After Balloon Injury of the Rat Carotid Artery Circulation, November 1, 1996; 94(9): 2221 - 2227. [Abstract] [Full Text]