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Circulation Research. 1987;61:70-76

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Circulation Research, Vol 61, 70-76, Copyright © 1987 by American Heart Association

ARTICLES

Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure

JK Gwathmey, L Copelas, R MacKinnon, FJ Schoen, MD Feldman, W Grossman and JP Morgan

Intracellular Ca2+ release and reuptake are essential for contraction and relaxation of normal heart muscle. Intracellular Ca2+ transients were recorded with aequorin during isometric contraction of myocardium from patients with end-stage heart failure. In contrast to controls, contractions and Ca2+ transients of muscles from failing hearts were markedly prolonged, and the Ca2+ transients exhibited 2 distinct components. Muscles from failing hearts showed a diminished capacity to restore low resting Ca2+ levels during diastole. These experiments provide the first direct evidence from actively contracting human myocardium that intracellular Ca2+ handling is abnormal and may cause systolic and diastolic dysfunction in heart failure.


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Cardiovasc Res, April 1, 2001; 50(1): 10 - 23.
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 Circ. Res.Home page
M. Periasamy
Adenoviral-Mediated SERCA Gene Transfer Into Cardiac Myocytes : How Much Is Too Much?
Circ. Res., March 2, 2001; 88(4): 373 - 375.
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 Circ. Res.Home page
J. M. O'Donnell, C. M. Sumbilla, H. Ma, I. K. G. Farrance, M. Cavagna, M. G. Klein, and G. Inesi
Tight Control of Exogenous SERCA Expression Is Required to Obtain Acceleration of Calcium Transients With Minimal Cytotoxic Effects in Cardiac Myocytes
Circ. Res., March 2, 2001; 88(4): 415 - 421.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Heart Circ. Physiol.Home page
A. C. Nicolosi, C. S. Kwok, S. J. Contney, G. N. Olinger, and Z. J. Bosnjak
Gadolinium prevents stretch-mediated contractile dysfunction in isolated papillary muscles
Am J Physiol Heart Circ Physiol, March 1, 2001; 280(3): H1122 - H1128.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Heart Circ. Physiol.Home page
K. L. Golden, J. Ren, J. O'Connor, A. Dean, S. E. DiCarlo, and J. D. Marsh
In vivo regulation of Na/Ca exchanger expression by adrenergic effectors
Am J Physiol Heart Circ Physiol, March 1, 2001; 280(3): H1376 - H1382.
[Abstract] [Full Text] [PDF]

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 Ann. Thorac. Surg.Home page
G. S. Kumpati, P. M. McCarthy, and K. J. Hoercher
Left ventricular assist device bridge to recovery: a review of the current status
Ann. Thorac. Surg., March 1, 2001; 71 (2007): S103 - S108.
[Abstract] [Full Text] [PDF]

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 JGPHome page
C. R. Weber, K. S. Ginsburg, K. D. Philipson, T. R. Shannon, and D. M. Bers
Allosteric Regulation of Na/Ca Exchange Current by Cytosolic Ca in Intact Cardiac Myocytes
J. Gen. Physiol., February 1, 2001; 117(2): 119 - 132.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Heart Circ. Physiol.Home page
G. A. MacGowan, C. Du, D. B. Cowan, C. Stamm, F. X. McGowan, R. J. Solaro, A. P. Koretsky, and P. J. Del Nido
Ischemic dysfunction in transgenic mice expressing troponin I lacking protein kinase C phosphorylation sites
Am J Physiol Heart Circ Physiol, February 1, 2001; 280(2): H835 - H843.
[Abstract] [Full Text] [PDF]

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 Cardiovasc ResHome page
A Baartscheer
Adenovirus gene transfer of SERCA in heart failure. A promising therapeutic approach ?
Cardiovasc Res, February 1, 2001; 49(2): 249 - 252.
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 CirculationHome page
J. N. Muth, I. Bodi, W. Lewis, G. Varadi, and A. Schwartz
A Ca2+-Dependent Transgenic Model of Cardiac Hypertrophy : A Role for Protein Kinase C{{alpha}}
Circulation, January 2, 2001; 103(1): 140 - 147.
[Abstract] [Full Text] [PDF]

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 Cardiovasc ResHome page
C. M.N. Terracciano, K. D. Philipson, and K. T. MacLeod
Overexpression of the Na+/Ca2+ exchanger and inhibition of the sarcoplasmic reticulum Ca2+-ATPase in ventricular myocytes from transgenic mice
Cardiovasc Res, January 1, 2001; 49(1): 38 - 47.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Heart Circ. Physiol.Home page
T. G. Hampton, J.-F. Wang, J. DeAngelis, I. Amende, K. D. Philipson, and J. P. Morgan
Enhanced gene expression of Na+/Ca2+ exchanger attenuates ischemic and hypoxic contractile dysfunction
Am J Physiol Heart Circ Physiol, December 1, 2000; 279(6): H2846 - H2854.
[Abstract] [Full Text] [PDF]

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 Circ. Res.Home page
K. R. Sipido
Local Ca2+ Release in Heart Failure : Timing Is Important
Circ. Res., November 24, 2000; 87(11): 966 - 968.
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 J. Physiol.Home page
M. Cavagna, J M. O'Donnell, C. Sumbilla, G. Inesi, and M. G Klein
Exogenous Ca2+-ATPase isoform effects on Ca2+ transients of embryonic chicken and neonatal rat cardiac myocytes
J. Physiol., October 1, 2000; 528(1): 53 - 63.
[Abstract] [Full Text] [PDF]

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 Circ. Res.Home page
W. H. Barry
Na+-Ca2+ Exchange in Failing Myocardium : Friend or Foe?
Circ. Res., September 29, 2000; 87(7): 529 - 531.
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 CirculationHome page
M. Koide, M. Hamawaki, T. Narishige, H. Sato, S. Nemoto, G. DeFreyte, M. R. Zile, G. Cooper IV, and B. A. Carabello
Microtubule Depolymerization Normalizes In Vivo Myocardial Contractile Function in Dogs With Pressure-Overload Left Ventricular Hypertrophy
Circulation, August 29, 2000; 102(9): 1045 - 1052.
[Abstract] [Full Text] [PDF]

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 J. Pharmacol. Exp. Ther.Home page
B. Linck, P. Bokník, S. Huke, U. Kirchhefer, J. Knapp, H. Lüss, F. U. Müller, J. Neumann, Z. Tanriseven, U. Vahlensieck, et al.
Functional Properties of Transgenic Mouse Hearts Overexpressing Both Calsequestrin and the Na+-Ca2+ Exchanger
J. Pharmacol. Exp. Ther., August 1, 2000; 294(2): 648 - 657.
[Abstract] [Full Text]

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 Am. J. Physiol. Heart Circ. Physiol.Home page
L. Sen, G. Cui, G. C. Fonarow, and H. Laks
Differences in mechanisms of SR dysfunction in ischemic vs. idiopathic dilated cardiomyopathy
Am J Physiol Heart Circ Physiol, August 1, 2000; 279(2): H709 - H718.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Heart Circ. Physiol.Home page
J. A. Wasserstrom, E. Holt, I. Sjaastad, P. K. Lunde, A. Odegaard, and O. M. Sejersted
Altered E-C coupling in rat ventricular myocytes from failing hearts 6 wk after MI
Am J Physiol Heart Circ Physiol, August 1, 2000; 279(2): H798 - H807.
[Abstract] [Full Text] [PDF]

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 Cardiovasc ResHome page
S. Barrere-Lemaire, C. Piot, F. Leclercq, J. Nargeot, and S. Richard
Facilitation of L-type calcium currents by diastolic depolarization in cardiac cells: impairment in heart failure
Cardiovasc Res, August 1, 2000; 47(2): 336 - 349.
[Abstract] [Full Text] [PDF]

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 J Am Coll CardiolHome page
C. Piper, J. Bilger, E.-M. Henrichs, H.-P. Schultheiss, D. Horstkotte, and A. Doerner
Is myocardial Na+/Ca2+ exchanger transcription a marker for different stages of myocardial dysfunction? Quantitative polymerase chain reaction of the messenger RNA in endomyocardial biopsies of patients with heart failure
J. Am. Coll. Cardiol., July 1, 2000; 36(1): 233 - 241.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Heart Circ. Physiol.Home page
S. Mitarai, T. D. Reed, and A. Yatani
Changes in ionic currents and beta -adrenergic receptor signaling in hypertrophied myocytes overexpressing Galpha q
Am J Physiol Heart Circ Physiol, July 1, 2000; 279(1): H139 - H148.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Heart Circ. Physiol.Home page
G. Munch, B. Bolck, K. Brixius, H. Reuter, U. Mehlhorn, W. Bloch, and R. H. G. Schwinger
SERCA2a activity correlates with the force-frequency relationship in human myocardium
Am J Physiol Heart Circ Physiol, June 1, 2000; 278(6): H1924 - H1932.
[Abstract] [Full Text] [PDF]

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 Circ. Res.Home page
T. Kaneko, H. Tanaka, M. Oyamada, S. Kawata, and T. Takamatsu
Three Distinct Types of Ca2+ Waves in Langendorff-Perfused Rat Heart Revealed by Real-Time Confocal Microscopy
Circ. Res., May 26, 2000; 86(10): 1093 - 1099.
[Abstract] [Full Text] [PDF]

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 CirculationHome page
R. J. Hajjar, R. H.G. Schwinger, U. Schmidt, C. S. Kim, D. Lebeche, A. A. Doye, and J. K. Gwathmey
Myofilament Calcium Regulation in Human Myocardium
Circulation, April 11, 2000; 101(14): 1679 - 1685.
[Abstract] [Full Text] [PDF]

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 Circ. Res.Home page
R. J. Hajjar, F. del Monte, T. Matsui, and A. Rosenzweig
Prospects for Gene Therapy for Heart Failure
Circ. Res., March 31, 2000; 86(6): 616 - 621.
[Abstract] [Full Text] [PDF]

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 Cardiovasc ResHome page
R. G Matteo and C. S. Moravec
Immunolocalization of annexins IV, V and VI in the failing and non-failing human heart
Cardiovasc Res, March 1, 2000; 45(4): 961 - 970.
[Abstract] [Full Text] [PDF]

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 J. Thorac. Cardiovasc. Surg.Home page
C. A. Walker, F. A. Crawford Jr, and F. G. Spinale
MYOCYTE CONTRACTILE DYSFUNCTION WITH HYPERTROPHY AND FAILURE: RELEVANCE TO CARDIAC SURGERY
J. Thorac. Cardiovasc. Surg., February 1, 2000; 119(2): 388 - 400.
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 Proc. Natl. Acad. Sci. USAHome page
M. I. Miyamoto, F. del Monte, U. Schmidt, T. S. DiSalvo, Z. B. Kang, T. Matsui, J. L. Guerrero, J. K. Gwathmey, A. Rosenzweig, and R. J. Hajjar
Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure
PNAS, January 18, 2000; 97(2): 793 - 798.
[Abstract] [Full Text] [PDF]

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 Cardiovasc ResHome page
M.A. McIntosh, S.M. Cobbe, and G.L. Smith
Heterogeneous changes in action potential and intracellular Ca2+ in left ventricular myocyte sub-types from rabbits with heart failure
Cardiovasc Res, January 14, 2000; 45(2): 397 - 409.
[Abstract] [Full Text] [PDF]

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 Cardiovasc ResHome page
U Ravens and D Dobrev
Regulation of sarcoplasmic reticulum Ca2+-ATPase and phospholamban in the failing and nonfailing heart
Cardiovasc Res, January 1, 2000; 45(1): 245 - 252.
[Full Text] [PDF]

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 CirculationHome page
W. H. Barry
Molecular Inotropy : A Future Approach to the Treatment of Heart Failure?
Circulation, December 7, 1999; 100(23): 2303 - 2304.
[Full Text] [PDF]


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