Donate Help Contact The AHA Sign In Home
American Heart Association
Circulation Research
Search: search_blue_button Advanced Search
« Previous Article | Table of Contents | Next Article »
Circulation Research. 1988;62:191-195

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Edwards, B. S.
Right arrow Articles by Burnett, J. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Edwards, B. S.
Right arrow Articles by Burnett, J. C., Jr
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH

Circulation Research, Vol 62, 191-195, Copyright © 1988 by American Heart Association

ARTICLES

Atrial stretch, not pressure, is the principal determinant controlling the acute release of atrial natriuretic factor

BS Edwards, RS Zimmerman, TR Schwab, DM Heublein and JC Burnett Jr
Department of Internal Medicine, Mayo Medical School, Rochester, Minn. 55905.

The current studies were designed to investigate the mechanisms in the intact anesthetized dog that control the release of atrial natriuretic factor (ANF). In vitro, mechanical stretch of atrial tissue produces an increased release of ANF. In vivo, changes in atrial pressure correlate positively with circulating ANF levels. The present investigations used 6 open-chest anesthetized dogs to evaluate the role of atrial pressure versus atrial stretch, the latter determined by atrial transmural pressure, in the release of ANF. In a paired design, animals underwent cardiac tamponade followed by constriction of the aorta and pulmonary artery. Tamponade produces a balanced increase in intra-atrial and pericardial pressures. Thus, despite an elevated atrial pressure, there is no increase in transmural pressure producing atrial stretch. Great artery constriction increases intra-atrial but not pericardial pressure, resulting in an increase in atrial transmural pressure and atrial stretch. Cardiac tamponade increased right atrial pressure (0.8 +/- 0.3 to G.6 +/- 0.6 mm Hg, p less than 0.001) and pulmonary capillary wedge pressure (3.7 +/- 0.6 to 8.8 +/- 0.6 mm Hg, P less than 0.001). Constriction of the aorta and pulmonary artery also increased right atrial pressure (1.5 +/- 0.8 to 6.3 +/- 0.8 mm Hg, p less than 0.05) and pulmonary capillary wedge pressure (4.6 +/- 0.3 to 7.8 +/- 1.0 mm Hg, p less than 0.05). Atrial transmural pressure increased only during great artery constriction.(ABSTRACT TRUNCATED AT 250 WORDS)


This article has been cited by other articles:


Home page
 HypertensionHome page
G. Boerrigter, L. C. Costello-Boerrigter, A. Cataliotti, H. Lapp, J.-P. Stasch, and J. C. Burnett Jr
Targeting Heme-Oxidized Soluble Guanylate Cyclase in Experimental Heart Failure
Hypertension, May 1, 2007; 49(5): 1128 - 1133.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
L. R. Potter, S. Abbey-Hosch, and D. M. Dickey
Natriuretic Peptides, Their Receptors, and Cyclic Guanosine Monophosphate-Dependent Signaling Functions
Endocr. Rev., February 1, 2006; 27(1): 47 - 72.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart J SupplHome page
B. J. Gersh, T. S.M. Tsang, M. E. Barnes, and J. B. Seward
The changing epidemiology of non-valvular atrial fibrillation: the role of novel risk factors
Eur. Heart J. Suppl., May 1, 2005; 7(suppl_C): C5 - C11.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
W. E. Hopkins, Z. Chen, N. K. Fukagawa, C. Hall, H. J. Knot, and M. M. LeWinter
Increased Atrial and Brain Natriuretic Peptides in Adults With Cyanotic Congenital Heart Disease: Enhanced Understanding of the Relationship Between Hypoxia and Natriuretic Peptide Secretion
Circulation, June 15, 2004; 109(23): 2872 - 2877.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Heart FailHome page
A. Kjaer, J. Appel, P. Hildebrandt, and C. L. Petersen
Basal and exercise-induced neuroendocrine activation in patients with heart failure and in normal subjects
Eur J Heart Fail, January 1, 2004; 6(1): 29 - 39.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
S. I. McFarlane, N. Winer, and J. R. Sowers
Role of the Natriuretic Peptide System in Cardiorenal Protection
Arch Intern Med, December 8, 2003; 163(22): 2696 - 2704.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. M. Hamad, A. Clayton, B. Islam, and A. J. Knox
Guanylyl cyclases, nitric oxide, natriuretic peptides, and airway smooth muscle function
Am J Physiol Lung Cell Mol Physiol, November 1, 2003; 285(5): L973 - L983.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
M. Schmitt, A. J.M. Broadley, A. K. Nightingale, N. Payne, P. Gunaruwan, J. Taylor, L. Lee, J. Cockcroft, A. D. Struthers, and M. P. Frenneaux
Atrial Natriuretic Peptide Regulates Regional Vascular Volume and Venous Tone in Humans
Arterioscler Thromb Vasc Biol, October 1, 2003; 23(10): 1833 - 1838.
[Abstract] [Full Text] [PDF]

Home page
 Journal of Renin-Angiotensin-Aldosterone SystemHome page
K. H Chee, K. Amudha, N. A Hussain, H. K Haizal, A.-M. J Choy, and C. C Lang
Combination of drugs acting on the natriuretic system and the renin-angiotensin system in heart failure
Journal of Renin-Angiotensin-Aldosterone System, September 1, 2003; 4(3): 140 - 148.
[Abstract] [PDF]

Home page
 Eur J Heart FailHome page
D. Mariano-Goulart, M.-C. Eberle, V. Boudousq, A. Hejazi-Moughari, C. Piot, C. C. de Kerleau, R. Verdier, M.-L. Barge, F. Comte, N. Bressot, et al.
Major increase in brain natriuretic peptide indicates right ventricular systolic dysfunction in patients with heart failure
Eur J Heart Fail, August 1, 2003; 5(4): 481 - 488.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
T. Hakala, A. Hedman, A. Turpeinen, R. Kettunen, O. Vuolteenaho, and M. Hippelainen
Prediction of atrial fibrillation after coronary artery bypass grafting by measuring atrial peptide levels and preoperative atrial dimensions
Eur. J. Cardiothorac. Surg., December 1, 2002; 22(6): 939 - 943.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Heart FailHome page
B. A. Groenning, J. C. Nilsson, P. R. Hildebrandt, A. Kjaer, T. Fritz-Hansen, H. B.W. Larsson, and L. Sondergaard
Neurohumoral prediction of left-ventricular morphologic response to {beta}-blockade with metoprolol in chronic left-ventricular systolic heart failure
Eur J Heart Fail, October 1, 2002; 4(5): 635 - 646.
[Abstract] [Full Text] [PDF]

Home page
 Journal of Pharmacy PracticeHome page
M. A. Militello
Role of Nesiritide in Decompensated Heart Failure
Journal of Pharmacy Practice, August 1, 2002; 15(4): 326 - 333.
[Abstract] [PDF]

Home page
 ChestHome page
M. A. Zullo
Characteristics of the Acute Rise of Atrial Natriuretic Factor During Ventricular Pacing*
Chest, June 1, 2002; 121(6): 1942 - 1946.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Heart FailHome page
M. P. van den Berg, G. Tjeerdsma, P. J. de Kam, F. Boomsma, H. J.G.M. Crijns, and D. J. van Veldhuisen
Longstanding atrial fibrillation causes depletion of atrial natriuretic peptide in patients with advanced congestive heart failure
Eur J Heart Fail, June 1, 2002; 4(3): 255 - 262.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
K. Tayama, S. Takamori, M. Mitsuoka, A. Hayashi, K. Tamura, H. Mifune, and K. Shirouzu
Natriuretic peptides after pulmonary resection
Ann. Thorac. Surg., May 1, 2002; 73(5): 1582 - 1586.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. S. T. LEUNG and T. DOUGLAS BRADLEY
Sleep Apnea and Cardiovascular Disease
Am. J. Respir. Crit. Care Med., December 15, 2001; 164(12): 2147 - 2165.
[Full Text] [PDF]

Home page
 Eur J Heart FailHome page
B. A. Groenning, J. C. Nilsson, L. Sondergaard, A. Kjaer, H. B.W. Larsson, and P. R. Hildebrandt
Evaluation of impaired left ventricular ejection fraction and increased dimensions by multiple neurohumoral plasma concentrations
Eur J Heart Fail, December 1, 2001; 3(6): 699 - 708.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
Guidelines for the management of patients with atrial fibrillation. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines and Policy Conferences (Committee to develop guidelines for the management of patients with atrial fibrillation) developed in collaboration with the North American Society of Pacing and Electrophysiology
Eur. Heart J., October 2, 2001; 22(20): 1852 - 1923.
[PDF]

Home page
 J Am Coll CardiolHome page
R. Wiedemann, H. A. Ghofrani, N. Weissmann, R. Schermuly, K. Quanz, F. Grimminger, W. Seeger, and H. Olschewski
Atrial natriuretic peptide in severe primary and nonprimary pulmonary hypertension: Response to iloprost inhalation
J. Am. Coll. Cardiol., October 1, 2001; 38(4): 1130 - 1136.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
V. Fuster, L. E. Ryden, R. W. Asinger, D. S. Cannom, H. J. Crijns, R. L. Frye, J. L. Halperin, G. N. Kay, W. W. Klein, S. Levy, et al.
ACC/AHA/ESC guidelines for the management of patients with atrial fibrillation: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines and Policy Conferences (Committee to Develop Guidelines for the Management of Patients With Atrial Fibrillation) Developed in Collaboration With the North American Society of Pacing and Electrophysiology
J. Am. Coll. Cardiol., October 1, 2001; 38(4): 1266 - 1266.
[Full Text] [PDF]

Home page
 Cardiovasc ResHome page
B. Geny, R. Richard, B. Mettauer, J. Lonsdorfer, and F. Piquard
Cardiac natriuretic peptides during exercise and training after heart transplantation
Cardiovasc Res, August 15, 2001; 51(3): 521 - 528.
[Full Text] [PDF]

Home page
 Cardiovasc ResHome page
A. Luchner, F. Muders, O. Dietl, E. Friedrich, F. Blumberg, A.A. Protter, G.A.J. Riegger, and D. Elsner
Differential expression of cardiac ANP and BNP in a rabbit model of progressive left ventricular dysfunction
Cardiovasc Res, August 15, 2001; 51(3): 601 - 607.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
C Briguori, S Betocchi, F Manganelli, B Gigante, M.A Losi, Q Ciampi, R Gottilla, A Violante, C.G Tocchetti, M Volpe, et al.
Determinants and clinical significance of natriuretic peptides and hypertrophic cardiomyopathy
Eur. Heart J., August 1, 2001; 22(15): 1328 - 1336.
[Abstract] [PDF]

Home page
 ChestHome page
Y. Ootaki, M. Okada, T. Tsukube, and Y. Okita
The Effect of Cardiomyoplasty on Left Atrial Function in Experimental Canine Models
Chest, May 1, 2001; 119(5): 1526 - 1532.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
T. Walther, H. Stepan, and R. Faber
Dual natriuretic peptide response to volume load in the fetal circulation
Cardiovasc Res, March 1, 2001; 49(4): 817 - 819.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Heart FailHome page
A. Luchner, D. D. Borgeson, J. A. Grantham, E. Friedrich, G. A.J. Riegger, J. C. Burnett Jr, and M. M. Redfield
Relationship between left ventricular wall stress and ANP gene expression during the evolution of rapid ventricular pacing-induced heart failure in the dog
Eur J Heart Fail, December 1, 2000; 2(4): 379 - 386.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
O. Lisy, M. M. Redfield, S. Jovanovic, M. Jougasaki, A. Jovanovic, H. Leskinen, A. Terzic, and J. C. Burnett Jr
Mechanical Unloading Versus Neurohumoral Stimulation on Myocardial Structure and Endocrine Function In Vivo
Circulation, July 18, 2000; 102(3): 338 - 343.
[Abstract] [Full Text] [PDF]

Home page
 Biol Res NursHome page
S. D. Kim and M. R. Piano
The Natriuretic Peptides: Physiology and Role in Left-Ventricular Dysfunction
Biol Res Nurs, July 1, 2000; 2(1): 15 - 29.
[Abstract] [PDF]

Home page
 J Am Coll CardiolHome page
A. Rossi, M. Enriquez-Sarano, J. C. Burnett Jr., A. Lerman, M. D. Abel, and J. B. Seward
Natriuretic peptide levels in atrial fibrillation: A prospective hormonal and Doppler-echocardiographic study
J. Am. Coll. Cardiol., April 1, 2000; 35(5): 1256 - 1262.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
G McDowell, M Cave, A Bainbridge, M Danton, C Shaw, K.D Buchanan, J Wallwork, S Large, and D.P Nicholls
Is the secretion of atrial natriuretic peptide in man under neural control?
Eur. Heart J., March 2, 2000; 21(6): 498 - 503.
[Abstract] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. M. Hamad, S. R. Johnson, and A. J. Knox
Antiproliferative effects of NO and ANP in cultured human airway smooth muscle
Am J Physiol Lung Cell Mol Physiol, November 1, 1999; 277(5): L910 - L918.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
P. Tavi, M. Laine, S. Voutilainen, P. Lehenkari, O. Vuolteenaho, H. Ruskoaho, and M. Weckstrom
Potentiation of stretch-induced atrial natriuretic peptide secretion by intracellular acidosis
Am J Physiol Heart Circ Physiol, July 1, 1999; 277(1): H405 - H412.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
R. Willenbrock, M. Scheuermann, G. Thibault, Markus Haass, K. Hohnel, J. Bohlender, F. C. Luft, and Rainer Dietz
Angiotensin inhibition and atrial natriuretic peptide release after acute volume expansion in rats with aortocaval shunt
Cardiovasc Res, June 1, 1999; 42(3): 733 - 742.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
F. Valsson, S. Lundin, K. Kirno, T. Hedner, E. Houltz, Y. Saito, and S.-E. Ricksten
Atrial Natriuretic Peptide Attenuates Pacing-Induced Myocardial Ischemia During General Anesthesia in Patients with Coronary Artery Disease
Anesth. Analg., February 1, 1999; 88(2): 279 - 279.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. Geny, A. Charloux, E. Lampert, J. Lonsdorfer, P. Haberey, and F. Piquard
Enhanced brain natriuretic peptide response to peak exercise in heart transplant recipients
J Appl Physiol, December 1, 1998; 85(6): 2270 - 2276.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
K. Doyama, M. Fukumoto, G. Takemura, M. Tanaka, T. Oda, K. Hasegawa, T. Inada, S. Ohtani, T. Fujiwara, H. Itoh, et al.
Expression and distribution of brain natriuretic peptide in human right atria
J. Am. Coll. Cardiol., December 1, 1998; 32(7): 1832 - 1838.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
M. Bogdan, M. Humbert, J. Francoual, C. Claise, P. Duroux, G. Simonneau, and A. Lindenbaum
Urinary cGMP concentrations in severe primary pulmonary hypertension
Thorax, December 1, 1998; 53(12): 1059 - 1062.
[Abstract] [Full Text]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
K.-B. Kim, C.-H. Lee, C.-H. Kim, Y.-J. Cha, S. :, and J. L. Cox
Effect of the Cox maze procedure on the secretion of atrial natriuretic peptide
J. Thorac. Cardiovasc. Surg., January 1, 1998; 115(1): 139 - 147.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
W. E. Hopkins and C. Hall
Paradoxical Relationship Between N-Terminal Proatrial Natriuretic Peptide and Filling Pressure in Adults With Cyanotic Congenital Heart Disease
Circulation, October 7, 1997; 96(7): 2215 - 2220.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
H. Leskinen, O. Vuolteenaho, M. Toth, and H. Ruskoaho
Atrial Natriuretic Peptide (ANP) Inhibits Its Own Secretion via ANPA Receptors: Altered Effect in Experimental Hypertension
Endocrinology, May 1, 1997; 138(5): 1893 - 1902.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
H. Leskinen, O. Vuolteenaho, and H. Ruskoaho
Combined Inhibition of Endothelin and Angiotensin II Receptors Blocks Volume Load–Induced Cardiac Hormone Release
Circ. Res., January 1, 1997; 80(1): 114 - 123.
[Abstract] [Full Text]

Home page
 CirculationHome page
E. J. Eichhorn and M. R. Bristow
Medical Therapy Can Improve the Biological Properties of the Chronically Failing Heart: A New Era in the Treatment of Heart Failure
Circulation, November 1, 1996; 94(9): 2285 - 2296.
[Abstract] [Full Text]

Home page
 CirculationHome page
R. O. Bonow
New Insights Into the Cardiac Natriuretic Peptides
Circulation, June 1, 1996; 93(11): 1946 - 1950.
[Full Text]


Circulation Research Home | Subscriptions | Archives | Feedback | Authors | Help | AHA Journals Home | Search
Copyright © 1988 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited.