Circulation Research, Vol 58, 193-201, Copyright © 1986 by American Heart Association

ARTICLES

Regulation of adenosine formation by the heart

HV Sparks Jr and H Bardenheuer

We think that the available data on adenosine formation suggest the two signals are responsible for adenosine release from cardiac myocytes: (1) the ratio of oxygen supply to demand and (2) agonist-triggered release of extracellular adenine nucleotides. We do not believe that the available data support the oxygen consumption hypothesis. The few studies which allow us to judge the relative importance of these two signals suggest that both hypoxia and sympathetic nerve stimulation release adenosine primarily by decreasing O2 supply:demand. Agonist triggered nucleotide release may be quantitatively important in situations in which decreased O2 supply/demand cannot explain increased release, i.e., isoproterenol and acetylcholine administration.

This article has been cited by other articles:

				D. J. Duncker and R. J. Bache Regulation of Coronary Blood Flow During Exercise Physiol Rev, July 1, 2008; 88(3): 1009 - 1086. [Abstract] [Full Text] [PDF]

				D. J. Duncker and D. Merkus Exercise hyperaemia in the heart: the search for the dilator mechanism J. Physiol., September 15, 2007; 583(3): 847 - 854. [Abstract] [Full Text] [PDF]

				K. Yuan, C. Cao, J. H. Han, S. Z. Kim, and S. H. Kim Adenosine-Stimulated Atrial Natriuretic Peptide Release Through A1 Receptor Subtype Hypertension, December 1, 2005; 46(6): 1381 - 1387. [Abstract] [Full Text] [PDF]

				T. H. Adair Growth regulation of the vascular system: an emerging role for adenosine Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2005; 289(2): R283 - R296. [Abstract] [Full Text] [PDF]

				A. K. Dutta, R. Z. Sabirov, H. Uramoto, and Y. Okada Role of ATP-conductive anion channel in ATP release from neonatal rat cardiomyocytes in ischaemic or hypoxic conditions J. Physiol., September 15, 2004; 559(3): 799 - 812. [Abstract] [Full Text] [PDF]

				Y. Chen and R. J. Bache Adenosine: A Modulator of the Cardiac Response to Stress Circ. Res., October 17, 2003; 93(8): 691 - 693. [Full Text] [PDF]

				D. Striimper, M. Durieux, and P. Roekaerts Endothelial and Microvascular Function Seminars in Cardiothoracic and Vascular Anesthesia, September 1, 2003; 7(3): 225 - 238. [Abstract] [PDF]

				T. Obata, H. Yonemochi, and M. Arita Norepinephrine Evoked by Potassium Depolarization Increases Interstitial Adenosine Concentration via Activation of ecto-5'-Nucleotidase in Rat Hearts J. Pharmacol. Exp. Ther., May 1, 2003; 305(2): 719 - 724. [Abstract] [Full Text] [PDF]

				T. Obata, S. Kubota, and Y. Yamanaka Histamine Increases Interstitial Adenosine Concentration via Activation of Ecto-5'-nucleotidase in Rat Hearts in Vivo J. Pharmacol. Exp. Ther., July 1, 2001; 298(1): 71 - 76. [Abstract] [Full Text]

				R Tabibiazar and S.G Rockson Angiogenesis and the ischaemic heart Eur. Heart J., June 1, 2001; 22(11): 903 - 918. [PDF]

				J.-W. Gu, B. R. Ito, A. Sartin, N. Frascogna, M. Moore, and T. H. Adair Inhibition of adenosine kinase induces expression of VEGF mRNA and protein in myocardial myoblasts Am J Physiol Heart Circ Physiol, November 1, 2000; 279(5): H2116 - H2123. [Abstract] [Full Text] [PDF]

				J. T. Barron and L. Gu Energetic effects of adenosine on vascular smooth muscle Am J Physiol Heart Circ Physiol, January 1, 2000; 278(1): H26 - H32. [Abstract] [Full Text] [PDF]

				A. Nishiyama, A. Miyatake, Y. Aki, T. Fukui, M. Rahman, S. Kimura, and Y. Abe Adenosine A1 Receptor Antagonist KW-3902 Prevents Hypoxia-Induced Renal Vasoconstriction J. Pharmacol. Exp. Ther., December 1, 1999; 291(3): 988 - 993. [Abstract] [Full Text]

				K. N. Richmond, J. D. Tune, M. W. Gorman, and E. O. Feigl Role of K+ATP channels in local metabolic coronary vasodilation Am J Physiol Heart Circ Physiol, December 1, 1999; 277(6): H2115 - H2123. [Abstract] [Full Text] [PDF]

				D. J. Duncker, R. Stubenitsky, and P. D. Verdouw Role of adenosine in the regulation of coronary blood flow in swine at rest and during treadmill exercise Am J Physiol Heart Circ Physiol, November 1, 1998; 275(5): H1663 - H1672. [Abstract] [Full Text] [PDF]

				R. Schulz, H. Post, C. Vahlhaus, and G. Heusch Ischemic Preconditioning in Pigs: A Graded Phenomenon : Its Relation to Adenosine and Bradykinin Circulation, September 8, 1998; 98(10): 1022 - 1029. [Abstract] [Full Text] [PDF]

				E. Gao, D. L. Snyder, J. Roberts, E. Friedman, G. Cai, A. Pelleg, and J. Horwitz Age-Related Decline in Beta Adrenergic and Adenosine A1 Receptor Function in the Heart Are Attenuated by Dietary Restriction J. Pharmacol. Exp. Ther., April 1, 1998; 285(1): 186 - 192. [Abstract] [Full Text]

				R. W. Brownsey, A. N. Boone, and M. F. Allard Actions of insulin on the mammalian heart: metabolism, pathology and biochemical mechanisms Cardiovasc Res, April 1, 1997; 34(1): 3 - 24. [Full Text] [PDF]

				W. Schaper and W. D. Ito Molecular Mechanisms of Coronary Collateral Vessel Growth Circ. Res., November 1, 1996; 79(5): 911 - 919. [Full Text]

				S. A. Rivkees, M. E. Lasbury, and H. Barbhaiya Identification of Domains of the Human A(1) Adenosine Receptor That Are Important for Binding Receptor Subtype-selective Ligands Using Chimeric A(1)/A[IMAGE] Adenosine Receptors J. Biol. Chem., September 1, 1995; 270(35): 20485 - 20490. [Abstract] [Full Text] [PDF]

				T. Mizumura, K. Nithipatikom, and G. J. Gross Bimakalim, an ATP-Sensitive Potassium Channel Opener, Mimics the Effects of Ischemic Preconditioning to Reduce Infarct Size, Adenosine Release, and Neutrophil Function in Dogs Circulation, September 1, 1995; 92(5): 1236 - 1245. [Abstract] [Full Text]

				E. A. Bukhari, I. B. Krukenkamp, P. G. Burns, G. R. Gaudette, J. J. Schulman, M. R. Al-Fagih, and S. Levitsky Does Aprotinin Increase the Myocardial Damage in the Setting of Ischemia and Preconditioning? Ann. Thorac. Surg., August 1, 1995; 60(2): 307 - 310. [Abstract] [Full Text]

				M. Kitakaze, M. Hori, T. Morioka, T. Minamino, S. Takashima, Y. Okazaki, K. Node, K. Komamura, K. Iwakura, T. Itoh, et al. {alpha}1-Adrenoceptor Activation Increases Ecto-5'-Nucleotidase Activity and Adenosine Release in Rat Cardiomyocytes by Activating Protein Kinase C Circulation, April 15, 1995; 91(8): 2226 - 2234. [Abstract] [Full Text]

				G. L. Dattilo, C. E. Eiriksson Jr, and R. E. Vestal Increased Ventricular Response Rate During Exercise in Patients With Atrial Fibrillation Treated With Theophylline Arch Intern Med, April 1, 1992; 152(4): 797 - 803. [Abstract] [PDF]

				G. A. Beller Pharmacologic Stress Imaging JAMA, February 6, 1991; 265(5): 633 - 638. [Abstract] [PDF]