Donate Help Contact The AHA Sign In Home
American Heart Association
Circulation Research
Search: search_blue_button Advanced Search
« Previous Article | Table of Contents | Next Article »
Circulation Research. 1985;57:84-95

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pfeffer, J. M.
Right arrow Articles by Braunwald, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pfeffer, J. M.
Right arrow Articles by Braunwald, E.

Circulation Research, Vol 57, 84-95, Copyright © 1985 by American Heart Association

ARTICLES

Influence of chronic captopril therapy on the infarcted left ventricle of the rat

JM Pfeffer, MA Pfeffer and E Braunwald

To determine whether the relationship between infarct size and ventricular performance, volume, and compliance could be altered favorably, captopril was administered to rats for 3 months following coronary artery ligation. Baseline left and right ventricular and systemic arterial pressures and aortic blood flow, and maximal stroke volume and cardiac indices attained during a volume loading, were measured. Passive pressure-volume relations of the left ventricle were determined, and the slopes of segments of this relation were analyzed to characterize ventricular chamber stiffness. In untreated rats, left ventricular end-diastolic pressure progressively rose (from 5-28 mm Hg) as a function of infarct size, whereas, in captopril-treated rats, filling pressure remained within normal limits (5 +/- 1 mm Hg) in all but those with extensive infarcts. Chronic captopril therapy reduced baseline mean arterial pressure and total peripheral resistance, yet maintained cardiac and stroke outputs in rats both with and without infarcts. In untreated rats, maximal pumping ability progressively declined with increasing infarct size, whereas, in captopril-treated rats, peak stroke volume index remained within normal limits in all but those with extensive infarcts. The in vitro left ventricular volumes of captopril-treated rats were significantly less than those of untreated rats. The maintenance of forward output from a lesser dilated left ventricle yielded an index of ejection fraction for treated rats with moderate and large infarcts that was significantly elevated compared with that of untreated rats with infarcts of comparable size. Left ventricular chamber stiffness, which fell as infarct size increased in untreated rats, was normalized by chronic captopril therapy. Thus, captopril attenuated the left ventricular remodeling (dilation) and deterioration in performance that were observed in rats with chronic myocardial infarction.


This article has been cited by other articles:


Home page
 Eur J Heart FailHome page
G.-Y. Song, Y.-J. Wu, Y.-J. Yang, J.-J. Li, H.-L. Zhang, H.-J. Pei, Z.-Y. Zhao, Z.-H. Zeng, and R.-T. Hui
The accelerated post-infarction progression of cardiac remodelling is associated with genetic changes in an untreated streptozotocin-induced diabetic rat model
Eur J Heart Fail, October 1, 2009; 11(10): 911 - 921.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
E. Braunwald
Adventures in Cardiovascular Research
Circulation, July 14, 2009; 120(2): 170 - 180.
[Abstract] [Full Text] [PDF]

Home page
 Circ Heart FailHome page
R. D. Patten and M. R. Hall-Porter
Small Animal Models of Heart Failure: Development of Novel Therapies, Past and Present
Circ Heart Fail, March 1, 2009; 2(2): 138 - 144.
[Full Text] [PDF]

Home page
 Cardiovasc ResHome page
M. Hori and K. Nishida
Oxidative stress and left ventricular remodelling after myocardial infarction
Cardiovasc Res, February 15, 2009; 81(3): 457 - 464.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
S. W.M. van den Borne, S. Isobe, J. W. Verjans, A. Petrov, D. Lovhaug, P. Li, H. R. Zandbergen, Y. Ni, P. Frederik, J. Zhou, et al.
Molecular Imaging of Interstitial Alterations in Remodeling Myocardium After Myocardial Infarction
J. Am. Coll. Cardiol., December 9, 2008; 52(24): 2017 - 2028.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
M. Tamamori-Adachi, H. Takagi, K. Hashimoto, K. Goto, T. Hidaka, U. Koshimizu, K. Yamada, I. Goto, Y. Maejima, M. Isobe, et al.
Cardiomyocyte proliferation and protection against post-myocardial infarction heart failure by cyclin D1 and Skp2 ubiquitin ligase
Cardiovasc Res, November 1, 2008; 80(2): 181 - 190.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
K. A. Martin and J. Hwa
Shp Shape: FAKs About Hypertrophy
Circ. Res., October 10, 2008; 103(8): 776 - 778.
[Full Text] [PDF]

Home page
 Circ Heart FailHome page
A. M. Katz
The "Modern" View of Heart Failure: How Did We Get Here?
Circ Heart Fail, May 1, 2008; 1(1): 63 - 71.
[Full Text] [PDF]

Home page
 Eur Heart J SupplHome page
S. G. Haworth
The cell and molecular biology of right ventricular dysfunction in pulmonary hypertension
Eur. Heart J. Suppl., December 1, 2007; 9(suppl_H): H10 - H16.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
M. Nahrendorf, F. K. Swirski, E. Aikawa, L. Stangenberg, T. Wurdinger, J.-L. Figueiredo, P. Libby, R. Weissleder, and M. J. Pittet
The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions
J. Exp. Med., November 26, 2007; 204(12): 3037 - 3047.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. Moro, M.-G. Jouan, A. Rakotovao, M.-C. Toufektsian, O. Ormezzano, N. Nagy, A. Tosaki, J. de Leiris, and F. Boucher
Delayed expression of cytokines after reperfused myocardial infarction: possible trigger for cardiac dysfunction and ventricular remodeling
Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H3014 - H3019.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
M. J. Haykowsky, Y. Liang, D. Pechter, L. W. Jones, F. A. McAlister, and A. M. Clark
A Meta-Analysis of the Effect of Exercise Training on Left Ventricular Remodeling in Heart Failure Patients: The Benefit Depends on the Type of Training Performed
J. Am. Coll. Cardiol., June 19, 2007; 49(24): 2329 - 2336.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
G. L. Brower, S. P. Levick, and J. S. Janicki
Inhibition of matrix metalloproteinase activity by ACE inhibitors prevents left ventricular remodeling in a rat model of heart failure
Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H3057 - H3064.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Heart FailHome page
P. J. Hauptman and H. N. Sabbah
Reversal of ventricular remodeling: Important to establish and difficult to define
Eur J Heart Fail, April 1, 2007; 9(4): 325 - 328.
[Full Text] [PDF]

Home page
 Eur J Heart FailHome page
J. Abdulla, S. Barlera, R. Latini, L. Kjoller-Hansen, P. Sogaard, E. Christensen, L. Kober, and C. Torp-Pedersen
A systematic review: Effect of angiotensin converting enzyme inhibition on left ventricular volumes and ejection fraction in patients with a myocardial infarction and in patients with left ventricular dysfunction
Eur J Heart Fail, February 1, 2007; 9(2): 129 - 135.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. A. Pfeffer and E. D. Frohlich
Improvements in clinical outcomes with the use of angiotensin-converting enzyme inhibitors: cross-fertilization between clinical and basic investigation
Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2021 - H2025.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
H. Thai, L. Castellano, E. Juneman, H. Phan, R. Do, M. A. Gaballa, and S. Goldman
Pretreatment With Angiotensin Receptor Blockade Prevents Left Ventricular Dysfunction and Blunts Left Ventricular Remodeling Associated With Acute Myocardial Infarction
Circulation, October 31, 2006; 114(18): 1933 - 1939.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
G. P. Zaloga, N. Ruzmetov, K. A. Harvey, C. Terry, N. Patel, W. Stillwell, and R. Siddiqui
(n-3) Long-Chain Polyunsaturated Fatty Acids Prolong Survival following Myocardial Infarction in Rats
J. Nutr., July 1, 2006; 136(7): 1874 - 1878.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
L. A. M. Zornoff, L. S. Matsubara, B. B. Matsubara, M. P. Okoshi, K. Okoshi, M. Dal Pai-Silva, R. F. Carvalho, A. C. Cicogna, C. R. Padovani, E. L. Novelli, et al.
Beta-Carotene Supplementation Attenuates Cardiac Remodeling Induced by One-Month Tobacco-Smoke Exposure in Rats
Toxicol. Sci., March 1, 2006; 90(1): 259 - 266.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
A. Leri, J. Kajstura, and P. Anversa
Cardiac Stem Cells and Mechanisms of Myocardial Regeneration
Physiol Rev, October 1, 2005; 85(4): 1373 - 1416.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
S. A. R. Paiva, L. S. Matsubara, B. B. Matsubara, M. F. Minicucci, P. S. Azevedo, A. O. Campana, and L. A. M. Zornoff
Retinoic Acid Supplementation Attenuates Ventricular Remodeling after Myocardial Infarction in Rats
J. Nutr., October 1, 2005; 135(10): 2326 - 2328.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
S. A. R. Paiva, R. Novo, B. B. Matsubara, L. S. Matsubara, P. S. Azevedo, M. F. Minicucci, A. O. Campana, and L. A. M. Zornoff
{beta}-Carotene Attenuates the Paradoxical Effect of Tobacco Smoke on the Mortality of Rats after Experimental Myocardial Infarction
J. Nutr., September 1, 2005; 135(9): 2109 - 2113.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
R. T. Cowling, X. Zhang, V. C. Reese, M. Iwata, D. Gurantz, W. H. Dillmann, and B. H. Greenberg
Effects of cytokine treatment on angiotensin II type 1A receptor transcription and splicing in rat cardiac fibroblasts
Am J Physiol Heart Circ Physiol, September 1, 2005; 289(3): H1176 - H1183.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
S. D. Solomon, H. Skali, N. S. Anavekar, M. Bourgoun, S. Barvik, J. K. Ghali, J. W. Warnica, M. Khrakovskaya, J. M. O. Arnold, Y. Schwartz, et al.
Changes in Ventricular Size and Function in Patients Treated With Valsartan, Captopril, or Both After Myocardial Infarction
Circulation, June 28, 2005; 111(25): 3411 - 3419.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
H. Otani, Y. Kagaya, Y. Imahori, S. Yasuda, R. Fujii, M. Chida, S. Namiuchi, M. Takeda, M. Sakuma, J. Watanabe, et al.
Myocardial 11C-Diacylglycerol Accumulation and Left Ventricular Remodeling in Patients After Myocardial Infarction
J. Nucl. Med., April 1, 2005; 46(4): 553 - 559.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
L. H. Opie
Cellular Basis for Therapeutic Choices in Heart Failure
Circulation, October 26, 2004; 110(17): 2559 - 2561.
[Full Text] [PDF]

Home page
 HypertensionHome page
I. M.C. Dixon and V. Drobic
Gender Dependency in the Pathogenesis of Cardiac Hypertrophy: Effect of Norepinephrine on Transforming Growth Factor-{beta} Release in Female Heart
Hypertension, October 1, 2004; 44(4): 392 - 393.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. Berthonneche, T. Sulpice, F. Boucher, L. Gouraud, J. de Leiris, S. E. O'Connor, J.-M. Herbert, and P. Janiak
New insights into the pathological role of TNF-{alpha} in early cardiac dysfunction and subsequent heart failure after infarction in rats
Am J Physiol Heart Circ Physiol, July 1, 2004; 287(1): H340 - H350.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
K. Hu, A. Naumann, D. Fraccarollo, P. Gaudron, J. J. Kaden, S. Neubauer, and G. Ertl
Heart rate reduction by zatebradine reduces infarct size and mortality but promotes remodeling in rats with experimental myocardial infarction
Am J Physiol Heart Circ Physiol, April 1, 2004; 286(4): H1281 - H1288.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. Nahrendorf, K.-H. Hiller, A. Greiser, S. Kohler, T. Neuberger, K. Hu, C. Waller, M. Albrecht, S. Neubauer, A. Haase, et al.
Chronic coronary artery stenosis induces impaired function of remote myocardium: MRI and spectroscopy study in rat
Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2712 - H2721.
[Abstract] [Full Text] [PDF]

Home page
 Journal of Renin-Angiotensin-Aldosterone SystemHome page
W. Linz, G. Itter, L. W Dobrucki, T. Malinski, and G. Wiemer
Ramipril improves nitric oxide availability in hypertensive rats with failing hearts after myocardial infarction
Journal of Renin-Angiotensin-Aldosterone System, September 1, 2003; 4(3): 180 - 185.
[Abstract] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. A. R. de Paiva, L. A. M. Zornoff, M. P. Okoshi, K. Okoshi, L. S. Matsubara, B. B. Matsubara, A. C. Cicogna, and A. O. Campana
Ventricular remodeling induced by retinoic acid supplementation in adult rats
Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H2242 - H2246.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
T. Sugie, Y. Kagaya, M. Takeda, H. Yahagi, C. Takahashi, J. Takahashi, M. Ninomiya, J. Watanabe, R. Ichinohasama, F. Tezuka, et al.
Should increasing the dose or adding an AT1 receptor blocker follow a relatively low dose of ACE inhibitor initiated in acute myocardial infarction?
Cardiovasc Res, June 1, 2003; 58(3): 611 - 620.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. Nahrendorf, K. Hu, D. Fraccarollo, K.-H. Hiller, A. Haase, W. R. Bauer, and G. Ertl
Time course of right ventricular remodeling in rats with experimental myocardial infarction
Am J Physiol Heart Circ Physiol, January 1, 2003; 284(1): H241 - H248.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
M. Nahrendorf, K. Hu, K.-H. Hiller, P. Galuppo, D. Fraccarollo, G. Schweizer, A. Haase, G. Ertl, W. R. Bauer, and J. Bauersachs
Impact of hydroxymethylglutaryl coenzyme a reductase inhibition on left ventricular remodeling after myocardial infarction: An experimental serial cardiac magnetic resonance imaging study
J. Am. Coll. Cardiol., November 6, 2002; 40(9): 1695 - 1700.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Heart FailHome page
M. Vaynblat, H. R. Shah, D. Bhaskaran, G. Ramdev, W. J. Davis III, J. N. Cunningham Jr., and M. Chiavarelli
Simultaneous angiotensin converting enzyme inhibition moderates ventricular dysfunction caused by doxorubicin
Eur J Heart Fail, October 1, 2002; 4(5): 583 - 586.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
B. K. Podesser, J. Schirnhofer, O. Y. Bernecker, A. Kroner, M. Franz, S. Semsroth, B. Fellner, J. Neumuller, S. Hallstrom, and E. Wolner
Optimizing Ischemia/Reperfusion in the Failing Rat Heart--Improved Myocardial Protection With Acute ACE Inhibition
Circulation, September 24, 2002; 106(12_suppl_1): I-277 - I-283.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
M. Saeed, N. Watzinger, G. A. Krombach, G. K. Lund, M. F. Wendland, M. Chujo, and C. B. Higgins
Left Ventricular Remodeling after Infarction: Sequential MR Imaging with Oral Nicorandil Therapy in Rat Model
Radiology, September 1, 2002; 224(3): 830 - 837.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
P. Mulder, H. Boujedaini, V. Richard, J.-P. Henry, S. Renet, K. Munter, and C. Thuillez
Long-Term Survival and Hemodynamics After Endothelin-A Receptor Antagonism and Angiotensin-Converting Enzyme Inhibition in Rats With Chronic Heart Failure: Monotherapy Versus Combination Therapy
Circulation, August 27, 2002; 106(9): 1159 - 1164.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
R. Gaertner, F. Prunier, M. Philippe, L. Louedec, J.-J. Mercadier, and J.-B. Michel
Scar and pulmonary expression and shedding of ACE in rat myocardial infarction
Am J Physiol Heart Circ Physiol, July 1, 2002; 283(1): H156 - H164.
[Abstract] [Full Text] [PDF]

Home page
 J CARDIOVASC PHARMACOL THERHome page
B. I. Jugdutt and V. Menon
Beneficial Effects of Therapy on the Progression of Structural Remodeling During Healing After Reperfused and Nonreperfused Myocardial Infarction: Different Effects on Different Parameters
Journal of Cardiovascular Pharmacology and Therapeutics, June 1, 2002; 7(2): 95 - 107.
[Abstract] [PDF]

Home page
 Cardiovasc ResHome page
D. Fraccarollo, J. Bauersachs, M. Kellner, P. Galuppo, and G. Ertl
Cardioprotection by long-term ETA receptor blockade and ACE inhibition in rats with congestive heart failure: mono- versus combination therapy
Cardiovasc Res, April 1, 2002; 54(1): 85 - 94.
[Abstract] [Full Text] [PDF]

Home page
 Journal of Renin-Angiotensin-Aldosterone SystemHome page
Yuejin Yang, Yida Tang, Yingmao Ruan, Yongli Li, Yanwen Zhou, Runlin Gao, Jilin Chen, and Zaijia Chen
Comparative effects of cilazapril, carvedilol and their combination in preventing from left ventricular remodelling after acute myocardial infarction in rats
Journal of Renin-Angiotensin-Aldosterone System, March 1, 2002; 3(1): 31 - 35.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
R. T. Cowling, D. Gurantz, J. Peng, W. H. Dillmann, and B. H. Greenberg
Transcription Factor NF-kappa B Is Necessary for Up-regulation of Type 1 Angiotensin II Receptor mRNA in Rat Cardiac Fibroblasts Treated with Tumor Necrosis Factor-alpha or Interleukin-1beta
J. Biol. Chem., February 15, 2002; 277(8): 5719 - 5724.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
W. Zhang
Old and new tools to dissect calcineurin's role in pressure-overload cardiac hypertrophy
Cardiovasc Res, February 1, 2002; 53(2): 294 - 303.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
B. I. Jugdutt
Monocytosis and adverse left ventricular remodeling after reperfused myocardial infarction
J. Am. Coll. Cardiol., January 16, 2002; 39(2): 247 - 250.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J.-Y. Min, Y. Yang, K. L. Converso, L. Liu, Q. Huang, J. P. Morgan, and Y.-F. Xiao
Transplantation of embryonic stem cells improves cardiac function in postinfarcted rats
J Appl Physiol, January 1, 2002; 92(1): 288 - 296.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
J. A. Wagner, K. Hu, J. Bauersachs, J. Karcher, M. Wiesler, S. K. Goparaju, G. Kunos, and G. Ertl
Endogenous cannabinoids mediate hypotension after experimental myocardial infarction
J. Am. Coll. Cardiol., December 1, 2001; 38(7): 2048 - 2054.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
B. Pouzet, S. Ghostine, J.-T. Vilquin, I. Garcin, M. Scorsin, A. A. Hagege, D. Duboc, K. Schwartz, and P. Menasche
Is Skeletal Myoblast Transplantation Clinically Relevant in the Era of Angiotensin-Converting Enzyme Inhibitors?
Circulation, September 18, 2001; 104 (2009): I-223 - I-228.
[Abstract] [Full Text] [PDF]

Home page
 J CARDIOVASC PHARMACOL THERHome page
M. E. Khalil, E. N. Heller, F. Boctor, E. J. Brown Jr, and I. A. Alhaddad
Ventricular Free Wall Rupture in Acute Myocardial Infarction
Journal of Cardiovascular Pharmacology and Therapeutics, September 1, 2001; 6(3): 231 - 236.
[Abstract] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. A. Delyani, E. L. Robinson, and A. E. Rudolph
Effect of a selective aldosterone receptor antagonist in myocardial infarction
Am J Physiol Heart Circ Physiol, August 1, 2001; 281(2): H647 - H654.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
S. Mankad, T. A. d'Amato, N. Reichek, W. E. McGregor, J. Lin, D. Singh, W. J. Rogers, and C. M. Kramer
Combined Angiotensin II Receptor Antagonism and Angiotensin-Converting Enzyme Inhibition Further Attenuates Postinfarction Left Ventricular Remodeling
Circulation, June 12, 2001; 103(23): 2845 - 2850.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
M. E. Khalil, A. W. Basher, E. J. Brown Jr, and I. A. Alhaddad
A remarkable medical story: benefits of angiotensin-converting enzyme inhibitors in cardiac patients
J. Am. Coll. Cardiol., June 1, 2001; 37(7): 1757 - 1764.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
E. Braunwald
Congestive heart failure: a half century perspective
Eur. Heart J., May 2, 2001; 22(10): 825 - 836.
[PDF]

Home page
 CirculationHome page
H. Jin, R. Yang, T. A. Awad, F. Wang, W. Li, S.-P. Williams, A. Ogasawara, B. Shimada, P. M. Williams, G. de Feo, et al.
Effects of Early Angiotensin-Converting Enzyme Inhibition on Cardiac Gene Expression After Acute Myocardial Infarction
Circulation, February 6, 2001; 103(5): 736 - 742.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
R. Varin, P. Mulder, F. Tamion, V. Richard, J.-P. Henry, F. Lallemand, G. Lerebours, and C. Thuillez
Improvement of Endothelial Function by Chronic Angiotensin-Converting Enzyme Inhibition in Heart Failure : Role of Nitric Oxide, Prostanoids, Oxidant Stress, and Bradykinin
Circulation, July 18, 2000; 102(3): 351 - 356.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
J. Bauersachs, D. Fraccarollo, P. Galuppo, J. Widder, and G. Ertl
Endothelin-receptor blockade improves endothelial vasomotor dysfunction in heart failure
Cardiovasc Res, July 1, 2000; 47(1): 142 - 149.
[Abstract] [Full Text] [PDF]

Home page
 Journal of Renin-Angiotensin-Aldosterone SystemHome page
M. A Pfeffer
Will more complete inhibition of the RAAS with angiotensin receptor blockade improve survival following myocardial infarction?
Journal of Renin-Angiotensin-Aldosterone System, June 1, 2000; 1(2_suppl): S41 - S43.
[Abstract] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J.-Y. Min, T. G. Hampton, J.-F. Wang, J. DeAngelis, and J. P. Morgan
Depressed tolerance to fluorocarbon-simulated ischemia in failing myocardium due to impaired [Ca2+]i modulation
Am J Physiol Heart Circ Physiol, May 1, 2000; 278(5): H1446 - H1456.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
M. Jain, R. Liao, S. Ngoy, P. Whittaker, C. S. Apstein, and F. R. Eberli
Angiotensin II receptor blockade attenuates the deleterious effects of exercise training on post-MI ventricular remodelling in rats
Cardiovasc Res, April 1, 2000; 46(1): 66 - 72.
[Abstract] [Full Text] [PDF]

Home page
 Asian Cardiovasc. Thorac. Ann.Home page
Y. Z. Zhu, H. S. Lee, Y. Z. Zhu, and H. S. Lee
Angiotensin-Converting Enzyme Inhibition After Myocardial Infarction
Asian Cardiovasc Thorac Ann, March 1, 2000; 8(1): 85 - 90.
[Abstract] [Full Text] [PDF]

Home page
 J CARDIOVASC PHARMACOL THERHome page
L. A.M. Zornoff, S. A.R. Paiva, B. B. Matsubara, L. S. Matsubara, and J. Spadaro
Combination Therapy with Angiotensin Converting Enzyme Inhibition and AT1 Receptor Inhibitor on Ventricular Remodeling After Myocardial Infarction in Rats
Journal of Cardiovascular Pharmacology and Therapeutics, January 1, 2000; 5(3): 203 - 209.
[Abstract] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
J.-Y. Min, S. Sandmann, A. Meissner, T. Unger, and R. Simon
Differential Effects of Mibefradil, Verapamil, and Amlodipine on Myocardial Function and Intracellular Ca2+ Handling in Rats with Chronic Myocardial Infarction
J. Pharmacol. Exp. Ther., December 1, 1999; 291(3): 1038 - 1044.
[Abstract] [Full Text]

Home page
 Cardiovasc ResHome page
J. P.M Cleutjens, W.M. Blankesteijn, M. J.A.P Daemen, and J. F.M Smits
The infarcted myocardium: Simply dead tissue, or a lively target for therapeutic interventions
Cardiovasc Res, November 1, 1999; 44(2): 232 - 241.
[Full Text] [PDF]

Home page
 Cardiovasc ResHome page
K. C Wollert and H. Drexler
The renin-angiotensin system and experimental heart failure
Cardiovasc Res, September 1, 1999; 43(4): 838 - 849.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
D. L. Ceiler, M. Nelissen-Vrancken, J. G.R. De Mey, and J. F.M. Smits
Role of basal nitric oxide synthesis in vasoconstrictor hyporeactivity in the perfused rat hindlimb after myocardial infarction: effect of captopril
Cardiovasc Res, August 15, 1999; 43(3): 779 - 787.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
D. Gurantz, R. T. Cowling, F. J. Villarreal, and B. H. Greenberg
Tumor Necrosis Factor-{alpha} Upregulates Angiotensin II Type 1 Receptors on Cardiac Fibroblasts
Circ. Res., August 6, 1999; 85(3): 272 - 279.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
J. Bauersachs, A. Bouloumie, D. Fraccarollo, K. Hu, R. Busse, and G. Ertl
Endothelial Dysfunction in Chronic Myocardial Infarction Despite Increased Vascular Endothelial Nitric Oxide Synthase and Soluble Guanylate Cyclase Expression : Role of Enhanced Vascular Superoxide Production
Circulation, July 20, 1999; 100(3): 292 - 298.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
C. Marie, C. Mossiat, C. Gros, J.-C. Schwartz, J.-M. Lecomte, and J. Bralet
Effect of long-term therapy with fasidotril, a mixed inhibitor of neprilysin and angiotensin-converting enzyme (ACE), on survival of rats after myocardial infarction
Cardiovasc Res, March 1, 1999; 41(3): 544 - 553.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
J. K. French, D. J. Amos, B. F. Williams, D. B. Cross, J. M. Elliott, H. H. Hart, M. G. Williams, R. M. Norris, N. G. Ashton, R. M. L. Whitlock, et al.
Effects of early captopril administration after thrombolysis on regional wall motion in relation to infarct artery blood flow
J. Am. Coll. Cardiol., January 1, 1999; 33(1): 139 - 145.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
N. Nagaya, T. Nishikimi, T. Horio, F. Yoshihara, A. Kanazawa, H. Matsuo, and K. Kangawa
Cardiovascular and renal effects of adrenomedullin in rats with heart failure
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 1999; 276(1): R213 - R218.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
C. Richer, P. Fornes, C. Cazaubon, V. Domergue, D. Nisato, and J.-F. Giudicelli
Effects of long-term angiotensin II AT1 receptor blockade on survival, hemodynamics and cardiac remodeling in chronic heart failure in rats
Cardiovasc Res, January 1, 1999; 41(1): 100 - 108.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
A. Hammes, S. Oberdorf-Maass, T. Rother, K. Nething, F. Gollnick, K. W. Linz, R. Meyer, K. Hu, H. Han, P. Gaudron, et al.
Overexpression of the Sarcolemmal Calcium Pump in the Myocardium of Transgenic Rats
Circ. Res., November 2, 1998; 83(9): 877 - 888.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
P. Mulder, V. Richard, F. Bouchart, G. Derumeaux, K. Munter, and C. Thuillez
Selective ETA receptor blockade prevents left ventricular remodeling and deterioration of cardiac function in experimental heart failure
Cardiovasc Res, September 1, 1998; 39(3): 600 - 608.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
H. V. Barron, A. D. Michaels, C. Maynard, N. R. Every, and for the National Registry of Myocardial Infarction
Use of angiotensin-converting enzyme inhibitors at discharge in patients with acute myocardial infarction in the United States: data from the National Registry of Myocardial Infarction 2
J. Am. Coll. Cardiol., August 1, 1998; 32(2): 360 - 367.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
K. Hu, P. Gaudron, H.-J. Anders, F. Weidemann, O. Turschner, M. Nahrendorf, and G. Ertl
Chronic effects of early started angiotensin converting enzyme inhibition and angiotensin AT1-receptor subtype blockade in rats with myocardial infarction: role of bradykinin
Cardiovasc Res, August 1, 1998; 39(2): 401 - 412.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
M. A. Pfeffer
ACE Inhibitors in Acute Myocardial Infarction : Patient Selection and Timing
Circulation, June 9, 1998; 97(22): 2192 - 2194.
[Full Text] [PDF]

Home page
 CirculationHome page
N. J. Brown and D. E. Vaughan
Angiotensin-Converting Enzyme Inhibitors
Circulation, April 14, 1998; 97(14): 1411 - 1420.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
D. Grimm, D. Elsner, H. Schunkert, M. Pfeifer, D. Griese, G. Bruckschlegel, F. Muders, G. A.J Riegger, and E. P Kromer
Development of heart failure following isoproterenol administration in the rat: role of the renin-angiotensin system
Cardiovasc Res, January 1, 1998; 37(1): 91 - 100.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
R. G Schoemaker, P. R Saxena, and E. A.J Kalkman
Low-dose aspirin improves in vivo hemodynamics in conscious, chronically infarcted rats
Cardiovasc Res, January 1, 1998; 37(1): 108 - 114.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
D. Fraccarollo, K. Hu, P. Galuppo, P. Gaudron, and G. Ertl
Chronic Endothelin Receptor Blockade Attenuates Progressive Ventricular Dilation and Improves Cardiac Function in Rats With Myocardial Infarction : Possible Involvement of Myocardial Endothelin System in Ventricular Remodeling
Circulation, December 2, 1997; 96(11): 3963 - 3973.
[Abstract] [Full Text]

Home page
 CirculationHome page
I. S. Anand, D. Liu, S. S. Chugh, A. J.C. Prahash, S. Gupta, R. John, F. Popescu, and Y. Chandrashekhar
Isolated Myocyte Contractile Function Is Normal in Postinfarct Remodeled Rat Heart With Systolic Dysfunction
Circulation, December 2, 1997; 96(11): 3974 - 3984.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
T. E. Raya, M. Gaballa, P. Anderson, and S. Goldman
Left ventricular function and remodeling after myocardial infarction in aging rats
Am J Physiol Heart Circ Physiol, December 1, 1997; 273(6): H2652 - H2658.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
T. Nishikimi, T. Horio, T. Sasaki, F. Yoshihara, S. Takishita, A. Miyata, H. Matsuo, and K. Kangawa
Cardiac Production and Secretion of Adrenomedullin Are Increased in Heart Failure
Hypertension, December 1, 1997; 30(6): 1369 - 1375.
[Abstract] [Full Text]

Home page
 CirculationHome page
M. St. J. Sutton, M. A. Pfeffer, L. Moye, T. Plappert, J. L. Rouleau, G. Lamas, J. Rouleau, J. O. Parker, M. O. Arnold, B. Sussex, et al.
Cardiovascular Death and Left Ventricular Remodeling Two Years After Myocardial Infarction : Baseline Predictors and Impact of Long-term Use of Captopril: Information From the Survival and Ventricular Enlargement (SAVE) Trial
Circulation, November 18, 1997; 96(10): 3294 - 3299.
[Abstract] [Full Text]

Home page
 HypertensionHome page
T. A. Fischer, P. L. McNeil, R. Khakee, P. Finn, R. A. Kelly, M. A. Pfeffer, and J. M. Pfeffer
Cardiac Myocyte Membrane Wounding in the Abruptly Pressure-Overloaded Rat Heart Under High Wall Stress
Hypertension, November 1, 1997; 30(5): 1041 - 1046.
[Abstract] [Full Text]

Home page
 HypertensionHome page
M. Flesch, F. Schiffer, O. Zolk, Y. Pinto, S. Rosenkranz, C. Hirth-Dietrich, G. Arnold, M. Paul, and M. Bohm
Contractile Systolic and Diastolic Dysfunction in Renin-Induced Hypertensive Cardiomyopathy
Hypertension, September 1, 1997; 30(3): 383 - 391.
[Abstract] [Full Text]

Home page
 CirculationHome page
M. A. Pfeffer, S. C. Greaves, J. M. O. Arnold, R. J. Glynn, F. S. LaMotte, R. T. Lee, F. J. Menapace Jr, E. Rapaport, P. M. Ridker, J.-L. Rouleau, et al.
Early Versus Delayed Angiotensin-Converting Enzyme Inhibition Therapy in Acute Myocardial Infarction : The Healing and Early Afterload Reducing Therapy Trial
Circulation, June 17, 1997; 95(12): 2643 - 2651.
[Abstract] [Full Text]

Home page
 CirculationHome page
E. O. Weinberg, M. A. Lee, M. Weigner, K. Lindpaintner, S. P. Bishop, C. R. Benedict, K. K. L. Ho, P. S. Douglas, E. Chafizadeh, and B. H. Lorell
Angiotensin AT1 Receptor Inhibition : Effects on Hypertrophic Remodeling and ACE Expression in Rats With Pressure-Overload Hypertrophy due to Ascending Aortic Stenosis
Circulation, March 18, 1997; 95(6): 1592 - 1600.
[Abstract] [Full Text]

Home page
 CirculationHome page
P. Mulder, B. Devaux, V. Richard, J.-P. Henry, M.-C. Wimart, E. Thibout, B. Mace, and C. Thuillez
Early Versus Delayed Angiotensin-Converting Enzyme Inhibition in Experimental Chronic Heart Failure: Effects on Survival, Hemodynamics, and Cardiovascular Remodeling
Circulation, March 4, 1997; 95(5): 1314 - 1319.
[Abstract] [Full Text]

Home page
 CirculationHome page
Y. Kagaya, R. J. Hajjar, J. K. Gwathmey, W. H. Barry, and B. H. Lorell
Long-term Angiotensin-Converting Enzyme Inhibition With Fosinopril Improves Depressed Responsiveness to Ca2+ in Myocytes From Aortic-Banded Rats
Circulation, December 1, 1996; 94(11): 2915 - 2922.
[Abstract] [Full Text]

Home page
 CirculationHome page
E. J. Eichhorn and M. R. Bristow
Medical Therapy Can Improve the Biological Properties of the Chronically Failing Heart: A New Era in the Treatment of Heart Failure
Circulation, November 1, 1996; 94(9): 2285 - 2296.
[Abstract] [Full Text]

Home page
 Circ. Res.Home page
A. Simonini, C. S. Long, G. A. Dudley, P. Yue, J. McElhinny, and B. M. Massie
Heart Failure in Rats Causes Changes in Skeletal Muscle Morphology and Gene Expression That Are Not Explained by Reduced Activity
Circ. Res., July 1, 1996; 79(1): 128 - 136.
[Abstract] [Full Text]

Home page
 CirculationHome page
B. I. Jugdutt, M. J. Joljart, and M. I. Khan
Rate of Collagen Deposition During Healing and Ventricular Remodeling After Myocardial Infarction in Rat and Dog Models
Circulation, July 1, 1996; 94(1): 94 - 101.
[Abstract] [Full Text]


Circulation Research Home | Subscriptions | Archives | Feedback | Authors | Help | AHA Journals Home | Search
Copyright © 1985 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited.