Diminished basal nitric oxide release after myocardial ischemia and reperfusion promotes neutrophil adherence to coronary endothelium

« Previous Article | Table of Contents | Next Article »

Circulation Research. 1993;72:403-412

This Article

	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted
	Citation Map

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager
	Request Permissions

Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Ma, X. L.
	Articles by Lefer, A. M.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Ma, X. L.
	Articles by Lefer, A. M.

ARTICLES

Diminished basal nitric oxide release after myocardial ischemia and reperfusion promotes neutrophil adherence to coronary endothelium

XL Ma, AS Weyrich, DJ Lefer and AM Lefer
Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107-6799.

We measured changes in basal release of nitric oxide and its effect on polymorphonuclear leukocyte (PMN) adherence to endothelial cells (ECs) in a feline model of myocardial ischemia (90 minutes) and reperfusion. Basal release of nitric oxide from the left anterior descending coronary artery (LAD) after myocardial ischemia/reperfusion and from the control left circumflex coronary artery (LCX) was assessed by NG- nitro L-arginine methyl ester (L-NAME)-induced vasocontraction. L-NAME induced a significant EC-dependent vasocontraction in control LCX rings (0.28 +/- 0.04 g), which was fully reversed by L-arginine but not D- arginine. L-NAME-induced vasocontraction of LAD rings was not significantly changed after 90 minutes of myocardial ischemia without reperfusion. However, 10 minutes of reperfusion reduced the L-NAME- induced vasocontraction to 0.13 +/- 0.04 g (p < 0.05), and this was restored by addition of 3 mM L-arginine but not D-arginine. Longer periods of reperfusion progressively decreased L-NAME-induced vasocontraction. After 270 minutes of reperfusion, L-NAME-induced vasocontraction was virtually abolished. Myocardial ischemia without reperfusion did not increase PMN adherence to ECs. However, PMN adherence to LAD ECs was significantly increased after 20 minutes of reperfusion (39 +/- 6 to 105 +/- 9 PMNs/mm2, p < 0.01), and incubation of LAD segments with L-arginine significantly attenuated this increase in PMN adherence. After 270 minutes of reperfusion, PMN adherence to LAD ECs was further increased to 224 +/- 10 PMNs/mm2 (p < 0.001). This increase in PMN adherence was almost completely blocked by MAb R15.7, a monoclonal antibody against CD18 of PMNs, and was significantly attenuated by MAb RR1/1, a monoclonal antibody against intercellular adhesion molecule-1 of ECs (p < 0.01). These results indicate that decreased basal release of endothelium-derived relaxing factor after myocardial ischemia/reperfusion precedes enhanced PMN adherence to the coronary endothelium, which may lead to PMN-induced myocardial injury.

This article has been cited by other articles:

M. V. Badiwala, D. Ramzy, L. C. Tumiati, E. D. Tepperman, R. Sheshgiri, J. L. Prodger, C. M. Feindel, and V. Rao
Donor Pretreatment With Hypertonic Saline Attenuates Primary Allograft Dysfunction: A Pilot Study in a Porcine Model
Circulation, September 15, 2009; 120(11_suppl_1): S206 - S214.
[Abstract] [Full Text] [PDF]

J. W. Calvert and D. J. Lefer
Myocardial protection by nitrite
Cardiovasc Res, July 15, 2009; 83(2): 195 - 203.
[Abstract] [Full Text] [PDF]

J. W. Calvert, S. Gundewar, S. Jha, J. J.M. Greer, W. H. Bestermann, R. Tian, and D. J. Lefer
Acute Metformin Therapy Confers Cardioprotection Against Myocardial Infarction Via AMPK-eNOS-Mediated Signaling
Diabetes, March 1, 2008; 57(3): 696 - 705.
[Abstract] [Full Text] [PDF]

R. M. Mentzer Jr, M. S. Jahania, and R. D. Lasley
Myocardial Protection
Card. Surg. Adult, January 1, 2008; 3(2008): 443 - 464.
[Full Text]

N. S. Bryan, J. W. Calvert, J. W. Elrod, S. Gundewar, S. Y. Ji, and D. J. Lefer
Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury
PNAS, November 27, 2007; 104(48): 19144 - 19149.
[Abstract] [Full Text] [PDF]

M. C. Stuhlinger, E. Conci, B. J. Haubner, E.-M. Stocker, J. Schwaighofer, J. P. Cooke, P. S. Tsao, O. Pachinger, and B. Metzler
Asymmetric Dimethyl L-Arginine (ADMA) is a critical regulator of myocardial reperfusion injury
Cardiovasc Res, July 15, 2007; 75(2): 417 - 425.
[Abstract] [Full Text] [PDF]

Z.-Q. Zhao and J. Vinten-Johansen
Postconditioning: Reduction of reperfusion-induced injury
Cardiovasc Res, May 1, 2006; 70(2): 200 - 211.
[Abstract] [Full Text] [PDF]

D. R. Bell and K. Gochenaur
Direct vasoactive and vasoprotective properties of anthocyanin-rich extracts
J Appl Physiol, April 1, 2006; 100(4): 1164 - 1170.
[Abstract] [Full Text] [PDF]

D. Omiyi, R. J. Brue, P. Taormina II, M. Harvey, N. Atkinson, and L. H. Young
Protein Kinase C {beta}II Peptide Inhibitor Exerts Cardioprotective Effects in Rat Cardiac Ischemia/Reperfusion Injury
J. Pharmacol. Exp. Ther., August 1, 2005; 314(2): 542 - 551.
[Abstract] [Full Text] [PDF]

S. Das, A. Tosaki, D. Bagchi, N. Maulik, and D. K. Das
Resveratrol-Mediated Activation of cAMP Response Element-Binding Protein through Adenosine A3 Receptor by Akt-Dependent and -Independent Pathways
J. Pharmacol. Exp. Ther., August 1, 2005; 314(2): 762 - 769.
[Abstract] [Full Text] [PDF]

J Trevelyan, E W A Needham, A Morris, and R K Mattu
Comparison of the effect of enalapril and losartan in conjunction with surgical coronary revascularisation versus revascularisation alone on systemic endothelial function
Heart, August 1, 2005; 91(8): 1053 - 1057.
[Abstract] [Full Text] [PDF]

A. Phillipson, E. E. Peterman, P. Taormina Jr., M. Harvey, R. J. Brue, N. Atkinson, D. Omiyi, U. Chukwu, and L. H. Young
Protein kinase C-{zeta} inhibition exerts cardioprotective effects in ischemia-reperfusion injury
Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H898 - H907.
[Abstract] [Full Text] [PDF]

P. J. Kuhlencordt, E. Rosel, R. E. Gerszten, M. Morales-Ruiz, D. Dombkowski, W. J. Atkinson, F. Han, F. Preffer, A. Rosenzweig, W. C. Sessa, et al.
Role of endothelial nitric oxide synthase in endothelial activation: insights from eNOS knockout endothelial cells
Am J Physiol Cell Physiol, May 1, 2004; 286(5): C1195 - C1202.
[Abstract] [Full Text] [PDF]

H. Kin, Z.-Q. Zhao, H.-Y. Sun, N.-P. Wang, J. S. Corvera, M. E. Halkos, F. Kerendi, R. A. Guyton, and J. Vinten-Johansen
Postconditioning attenuates myocardial ischemia-reperfusion injury by inhibiting events in the early minutes of reperfusion
Cardiovasc Res, April 1, 2004; 62(1): 74 - 85.
[Abstract] [Full Text] [PDF]

R. Schulz, M. Kelm, and G. Heusch
Nitric oxide in myocardial ischemia/reperfusion injury
Cardiovasc Res, February 15, 2004; 61(3): 402 - 413.
[Abstract] [Full Text] [PDF]

J. Vinten-Johansen
Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury
Cardiovasc Res, February 15, 2004; 61(3): 481 - 497.
[Abstract] [Full Text] [PDF]

M. Galinanes and A. G Fowler
Role of clinical pathologies in myocardial injury following ischaemia and reperfusion
Cardiovasc Res, February 15, 2004; 61(3): 512 - 521.
[Abstract] [Full Text] [PDF]

J. Gianetti, P. Del Sarto, S. Bevilacqua, C. Vassalle, R. De Filippis, M. Kacila, P. A. Farneti, A. Clerico, M. Glauber, and A. Biagini
Supplemental nitric oxide and its effect on myocardial injury and function in patients undergoing cardiac surgery with extracorporeal circulation
J. Thorac. Cardiovasc. Surg., January 1, 2004; 127(1): 44 - 50.
[Abstract] [Full Text] [PDF]

Y. Hayashi, Y. Sawa, N. Fukuyama, Y. Miyamoto, T. Takahashi, H. Nakazawa, and H. Matsuda
Leukocyte-depleted terminal blood cardioplegia provides superior myocardial protective effects in association with myocardium-derived nitric oxide and peroxynitrite production for patients undergoing prolonged aortic crossclamping for more than 120 minutes
J. Thorac. Cardiovasc. Surg., December 1, 2003; 126(6): 1813 - 1821.
[Abstract] [Full Text] [PDF]

C. L. Speyer, T. A. Neff, R. L. Warner, R.-F. Guo, J. V. Sarma, N. C. Riedemann, M. E. Murphy, H. S. Murphy, and P. A. Ward
Regulatory Effects of iNOS on Acute Lung Inflammatory Responses in Mice
Am. J. Pathol., December 1, 2003; 163(6): 2319 - 2328.
[Abstract] [Full Text]

B. Y. Poon, E. Raharjo, K. D. Patel, S. Tavener, and P. Kubes
Complexity of Inducible Nitric Oxide Synthase: Cellular Source Determines Benefit Versus Toxicity
Circulation, September 2, 2003; 108(9): 1107 - 1112.
[Abstract] [Full Text] [PDF]

Z.-Q. Zhao, J. S. Corvera, M. E. Halkos, F. Kerendi, N.-P. Wang, R. A. Guyton, and J. Vinten-Johansen
Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning
Am J Physiol Heart Circ Physiol, August 1, 2003; 285(2): H579 - H588.
[Abstract] [Full Text] [PDF]

K. Laude, J. Favre, C. Thuillez, and V. Richard
NO produced by endothelial NO synthase is a mediator of delayed preconditioning-induced endothelial protection
Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H2053 - H2060.
[Abstract] [Full Text] [PDF]

R. J. Reiter and D.-X. Tan
Melatonin: a novel protective agent against oxidative injury of the ischemic/reperfused heart
Cardiovasc Res, April 1, 2003; 58(1): 10 - 19.
[Abstract] [Full Text] [PDF]

R. M. Mentzer Jr., M. S. Jahania, and R. D. Lasley
Myocardial Protection
Card. Surg. Adult, January 1, 2003; 2(2003): 413 - 438.
[Full Text]

D. R. Bell, K. E. Gochenaur, and J. Hecht
O2--mediated impairment of coronary arterial relaxation is prevented by overnight treatment with 1 nM beta -estradiol
J Appl Physiol, December 1, 2002; 93(6): 1952 - 1958.
[Abstract] [Full Text] [PDF]

S. P. Jones, M. F. Gibson, D. M. Rimmer III, T. M. Gibson, B. R. Sharp, and D. J. Lefer
Direct vascular and cardioprotective effects of rosuvastatin, a new HMG-CoA reductase inhibitor
J. Am. Coll. Cardiol., September 18, 2002; 40(6): 1172 - 1178.
[Abstract] [Full Text] [PDF]

H. Ogita, K. Node, H. Asanuma, S. Sanada, Y. Liao, S. Takashima, M. Asakura, H. Mori, Y. Shinozaki, M. Hori, et al.
Amelioration of ischemia- and reperfusion-induced myocardial injury by the selective estrogen receptor modulator, raloxifene, in the canine heart
J. Am. Coll. Cardiol., September 4, 2002; 40(5): 998 - 1005.
[Abstract] [Full Text] [PDF]

R. Hattori, H. Otani, N. Maulik, and D. K. Das
Pharmacological preconditioning with resveratrol: role of nitric oxide
Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H1988 - H1995.
[Abstract] [Full Text] [PDF]

G. Imamura, A. A. Bertelli, A. Bertelli, H. Otani, N. Maulik, and D. K. Das
Pharmacological preconditioning with resveratrol: an insight with iNOS knockout mice
Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H1996 - H2003.
[Abstract] [Full Text] [PDF]

G. Booth, T. J. Stalker, A. M. Lefer, and R. Scalia
Mechanisms of Amelioration of Glucose-Induced Endothelial Dysfunction Following Inhibition of Protein Kinase C In Vivo
Diabetes, May 1, 2002; 51(5): 1556 - 1564.
[Abstract] [Full Text] [PDF]

M. Thielmann, H. Dorge, C. Martin, S. Belosjorow, U. Schwanke, A. van de Sand, I. Konietzka, A. Buchert, A. Kruger, R. Schulz, et al.
Myocardial Dysfunction With Coronary Microembolization: Signal Transduction Through a Sequence of Nitric Oxide, Tumor Necrosis Factor-{alpha}, and Sphingosine
Circ. Res., April 19, 2002; 90(7): 807 - 813.
[Abstract] [Full Text] [PDF]

R. M. Stevens, M. S. Jahania, J. E. Stivers, R. M. Mentzer Jr, and R. D. Lasley
Effects of in vivo myocardial ischemia and reperfusion on interstitial nitric oxide metabolites
Ann. Thorac. Surg., April 1, 2002; 73(4): 1261 - 1266.
[Abstract] [Full Text] [PDF]

Y. Ikeda, L. H. Young, and A. M. Lefer
Attenuation of neutrophil-mediated myocardial ischemia-reperfusion injury by a calpain inhibitor
Am J Physiol Heart Circ Physiol, April 1, 2002; 282(4): H1421 - H1426.
[Abstract] [Full Text] [PDF]

M. Ozaki, S. Kawashima, T. Hirase, T. Yamashita, M. Namiki, N. Inoue, K.-i. Hirata, and M. Yokoyama
Overexpression of Endothelial Nitric Oxide Synthase in Endothelial Cells Is Protective against Ischemia-Reperfusion Injury in Mouse Skeletal Muscle
Am. J. Pathol., April 1, 2002; 160(4): 1335 - 1344.
[Abstract] [Full Text] [PDF]

P. G. McLean, D. Aston, D. Sarkar, and A. Ahluwalia
Protease-Activated Receptor-2 Activation Causes EDHF-Like Coronary Vasodilation: Selective Preservation in Ischemia/Reperfusion Injury: Involvement of Lipoxygenase Products, VR1 Receptors, and C-Fibers
Circ. Res., March 8, 2002; 90(4): 465 - 472.
[Abstract] [Full Text] [PDF]

Z. Qian, R. Gelzer-Bell, S.-x. Yang, W. Cao, T. Ohnishi, B. A. Wasowska, R. H. Hruban, E. R. Rodriguez, W. M. Baldwin III, and C. J. Lowenstein
Inducible Nitric Oxide Synthase Inhibition of Weibel-Palade Body Release in Cardiac Transplant Rejection
Circulation, November 6, 2001; 104(19): 2369 - 2375.
[Abstract] [Full Text] [PDF]

J. R. Kersten, W. G. Toller, J. P. Tessmer, P. S. Pagel, and D. C. Warltier
Hyperglycemia reduces coronary collateral blood flow through a nitric oxide-mediated mechanism
Am J Physiol Heart Circ Physiol, November 1, 2001; 281(5): H2097 - H2104.
[Abstract] [Full Text] [PDF]

Y. Hayashi, Y. Sawa, S. Ohtake, N. Fukuyama, H. Nakazawa, and H. Matsuda
Peroxynitrite formation from human myocardium after ischemia-reperfusion during open heart operation
Ann. Thorac. Surg., August 1, 2001; 72(2): 571 - 576.
[Abstract] [Full Text] [PDF]

A. Gourine, A. Gonon, P.-O. Sjoquist, and J. Pernow
Short-acting calcium antagonist clevidipine protects against reperfusion injury via local nitric oxide-related mechanisms in the jeopardised myocardium
Cardiovasc Res, July 1, 2001; 51(1): 100 - 107.
[Abstract] [Full Text] [PDF]

L. H. Young, Y. Ikeda, and A. M. Lefer
Caveolin-1 peptide exerts cardioprotective effects in myocardial ischemia-reperfusion via nitric oxide mechanism
Am J Physiol Heart Circ Physiol, June 1, 2001; 280(6): H2489 - H2495.
[Abstract] [Full Text] [PDF]

T. de Frutos, L. Sanchez de Miguel, J. Farre, J. Gomez, J. Romero, P. Marcos-Alberca, A. Nunez, L. Rico, and A. Lopez-Farre
Expression of an endothelial-type nitric oxide synthase isoform in human neutrophils: modification by tumor necrosis factor-alpha and during acute myocardial infarction
J. Am. Coll. Cardiol., March 1, 2001; 37(3): 800 - 807.
[Abstract] [Full Text] [PDF]

E. Di Carlo, G. Forni, P. Lollini, M. P. Colombo, A. Modesti, and P. Musiani
The intriguing role of polymorphonuclear neutrophils in antitumor reactions
Blood, January 15, 2001; 97(2): 339 - 345.
[Full Text] [PDF]

Y. Ikeda, L. H Young, R. Scalia, C. R Ross, and A. M Lefer
PR-39, a proline/arginine-rich antimicrobial peptide, exerts cardioprotective effects in myocardial ischemia-reperfusion
Cardiovasc Res, January 1, 2001; 49(1): 69 - 77.
[Abstract] [Full Text] [PDF]

L. H. Young, Y. Ikeda, R. Scalia, and A. M. Lefer
Wortmannin, a Potent Antineutrophil Agent, Exerts Cardioprotective Effects in Myocardial Ischemia/Reperfusion
J. Pharmacol. Exp. Ther., October 1, 2000; 295(1): 37 - 43.
[Abstract] [Full Text]

L. H. Young, Y. Ikeda, R. Scalia, and A. M. Lefer
C-peptide exerts cardioprotective effects in myocardial ischemia-reperfusion
Am J Physiol Heart Circ Physiol, October 1, 2000; 279(4): H1453 - H1459.
[Abstract] [Full Text] [PDF]

N. Hayashida, S. Chihara, E. Tayama, S. Yokose, K. Akasu, E. Kai, and S. Aoyagi
Effects of angiotensin-converting enzyme inhibitor during warm blood cardioplegia
Ann. Thorac. Surg., August 1, 2000; 70(2): 627 - 632.
[Abstract] [Full Text] [PDF]

J. A Barrabes, D. Garcia-Dorado, B. Soriano, J. Solares, Y. Puigfel, L. Trobo, A. Garcia-Lafuente, and J. Soler-Soler
Dynamic intracoronary thrombosis does not cause significant downstream platelet embolization
Cardiovasc Res, August 1, 2000; 47(2): 265 - 273.
[Abstract] [Full Text] [PDF]

D.-M. McCafferty, E. Sihota, M. Muscara, J. L. Wallace, K. A. Sharkey, and P. Kubes
Spontaneously developing chronic colitis in IL-10/iNOS double-deficient mice
Am J Physiol Gastrointest Liver Physiol, July 1, 2000; 279(1): G90 - G99.
[Abstract] [Full Text] [PDF]

Y.-P. Sun, N. C. Lu, W. W. Parmley, and C. B. Hollenbeck
Effects of Cholesterol Diets on Vascular Function and Atherogenesis in Rabbits
Experimental Biology and Medicine, July 1, 2000; 224(3): 166 - 171.
[Abstract] [Full Text]

H. I. Magazine, J. Chang, Y. Goumon, and G. B. Stefano
Rebound from Nitric Oxide Inhibition Triggers Enhanced Monocyte Activation and Chemotaxis
J. Immunol., July 1, 2000; 165(1): 102 - 107.
[Abstract] [Full Text] [PDF]

S. CUZZOCREA, T. P. MISKO, G. COSTANTINO, E. MAZZON, A. MICALI, A. P. CAPUTI, H. MACARTHUR, and D. SALVEMINI
Beneficial effects of peroxynitrite decomposition catalyst in a rat model of splanchnic artery occlusion and reperfusion
FASEB J, June 1, 2000; 14(9): 1061 - 1072.
[Abstract] [Full Text]

R. Neviere, B. Guery, S. Mordon, F. Zerimech, S. Charre, F. Wattel, and C. Chopin
Inhaled NO reduces leukocyte-endothelial cell interactions and myocardial dysfunction in endotoxemic rats
Am J Physiol Heart Circ Physiol, June 1, 2000; 278(6): H1783 - H1790.
[Abstract] [Full Text] [PDF]

R. R. Giraldez, A. Panda, and J. L. Zweier
Endothelial dysfunction does not require loss of endothelial nitric oxide synthase
Am J Physiol Heart Circ Physiol, June 1, 2000; 278(6): H2020 - H2027.
[Abstract] [Full Text] [PDF]

Y. Liu, Q. Wang, X. Zhu, D. Liu, S. Pan, Y. Ruan, and Y. Li
Pulmonary artery perfusion with protective solution reduces lung injury after cardiopulmonary bypass
Ann. Thorac. Surg., May 1, 2000; 69(5): 1402 - 1407.
[Abstract] [Full Text] [PDF]

H. Fraser, S. T. Davidge, and A. S. Clanachan
Activation of Ca2+-independent nitric oxide synthase by 17{beta}-estradiol in post-ischemic rat heart
Cardiovasc Res, April 1, 2000; 46(1): 111 - 118.
[Abstract] [Full Text] [PDF]

W. A. Cooper, I. G. Duarte, V. H. Thourani, M. Nakamura, N.-P. Wang, W. M. Brown III, J. P. Gott, J. Vinten-Johansen, and R. A. Guyton
Hypothermic circulatory arrest causes multisystem vascular endothelial dysfunction and apoptosis
Ann. Thorac. Surg., March 1, 2000; 69(3): 696 - 702.
[Abstract] [Full Text] [PDF]

T. Suda, B. N. Mora, F. D�Ovidio, J. A. Cooper, M. Hiratsuka, W. Zhang, T. Mohanakumar, and G. A. Patterson
IN VIVO ADENOVIRUS-MEDIATED ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE TRANSFER AMELIORATES LUNG ALLOGRAFT ISCHEMIA-REPERFUSION INJURY
J. Thorac. Cardiovasc. Surg., February 1, 2000; 119(2): 297 - 304.
[Abstract] [Full Text] [PDF]

M. KAKOKI, Y. HIRATA, H. HAYAKAWA, E. SUZUKI, D. NAGATA, A. TOJO, H. NISHIMATSU, N. NAKANISHI, Y. HATTORI, K. KIKUCHI, et al.
Effects of Tetrahydrobiopterin on Endothelial Dysfunction in Rats with Ischemic Acute Renal Failure
J. Am. Soc. Nephrol., February 1, 2000; 11(2): 301 - 309.
[Abstract] [Full Text] [PDF]

S. Hoshida, N. Yamashita, K. Otsu, T. Kuzuya, and M. Hori
Cholesterol feeding exacerbates myocardial injury in Zucker diabetic fatty rats
Am J Physiol Heart Circ Physiol, January 1, 2000; 278(1): H256 - H262.
[Abstract] [Full Text] [PDF]

R. S Ronson, M. Nakamura, and J. Vinten-Johansen
The cardiovascular effects and implications of peroxynitrite
Cardiovasc Res, October 1, 1999; 44(1): 47 - 59.
[Abstract] [Full Text] [PDF]

J. E. Jordan, Z.-Q. Zhao, and J. Vinten-Johansen
The role of neutrophils in myocardial ischemia-reperfusion injury
Cardiovasc Res, September 1, 1999; 43(4): 860 - 878.
[Abstract] [Full Text] [PDF]

V. Stangl, O. Rodiger, T. M. Frank, M. Bohm, K. Stangl, G. Baumann, and S. B. Felix
Influence of polymorphonuclear leukocytes and plasma on coronary vasomotion after ischemia
Ann. Thorac. Surg., August 1, 1999; 68(2): 442 - 446.
[Abstract] [Full Text] [PDF]

B. Guery, R. Neviere, N. Viget, C. Foucher, P. Fialdes, F. Wattel, and G. Beaucaire
Inhaled NO preadministration modulates local and remote ischemia-reperfusion organ injury in a rat model
J Appl Physiol, July 1, 1999; 87(1): 47 - 53.
[Abstract] [Full Text] [PDF]

X.-P. Yang, Y.-H. Liu, E. G. Shesely, M. Bulagannawar, F. Liu, and O. A. Carretero
Endothelial Nitric Oxide Gene Knockout Mice : Cardiac Phenotypes and the Effect of Angiotensin-Converting Enzyme Inhibitor on Myocardial Ischemia/Reperfusion Injury
Hypertension, July 1, 1999; 34(1): 24 - 30.
[Abstract] [Full Text] [PDF]

R. J. Hendrickson, P. A. Cahill, J. V. Sitzmann, and E. M. Redmond
Ethanol Enhances Basal and Flow-Stimulated Nitric Oxide Synthase Activity In Vitro by Activating an Inhibitory Guanine Nucleotide Binding Protein
J. Pharmacol. Exp. Ther., June 1, 1999; 289(3): 1293 - 1300.
[Abstract] [Full Text]

I. Tritto and G. Ambrosio
Spotlight on microcirculation: an update
Cardiovasc Res, June 1, 1999; 42(3): 600 - 606.
[Full Text] [PDF]

Y. SATO, K.�R. WALLEY, M.�E. KLUT, D. ENGLISH, Y. D'YACHKOVA, J.�C. HOGG, and S.�F. van EEDEN
Nitric Oxide Reduces the Sequestration of Polymorphonuclear Leukocytes in Lung by Changing Deformability and CD18 Expression
Am. J. Respir. Crit. Care Med., May 1, 1999; 159(5): 1469 - 1476.
[Abstract] [Full Text] [PDF]

P. C. Kouretas, Y. D. Kim, P. A. Cahill, A. K. Myers, L. N. To, Y.-N. Wang, J. V. Sitzmann, and R. L. Hannan
Nonanticoagulant Heparin Prevents Coronary Endothelial Dysfunction After Brief Ischemia-Reperfusion Injury in the Dog
Circulation, March 2, 1999; 99(8): 1062 - 1068.
[Abstract] [Full Text] [PDF]

S. Hoshida, N. Yamashita, K. Kawahara, T. Kuzuya, and M. Hori
Amelioration by Quinapril of Myocardial Infarction Induced by Coronary Occlusion/Reperfusion in a Rabbit Model of Atherosclerosis : Possible Mechanisms
Circulation, January 26, 1999; 99(3): 434 - 440.
[Abstract] [Full Text] [PDF]

M. Tofukuji, C. Metais, C. D. Collard, D. S. Morse, G. L. Stahl, D. P. Nelson, J. Li, M. Simons, and F. W. Sellke
Effect of sialyl Lewisx oligosaccharide on myocardial and cerebral injury in the pig
Ann. Thorac. Surg., January 1, 1999; 67(1): 112 - 119.
[Abstract] [Full Text] [PDF]

R. Hayward, B. Campbell, Y. K Shin, R. Scalia, and A. M Lefer
Recombinant soluble P-selectin glycoprotein ligand-1 protects against myocardial ischemic reperfusion injury in cats
Cardiovasc Res, January 1, 1999; 41(1): 65 - 76.
[Abstract] [Full Text] [PDF]

G.-L. Liu, T. A. Christopher, B. L. Lopez, F. Gao, Y. Guo, E. Gao, K. Knuettel, M. Feelisch, and X. L. Ma
SP/W-5186, A Cysteine-Containing Nitric Oxide Donor, Attenuates Postischemic Myocardial Injury
J. Pharmacol. Exp. Ther., November 1, 1998; 287(2): 527 - 537.
[Abstract] [Full Text]

K. Takada, K. Yamashita, Y. Sakurai-Yamashita, K. Shigematsu, Y. Hamada, K. Hioki, and K. Taniyama
Participation of Nitric Oxide in the Mucosal Injury of Rat Intestine Induced by Ischemia-Reperfusion
J. Pharmacol. Exp. Ther., October 1, 1998; 287(1): 403 - 407.
[Abstract] [Full Text]

E. Mori, N. Haramaki, H. Ikeda, and T. Imaizumi
Intra-coronary administration of L-arginine aggravates myocardial stunning through production of peroxynitrite in dogs
Cardiovasc Res, October 1, 1998; 40(1): 113 - 113.
[Abstract] [Full Text] [PDF]

B. L. Bufkin, S. T. Shearer, J. Vinten-Johansen, I. G. Duarte, V. H. Thourani, M. Nakamura, Z.-Q. Zhao, and R. A. Guyton
Preconditioning during simulated MIDCABG attenuates blood flow defects and neutrophil accumulation
Ann. Thorac. Surg., September 1, 1998; 66(3): 726 - 732.
[Abstract] [Full Text] [PDF]

P. E. Parrino, V. E. Laubach, J. R. Gaughen Jr, K. S. Shockey, T.-A. Wattsman, R. C. King, C. G. Tribble, and I. L. Kron
Inhibition of inducible nitric oxide synthase after myocardial ischemia increases coronary flow
Ann. Thorac. Surg., September 1, 1998; 66(3): 733 - 739.
[Abstract] [Full Text] [PDF]

T. O. Nossuli, R. Hayward, D. Jensen, R. Scalia, and A. M. Lefer
Mechanisms of cardioprotection by peroxynitrite in myocardial ischemia and reperfusion injury
Am J Physiol Heart Circ Physiol, August 1, 1998; 275(2): H509 - H519.
[Abstract] [Full Text] [PDF]

K. Node, M. Kitakaze, H. Sato, Y. Koretsune, M. Karita, H. Kosaka, and M. Hori
Increased release of nitric oxide in ischemic hearts after exercise in patients with effort angina
J. Am. Coll. Cardiol., July 1, 1998; 32(1): 63 - 68.
[Abstract] [Full Text] [PDF]

M. Buerke, D. Prüfer, M. Dahm, H. Oelert, J. Meyer, and H. Darius
Blocking of Classical Complement Pathway Inhibits Endothelial Adhesion Molecule Expression and Preserves Ischemic Myocardium from Reperfusion Injury
J. Pharmacol. Exp. Ther., July 1, 1998; 286(1): 429 - 438.
[Abstract] [Full Text]

K. Node, M. Kitakaze, H. Kosaka, T. Minamino, H. Mori, and M. Hori
Role of Ca2+-Activated K+ Channels in the Protective Effect of ACE Inhibition Against Ischemic Myocardial Injury
Hypertension, June 1, 1998; 31(6): 1290 - 1298.
[Abstract] [Full Text] [PDF]

N. Okayama, H. Ichikawa, L. Coe, M. Itoh, and J. S. Alexander
Exogenous NO enhances hydrogen peroxide-mediated neutrophil adherence to cultured endothelial cells
Am J Physiol Lung Cell Mol Physiol, May 1, 1998; 274(5): L820 - L826.
[Abstract] [Full Text] [PDF]

S. C. Body and S. K. Shernan
The Utility of Nitric Oxide in the Postoperative Period
Seminars in Cardiothoracic and Vascular Anesthesia, March 1, 1998; 2(1): 4 - 30.
[Abstract] [PDF]

B. C. Sheridan, R. C. McIntyre Jr., D. R. Meldrum, and D. A. Fullerton
L-Arginine prevents lung neutrophil accumulation and preserves pulmonary endothelial function after endotoxin
Am J Physiol Lung Cell Mol Physiol, March 1, 1998; 274(3): L337 - L342.
[Abstract] [Full Text] [PDF]

J. T. Cope, D. Banks, V. E. Laubach, O. A. R. Binns, R. C. King, R. M. Richardson, K. S. Shockey, C. G. Tribble, and I. L. Kron
Sodium Nitroprusside Exacerbates Myocardial Ischemia-Reperfusion Injury
Ann. Thorac. Surg., December 1, 1997; 64(6): 1656 - 1659.
[Abstract] [Full Text]

M. A. Banda, D. J. Lefer, and D. N. Granger
Postischemic endothelium-dependent vascular reactivity is preserved in adhesion molecule-deficient mice
Am J Physiol Heart Circ Physiol, December 1, 1997; 273(6): H2721 - H2725.
[Abstract] [Full Text] [PDF]

Y. Horie, R. Wolf, and D. N. Granger
Role of nitric oxide in gut ischemia-reperfusion-induced hepatic microvascular dysfunction
Am J Physiol Gastrointest Liver Physiol, November 1, 1997; 273(5): G1007 - G1013.
[Abstract] [Full Text] [PDF]

N. Kaeffer, V. Richard, and C. Thuillez
Delayed Coronary Endothelial Protection 24 Hours After Preconditioning : Role of Free Radicals
Circulation, October 7, 1997; 96(7): 2311 - 2316.
[Abstract] [Full Text]

T. O. Nossuli, R. Hayward, R. Scalia, and A. M. Lefer
Peroxynitrite Reduces Myocardial Infarct Size and Preserves Coronary Endothelium After Ischemia and Reperfusion in Cats
Circulation, October 7, 1997; 96(7): 2317 - 2324.
[Abstract] [Full Text]

Z. Zuo and R. A. Johns
Inhalational Anesthetics Up-Regulate Constitutive and Lipopolysaccharide-Induced Inducible Nitric Oxide Synthase Expression and Activity
Mol. Pharmacol., October 1, 1997; 52(4): 606 - 612.
[Abstract] [Full Text]

R. Kacimi, C. S. Long, and J. S. Karliner
Chronic Hypoxia Modulates the Interleukin-1ߖStimulated Inducible Nitric Oxide Synthase Pathway in Cardiac Myocytes
Circulation, September 16, 1997; 96(6): 1937 - 1943.
[Abstract] [Full Text]

K. Node, M. Kitakaze, H. Kosaka, T. Minamino, H. Funaya, and M. Hori
Amelioration of Ischemia- and Reperfusion-Induced Myocardial Injury by 17�-Estradiol : Role of Nitric Oxide and Calcium-Activated Potassium Channels
Circulation, September 16, 1997; 96(6): 1953 - 1963.
[Abstract] [Full Text]

R. Scalia, J. Gefen, N. A. Petasis, C. N. Serhan, and A. M. Lefer
Lipoxin A4 stable analogs inhibit leukocyte rolling and adherence in the rat mesenteric microvasculature: Role of�P-selectin
PNAS, September 2, 1997; 94(18): 9967 - 9972.
[Abstract] [Full Text] [PDF]

R. R. Giraldez, A. Panda, Y. Xia, S. P. Sanders, and J. L. Zweier
Decreased Nitric-oxide Synthase Activity Causes Impaired Endothelium-dependent Relaxation in the Postischemic Heart
J. Biol. Chem., August 22, 1997; 272(34): 21420 - 21426.
[Abstract] [Full Text] [PDF]

F. Dagenais, R. Cartier, C. Hollmann, and J. Buluran
Calcium-Channel Blockers Preserve Coronary Endothelial Reactivity After Ischemia-Reperfusion
Ann. Thorac. Surg., April 1, 1997; 63(4): 1050 - 1056.
[Abstract] [Full Text]

M. S. Bhabra, D. N. Hopkinson, T. E. Shaw, and T. L. Hooper
Low-Dose Nitric Oxide Inhalation During Initial Reperfusion Enhances Rat Lung Graft Function
Ann. Thorac. Surg., February 1, 1997; 63(2): 339 - 344.
[Abstract] [Full Text]

M. S. Bhabra, D. N. Hopkinson, T. E. Shaw, and T. L. Hooper
ATTENUATION OF LUNG GRAFT REPERFUSION INJURY BY A NITRIC OXIDE DONOR
J. Thorac. Cardiovasc. Surg., February 1, 1997; 113(2): 327 - 334.
[Abstract] [Full Text]

A. Mizuno, R. Baretti, G. D. Buckberg, H. H. Young, J. Vinten-Johansen, X.-L. Ma, and L. J. Ignarro
ENDOTHELIAL STUNNING AND MYOCYTE RECOVERY AFTER REPERFUSION OF JEOPARDIZED MUSCLE: A ROLE OF L-ARGININE BLOOD CARDIOPLEGIA
J. Thorac. Cardiovasc. Surg., February 1, 1997; 113(2): 379 - 389.
[Abstract] [Full Text]

H. Sato, Z.-Q. Zhao, J. E. Jordan, J. C. Todd, R. D. Riley, C. S. Taft, J. W. Hammon Jr., P. Li, X.-l. Ma, and J. Vinten-Johansen
BASAL NITRIC OXIDE EXPRESSES ENDOGENOUS CARDIOPROTECTION DURING REPERFUSION BY INHIBITION OF NEUTROPHIL-MEDIATED DAMAGE AFTER SURGICAL REVASCULARIZATION
J. Thorac. Cardiovasc. Surg., February 1, 1997; 113(2): 399 - 409.
[Abstract] [Full Text]

				J. W. Calvert and D. J. Lefer Myocardial protection by nitrite Cardiovasc Res, July 15, 2009; 83(2): 195 - 203. [Abstract] [Full Text] [PDF]

				J. W. Calvert, S. Gundewar, S. Jha, J. J.M. Greer, W. H. Bestermann, R. Tian, and D. J. Lefer Acute Metformin Therapy Confers Cardioprotection Against Myocardial Infarction Via AMPK-eNOS-Mediated Signaling Diabetes, March 1, 2008; 57(3): 696 - 705. [Abstract] [Full Text] [PDF]

				R. M. Mentzer Jr, M. S. Jahania, and R. D. Lasley Myocardial Protection Card. Surg. Adult, January 1, 2008; 3(2008): 443 - 464. [Full Text]

				N. S. Bryan, J. W. Calvert, J. W. Elrod, S. Gundewar, S. Y. Ji, and D. J. Lefer Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury PNAS, November 27, 2007; 104(48): 19144 - 19149. [Abstract] [Full Text] [PDF]

				M. C. Stuhlinger, E. Conci, B. J. Haubner, E.-M. Stocker, J. Schwaighofer, J. P. Cooke, P. S. Tsao, O. Pachinger, and B. Metzler Asymmetric Dimethyl L-Arginine (ADMA) is a critical regulator of myocardial reperfusion injury Cardiovasc Res, July 15, 2007; 75(2): 417 - 425. [Abstract] [Full Text] [PDF]

				Z.-Q. Zhao and J. Vinten-Johansen Postconditioning: Reduction of reperfusion-induced injury Cardiovasc Res, May 1, 2006; 70(2): 200 - 211. [Abstract] [Full Text] [PDF]

				D. R. Bell and K. Gochenaur Direct vasoactive and vasoprotective properties of anthocyanin-rich extracts J Appl Physiol, April 1, 2006; 100(4): 1164 - 1170. [Abstract] [Full Text] [PDF]

				D. Omiyi, R. J. Brue, P. Taormina II, M. Harvey, N. Atkinson, and L. H. Young Protein Kinase C {beta}II Peptide Inhibitor Exerts Cardioprotective Effects in Rat Cardiac Ischemia/Reperfusion Injury J. Pharmacol. Exp. Ther., August 1, 2005; 314(2): 542 - 551. [Abstract] [Full Text] [PDF]

				S. Das, A. Tosaki, D. Bagchi, N. Maulik, and D. K. Das Resveratrol-Mediated Activation of cAMP Response Element-Binding Protein through Adenosine A3 Receptor by Akt-Dependent and -Independent Pathways J. Pharmacol. Exp. Ther., August 1, 2005; 314(2): 762 - 769. [Abstract] [Full Text] [PDF]

				J Trevelyan, E W A Needham, A Morris, and R K Mattu Comparison of the effect of enalapril and losartan in conjunction with surgical coronary revascularisation versus revascularisation alone on systemic endothelial function Heart, August 1, 2005; 91(8): 1053 - 1057. [Abstract] [Full Text] [PDF]

				A. Phillipson, E. E. Peterman, P. Taormina Jr., M. Harvey, R. J. Brue, N. Atkinson, D. Omiyi, U. Chukwu, and L. H. Young Protein kinase C-{zeta} inhibition exerts cardioprotective effects in ischemia-reperfusion injury Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H898 - H907. [Abstract] [Full Text] [PDF]

				P. J. Kuhlencordt, E. Rosel, R. E. Gerszten, M. Morales-Ruiz, D. Dombkowski, W. J. Atkinson, F. Han, F. Preffer, A. Rosenzweig, W. C. Sessa, et al. Role of endothelial nitric oxide synthase in endothelial activation: insights from eNOS knockout endothelial cells Am J Physiol Cell Physiol, May 1, 2004; 286(5): C1195 - C1202. [Abstract] [Full Text] [PDF]

				H. Kin, Z.-Q. Zhao, H.-Y. Sun, N.-P. Wang, J. S. Corvera, M. E. Halkos, F. Kerendi, R. A. Guyton, and J. Vinten-Johansen Postconditioning attenuates myocardial ischemia-reperfusion injury by inhibiting events in the early minutes of reperfusion Cardiovasc Res, April 1, 2004; 62(1): 74 - 85. [Abstract] [Full Text] [PDF]

				R. Schulz, M. Kelm, and G. Heusch Nitric oxide in myocardial ischemia/reperfusion injury Cardiovasc Res, February 15, 2004; 61(3): 402 - 413. [Abstract] [Full Text] [PDF]

				J. Vinten-Johansen Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury Cardiovasc Res, February 15, 2004; 61(3): 481 - 497. [Abstract] [Full Text] [PDF]

				M. Galinanes and A. G Fowler Role of clinical pathologies in myocardial injury following ischaemia and reperfusion Cardiovasc Res, February 15, 2004; 61(3): 512 - 521. [Abstract] [Full Text] [PDF]

				J. Gianetti, P. Del Sarto, S. Bevilacqua, C. Vassalle, R. De Filippis, M. Kacila, P. A. Farneti, A. Clerico, M. Glauber, and A. Biagini Supplemental nitric oxide and its effect on myocardial injury and function in patients undergoing cardiac surgery with extracorporeal circulation J. Thorac. Cardiovasc. Surg., January 1, 2004; 127(1): 44 - 50. [Abstract] [Full Text] [PDF]

				Y. Hayashi, Y. Sawa, N. Fukuyama, Y. Miyamoto, T. Takahashi, H. Nakazawa, and H. Matsuda Leukocyte-depleted terminal blood cardioplegia provides superior myocardial protective effects in association with myocardium-derived nitric oxide and peroxynitrite production for patients undergoing prolonged aortic crossclamping for more than 120 minutes J. Thorac. Cardiovasc. Surg., December 1, 2003; 126(6): 1813 - 1821. [Abstract] [Full Text] [PDF]

				C. L. Speyer, T. A. Neff, R. L. Warner, R.-F. Guo, J. V. Sarma, N. C. Riedemann, M. E. Murphy, H. S. Murphy, and P. A. Ward Regulatory Effects of iNOS on Acute Lung Inflammatory Responses in Mice Am. J. Pathol., December 1, 2003; 163(6): 2319 - 2328. [Abstract] [Full Text]

				B. Y. Poon, E. Raharjo, K. D. Patel, S. Tavener, and P. Kubes Complexity of Inducible Nitric Oxide Synthase: Cellular Source Determines Benefit Versus Toxicity Circulation, September 2, 2003; 108(9): 1107 - 1112. [Abstract] [Full Text] [PDF]

				Z.-Q. Zhao, J. S. Corvera, M. E. Halkos, F. Kerendi, N.-P. Wang, R. A. Guyton, and J. Vinten-Johansen Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning Am J Physiol Heart Circ Physiol, August 1, 2003; 285(2): H579 - H588. [Abstract] [Full Text] [PDF]

				K. Laude, J. Favre, C. Thuillez, and V. Richard NO produced by endothelial NO synthase is a mediator of delayed preconditioning-induced endothelial protection Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H2053 - H2060. [Abstract] [Full Text] [PDF]

				R. J. Reiter and D.-X. Tan Melatonin: a novel protective agent against oxidative injury of the ischemic/reperfused heart Cardiovasc Res, April 1, 2003; 58(1): 10 - 19. [Abstract] [Full Text] [PDF]

				R. M. Mentzer Jr., M. S. Jahania, and R. D. Lasley Myocardial Protection Card. Surg. Adult, January 1, 2003; 2(2003): 413 - 438. [Full Text]

				D. R. Bell, K. E. Gochenaur, and J. Hecht O2--mediated impairment of coronary arterial relaxation is prevented by overnight treatment with 1 nM beta -estradiol J Appl Physiol, December 1, 2002; 93(6): 1952 - 1958. [Abstract] [Full Text] [PDF]

				S. P. Jones, M. F. Gibson, D. M. Rimmer III, T. M. Gibson, B. R. Sharp, and D. J. Lefer Direct vascular and cardioprotective effects of rosuvastatin, a new HMG-CoA reductase inhibitor J. Am. Coll. Cardiol., September 18, 2002; 40(6): 1172 - 1178. [Abstract] [Full Text] [PDF]

				H. Ogita, K. Node, H. Asanuma, S. Sanada, Y. Liao, S. Takashima, M. Asakura, H. Mori, Y. Shinozaki, M. Hori, et al. Amelioration of ischemia- and reperfusion-induced myocardial injury by the selective estrogen receptor modulator, raloxifene, in the canine heart J. Am. Coll. Cardiol., September 4, 2002; 40(5): 998 - 1005. [Abstract] [Full Text] [PDF]

				R. Hattori, H. Otani, N. Maulik, and D. K. Das Pharmacological preconditioning with resveratrol: role of nitric oxide Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H1988 - H1995. [Abstract] [Full Text] [PDF]

				G. Imamura, A. A. Bertelli, A. Bertelli, H. Otani, N. Maulik, and D. K. Das Pharmacological preconditioning with resveratrol: an insight with iNOS knockout mice Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H1996 - H2003. [Abstract] [Full Text] [PDF]

				G. Booth, T. J. Stalker, A. M. Lefer, and R. Scalia Mechanisms of Amelioration of Glucose-Induced Endothelial Dysfunction Following Inhibition of Protein Kinase C In Vivo Diabetes, May 1, 2002; 51(5): 1556 - 1564. [Abstract] [Full Text] [PDF]