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Circulation Research. 1987;61:555-559

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Circulation Research, Vol 61, 555-559, Copyright © 1987 by American Heart Association

ARTICLES

Attenuation of reflex forearm vasoconstriction by alpha-human atrial natriuretic peptide in men

A Takeshita, T Imaizumi, N Nakamura, H Higashi, T Sasaki, M Nakamura, K Kangawa and H Matsuo
Research Institute of Angiocardiology, Kyushu University, Faculty of Medicine, Fukuoka, Japan.

This study examined whether atrial natriuretic peptide (ANP) modulates reflex forearm vasoconstriction in humans. Synthetic alpha-human ANP (alpha-hANP) was infused at a rate of 0.03 microgram/kg/min in 8 healthy men (mean age 23 +/- 0.7 years, mean +/- SEM). The alpha-hANP decreased systolic blood pressure and central venous pressure (CVP) but did not significantly alter resting heart rate and forearm vascular resistance (FVR). The magnitudes of reflex increases in FVR during lower body negative pressure (LBNP) at -110, -20, and -40 mm Hg were less during infusion of alpha-ANP than those magnitudes during infusion of saline solution. The slope of the regression line relating changes in CVP and those in FVR was less during infusion of alpha-hANP than the slope during infusion of saline solution. Forearm vascular responses to intra-arterial infusion of norepinephrine at doses of 100, 200, and 500 ng/min did not significantly differ during infusion of alpha-hANP and saline solution. These results suggest that alpha-hANP attenuates cardiopulmonary baroreflex control of FVR in normal men.


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