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Circulation Research. 1983;53:16-23

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Circulation Research, Vol 53, 16-23, Copyright © 1983 by American Heart Association

ARTICLES

Phenytoin reduces calcium current in the cardiac Purkinje fiber

T Scheuer and RS Kass

We have investigated the effects of phenytoin on the electrical and mechanical activity of isolated calf and dog cardiac Purkinje fibers. Phenytoin (5-100 microM) lowers and shortens the plateau phase of the Purkinje fiber action potential and reduces twitch tension. We studied the ionic basis of these effects by combining a conventional two- microelectrode voltage clamp procedure with pharmacological techniques that allow separation of time-dependent plateau membrane currents. We find that phenytoin reduces voltage-dependent calcium current in the Purkinje fiber. In addition, this drug slightly reduces two time- dependent outward currents. These effects of phenytoin on membrane current account, at least in part, for its influence on the action potential and twitch tension.




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