Circulation Research, Vol 58, 427-444, Copyright © 1986 by American Heart Association

ARTICLES

Replication of smooth muscle cells in vascular disease

SM Schwartz, GR Campbell and JH Campbell

Smooth muscle proliferation has been recognized as central to the pathology of both major forms of vascular disease: atherosclerosis and hypertension. Recent advances in our knowledge of mechanisms of control of proliferation suggest that events occurring in adult animals may recapitulate portions of the developmental biology of the smooth muscle cell. This review attempts to consider the current state of knowledge of the mechanisms controlling smooth muscle proliferation in these two diseases, to put that knowledge into the context of what is known about smooth muscle biology, and to offer two hypotheses on the possible roles of smooth muscle developmental biology in manifestations of atherosclerosis and hypertension in adult humans.

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				C. Bauters, F. Marotte, M. Hamon, P. Oliviero, F. Farhadian, V. Robert, J. L. Samuel, and L. Rappaport Accumulation of Fetal Fibronectin mRNAs After Balloon Denudation of Rabbit Arteries Circulation, August 15, 1995; 92(4): 904 - 911. [Abstract] [Full Text]

				L. M. Shackelton, D. M. Mann, and A. J. T. Millis Identification of a 38-kDa Heparin-binding Glycoprotein (gp38k) in Differentiating Vascular Smooth Muscle Cells as a Member of a Group of Proteins Associated with Tissue Remodeling J. Biol. Chem., June 2, 1995; 270(22): 13076 - 13083. [Abstract] [Full Text] [PDF]

				J. Solway, J. Seltzer, F. F. Samaha, S. Kim, L. E. Alger, Q. Niu, E. E. Morrisey, H. S. Ip, and M. S. Parmacek Structure and Expression of a Smooth Muscle Cell-specific Gene, SM22[IMAGE] J. Biol. Chem., June 2, 1995; 270(22): 13460 - 13469. [Abstract] [Full Text] [PDF]

				D. A. Linseman, C. W. Benjamin, and D. A. Jones Convergence of Angiotensin II and Platelet-derived Growth Factor Receptor Signaling Cascades in Vascular Smooth Muscle Cells J. Biol. Chem., May 26, 1995; 270(21): 12563 - 12568. [Abstract] [Full Text] [PDF]

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				L Wilson, M. Carrier, and S Kellie pp125FAK tyrosine kinase activity is not required for the assembly of F-actin stress fibres and focal adhesions in cultured mouse aortic smooth muscle cells J. Cell Sci., January 6, 1995; 108(6): 2381 - 2391. [Abstract] [PDF]

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