Circulation Research, Vol 53, 306-318, Copyright © 1983 by American Heart Association

ARTICLES

Effect of positive inotropic agents on the relation between oxygen consumption and systolic pressure volume area in canine left ventricle

H Suga, R Hisano, Y Goto, O Yamada and Y Igarashi

We analyzed the effect of positive inotropic agents on the relation between left ventricular oxygen consumption and the systolic pressure- volume area. Pressure-volume area is a measure of total mechanical energy for ventricular contraction, and is a specific area in the ventricular pressure-volume diagram circumscribed by the end-systolic and end-diastolic pressure-volume relation curves and the systolic segment of the pressure-volume trajectory. Either epinephrine (1 microgram/kg per min, iv) or calcium ion (0.03 mEq/kg per min, iv) was administered to canine excised cross-circulated hearts. These agents increased an index of ventricular contractility, Emax, or the slope of the end-systolic pressure-volume line, by 70%. The regression lines of ventricular oxygen consumption on pressure-volume area in control and in enhanced contractile states were of the same formula: ventricular oxygen consumption (ml O2/beat per 100 g) equals A times pressure- volume area (mm Hg ml/beat per 100 g) plus a constant B. Coefficient A remained unchanged at 1.8 X 10(-5) ml oxygen/(mm Hg ml), but constant B increased from 0.03 ml oxygen/beat per 100 g by more than 50% with either agent. The reciprocal of A reflects the energy conversion efficiency for the total mechanical energy, and this efficiency remained near 36%. The increase in B was equal to the directly measured increment in ventricular oxygen consumption for mechanically unloaded contraction. The basal metabolism remained unchanged. We conclude that the augmented oxygen consumption under the acutely enhanced contractile state with either epinephrine or calcium was caused primarily by an increased energy utilization associated with the excitation-contraction coupling.

This article has been cited by other articles:

				T. A. Quinn, S. E. Cabreriza, M. E. Richmond, A. D. Weinberg, J. W. Holmes, and H. M. Spotnitz Simultaneous variation of ventricular pacing site and timing with biventricular pacing in acute ventricular failure improves function by interventricular assist Am J Physiol Heart Circ Physiol, December 1, 2009; 297(6): H2220 - H2226. [Abstract] [Full Text] [PDF]

				A. Akki and A.-M. L. Seymour Western diet impairs metabolic remodelling and contractile efficiency in cardiac hypertrophy Cardiovasc Res, February 15, 2009; 81(3): 610 - 617. [Abstract] [Full Text] [PDF]

				T. Tsuji, F. del Monte, Y. Yoshikawa, T. Abe, J. Shimizu, C. Nakajima-Takenaka, S. Taniguchi, R. J. Hajjar, and M. Takaki Rescue of Ca2+ overload-induced left ventriclur dysfunction by targeted ablation of phospholamban Am J Physiol Heart Circ Physiol, February 1, 2009; 296(2): H310 - H317. [Abstract] [Full Text] [PDF]

				K. Meyer, R. C. Klocke, J. D. Schipke, E. Gams, and B. Korbmacher Ca(2+) sensitizer superior to catecholamine during myocardial stunning? Eur. J. Cardiothorac. Surg., August 1, 2008; 34(2): 326 - 331. [Abstract] [Full Text] [PDF]

				M. Osranek, J. H. Eisenach, B. K. Khandheria, K. Chandrasekaran, J. B. Seward, and M. Belohlavek Arterioventricular Coupling and Ventricular Efficiency After Antihypertensive Therapy: A Noninvasive Prospective Study Hypertension, February 1, 2008; 51(2): 275 - 281. [Abstract] [Full Text] [PDF]

				O.-J. How, E. Aasum, D. L. Severson, W.Y. A. Chan, M. F. Essop, and T. S. Larsen Increased Myocardial Oxygen Consumption Reduces Cardiac Efficiency in Diabetic Mice Diabetes, February 1, 2006; 55(2): 466 - 473. [Abstract] [Full Text] [PDF]

				S. Kobayashi, Y. Yoshikawa, S. Sakata, C. Takenaka, H. Hagihara, Y. Ohga, T. Abe, S. Taniguchi, and M. Takaki Left ventricular mechanoenergetics after hyperpolarized cardioplegic arrest by nicorandil and after depolarized cardioplegic arrest by KCl Am J Physiol Heart Circ Physiol, September 1, 2004; 287(3): H1072 - H1080. [Abstract] [Full Text] [PDF]

				T. Ramanathan, S. Morita, Y. Huang, K. Shirota, T. Nishimura, X. Zheng, and S. N. Hunyor Glucose-insulin-potassium solution improves left ventricular energetics in chronic ovine diabetes Ann. Thorac. Surg., April 1, 2004; 77(4): 1408 - 1414. [Abstract] [Full Text] [PDF]

				T. Ramanathan, K. Shirota, S. Morita, T. Nishimura, Y. Huang, X. Zheng, and S. Hunyor Left ventricular oxygen utilization efficiency is impaired in chronic streptozotocin-diabetic sheep Cardiovasc Res, September 1, 2002; 55(4): 749 - 756. [Abstract] [Full Text] [PDF]

				T. Abe, Y. Ohga, N. Tabayashi, S. Kobayashi, S. Sakata, H. Misawa, T. Tsuji, H. Kohzuki, H. Suga, S. Taniguchi, et al. Left ventricular diastolic dysfunction in type 2 diabetes mellitus model rats Am J Physiol Heart Circ Physiol, January 1, 2002; 282(1): H138 - H148. [Abstract] [Full Text] [PDF]

				T. Tsuji, Y. Ohga, Y. Yoshikawa, S. Sakata, T. Abe, N. Tabayashi, S. Kobayashi, H. Kohzuki, K.-I. Yoshida, H. Suga, et al. Rat cardiac contractile dysfunction induced by Ca2+ overload: possible link to the proteolysis of {alpha}-fodrin Am J Physiol Heart Circ Physiol, September 1, 2001; 281(3): H1286 - H1294. [Abstract] [Full Text] [PDF]

				A. Saeki, Y. Goto, K. Hata, T. Takasago, T. Nishioka, and H. Suga Negative inotropism of hyperthermia increases oxygen cost of contractility in canine hearts Am J Physiol Heart Circ Physiol, December 1, 2000; 279(6): H2855 - H2864. [Abstract] [Full Text] [PDF]

				U. Sunderdiek, B. Korbmacher, E. Gams, and J. D. Schipke Myocardial efficiency in stunned myocardium. Comparison of Ca2+-sensitization and PDE III-inhibition on energy consumption Eur. J. Cardiothorac. Surg., July 1, 2000; 18(1): 83 - 89. [Abstract] [Full Text] [PDF]

				J. Shimizu, J. Araki, G. Iribe, T. Imaoka, S. Mohri, K. Kohno, H. Matsubara, T. Ohe, M. Takaki, and H. Suga Postextrasystolic contractile decay always contains exponential and alternans components in canine heart Am J Physiol Heart Circ Physiol, July 1, 2000; 279(1): H225 - H233. [Abstract] [Full Text] [PDF]

				U. E. G. Ekelund, R. W. Harrison, O. Shokek, R. N. Thakkar, R. S. Tunin, H. Senzaki, D. A. Kass, E. Marban, and J. M. Hare Intravenous Allopurinol Decreases Myocardial Oxygen Consumption and Increases Mechanical Efficiency in Dogs With Pacing-Induced Heart Failure Circ. Res., September 3, 1999; 85(5): 437 - 445. [Abstract] [Full Text] [PDF]

				T. Mikane, J. Araki, S. Suzuki, J. Mizuno, J. Shimizu, S. Mohri, H. Matsubara, M. Hirakawa, T. Ohe, and H. Suga O2 cost of contractility but not of mechanical energy increases with temperature in canine left ventricle Am J Physiol Heart Circ Physiol, July 1, 1999; 277(1): H65 - H73. [Abstract] [Full Text] [PDF]

				H. Kohzuki, H. Misawa, S. Sakata, Y. Ohga, H. Suga, and M. Takaki Energy expenditure by Ba2+ contracture in rat ventricular slices derives from cross-bridge cycling Am J Physiol Heart Circ Physiol, July 1, 1999; 277(1): H74 - H79. [Abstract] [Full Text] [PDF]

				C. Korvald, O. P. Elvenes, L. M. Ytrebo, D. G. Sorlie, and T. Myrmel Oxygen-wasting effect of inotropy  in the "virtual work model" Am J Physiol Heart Circ Physiol, April 1, 1999; 276(4): H1339 - H1345. [Abstract] [Full Text] [PDF]

				O. Kawaguchi, W. E. Pae, B. B. Daily, and W. S. Pierce VENTRICULOARTERIAL COUPLING WITH INTRA-AORTIC BALLOON PUMP IN ACUTE ISCHEMIC HEART FAILURE J. Thorac. Cardiovasc. Surg., January 1, 1999; 117(1): 164 - 171. [Abstract] [Full Text] [PDF]

				O. Kawaguchi, Y. Huang, T. Yuasa, C. J. Horam, R. J. Carrington, Z. Biao, P. W. Brady, M. Murase, and S. N. Hunyor Improved efficiency of energy transfer to external work in chronic cardiomyoplasty based on the pressure-volume relationship J. Thorac. Cardiovasc. Surg., June 1, 1998; 115(6): 1358 - 1366. [Abstract] [Full Text] [PDF]

				I. Morii, Y. Kihara, M. Inoko, and S. Sasayama Myocardial Contractile Efficiency and Oxygen Cost of Contractility Are Preserved During Transition From Compensated Hypertrophy to Failure in Rats With Salt-Sensitive Hypertension Hypertension, April 1, 1998; 31(4): 949 - 960. [Abstract] [Full Text] [PDF]

				J. D. Schipke, B. Korbmacher, U. Schwanke, D. Frehen, T. Schmidt, and G. Arnold Basal metabolism does not account for high O2 consumption in stunned myocardium Am J Physiol Heart Circ Physiol, March 1, 1998; 274(3): H743 - H746. [Abstract] [Full Text] [PDF]

				T. Mikane, J. Araki, K. Kohno, Y. Nakayama, S. Suzuki, J. Shimizu, H. Matsubara, M. Hirakawa, M. Takaki, and H. Suga Mechanism of constant contractile efficiency under cooling inotropy of myocardium: simulation Am J Physiol Heart Circ Physiol, December 1, 1997; 273(6): H2891 - H2898. [Abstract] [Full Text] [PDF]

				A. E. Consolini, M. T. Marquez, and J. E. Ponce-Hornos Energetics of heart muscle contraction under high K perfusion: verapamil and Ca effects Am J Physiol Heart Circ Physiol, November 1, 1997; 273(5): H2343 - H2350. [Abstract] [Full Text] [PDF]

				K. Onishi, K. Sekioka, R. Ishisu, Y. Abe, H. Tanaka, M. Nakamura, Y. Ueda, and T. Nakano MCI-154, a Ca2+ sensitizer, decreases the oxygen cost of contractility in isolated canine hearts Am J Physiol Heart Circ Physiol, October 1, 1997; 273(4): H1688 - H1695. [Abstract] [Full Text] [PDF]

				J. Zhang, C. Toher, M. Erhard, Y. Zhang, K. Ugurbil, R. J. Bache, T. Lange, and D. C. Homans Relationships Between Myocardial Bioenergetic and Left Ventricular Function in Hearts With Volume-Overload Hypertrophy Circulation, July 1, 1997; 96(1): 334 - 343. [Abstract] [Full Text]

				O. Kawaguchi, Y. Goto, Y. Ohgoshi, H. Yaku, M. Murase, and H. Suga DYNAMIC CARDIAC COMPRESSION IMPROVES CONTRACTILE EFFICIENCY OF THE HEART J. Thorac. Cardiovasc. Surg., May 1, 1997; 113(5): 923 - 931. [Abstract] [Full Text]

				G. Hasenfuss, L. A. Mulieri, P. D. Allen, H. Just, and N.R. Alpert Influence of Isoproterenol and Ouabain on Excitation-Contraction Coupling, Cross-Bridge Function, and Energetics in Failing Human Myocardium Circulation, December 15, 1996; 94(12): 3155 - 3160. [Abstract] [Full Text]

				Y. Tanoue, S. Morita, Y. Ochiai, M. Hisahara, M. Masuda, Y. Kawachi, R. Tominaga, and H. Yasui INHIBITION OF LIPID PEROXIDATION WITH THE LAZAROID U74500A ATTENUATES ISCHEMIA-REPERFUSION INJURY IN A CANINE ORTHOTOPIC HEART TRANSPLANTATION MODEL J. Thorac. Cardiovasc. Surg., October 1, 1996; 112(4): 1017 - 1026. [Abstract] [Full Text]

				H. A. Skopicki, S. A. Abraham, N. J. Weissman, A. K. Mukerjee, N. M. Alpert, A. J. Fischman, M. H. Picard, and H. Gewirtz Factors Influencing Regional Myocardial Contractile Response to Inotropic Stimulation: Analysis in Humans With Stable Ischemic Heart Disease Circulation, August 15, 1996; 94(4): 643 - 650. [Abstract] [Full Text]

				Y. Hayashi, M. Takeuchi, H. Takaoka, K. Hata, M. Mori, and M. Yokoyama Alteration in Energetics in Patients With Left Ventricular Dysfunction After Myocardial Infarction : Increased Oxygen Cost of Contractility Circulation, March 1, 1996; 93(5): 932 - 939. [Abstract] [Full Text]

				H. Matsubara, M. Takaki, S. Yasuhara, J. Araki, and H. Suga Logistic Time Constant of Isovolumic Relaxation Pressure–Time Curve in the Canine Left Ventricle : Better Alternative to Exponential Time Constant Circulation, October 15, 1995; 92(8): 2318 - 2326. [Abstract] [Full Text]

				O. Kawaguchi, W. E. Pae, W. B. Daily, J. S. Sapirstein, and W. S. Pierce Left ventricular mechanoenergetics during asynchronous left atrial-to-aortic bypass: Effects of pumping rate on cardiac workload and myocardial oxygen consumption J. Thorac. Cardiovasc. Surg., September 1, 1995; 110(3): 793 - 799. [Abstract] [Full Text]

				J. D. Klemperer, J. Zelano, R. E. Helm, K. Berman, K. Ojamaa, I. Klein, O. W. Isom, and K. Krieger Triiodothyronine improves left ventricular function without oxygen wasting effects after global hypothermic ischemia J. Thorac. Cardiovasc. Surg., March 1, 1995; 109(3): 457 - 465. [Abstract] [Full Text]

				O. Kawaguchi, J. S. Sapirstein, W. B. Daily, W. E. Pae, and W. S. Pierce Left ventricular mechanics during synchronous left atrial-aortic bypass J. Thorac. Cardiovasc. Surg., June 1, 1994; 107(6): 1503 - 1511. [Abstract] [Full Text]

				O. Kawaguchi, Y. Goto, S. Futaki, Y. Ohgoshi, H. Yaku, and H. Suga The effects of dynamic cardiac compression on ventricular mechanics and energetics: Role of ventricular size and contractility J. Thorac. Cardiovasc. Surg., March 1, 1994; 107(3): 850 - 859. [Abstract] [Full Text]

				C. J. M. Kerkhof, P. J. W. Van Der Linden, and P. Sipkema Role of myocardium and endothelium in coronary vascular smooth muscle responses to hypoxia Am J Physiol Heart Circ Physiol, April 1, 2002; 282(4): H1296 - H1303. [Abstract] [Full Text] [PDF]