Donate Help Contact The AHA Sign In Home
American Heart Association
Circulation Research
Search: search_blue_button Advanced Search
« Previous Article | Table of Contents | Next Article »
Circulation Research. 1981;49:478-485

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bevan, R. D.
Right arrow Articles by Tsuru, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bevan, R. D.
Right arrow Articles by Tsuru, H.

Circulation Research, Vol 49, 478-485, Copyright © 1981 by American Heart Association

ARTICLES

Functional and structural changes in the rabbit ear artery after sympathetic denervation

RD Bevan and H Tsuru

We studied the tissue weight, dimensions, contractility, elasticity, and sensitivity to exogenous norepinephrine (NE) of denervated and innervated segments of the central ear arteries of white New Zealand rabbits. Three different age groups received unilateral superior cervical ganglionectomies, "growing" at 3-4 weeks, "young adult" at 9- 11 weeks, and "mature" at 16-20 weeks. In the growing group, 8 weeks after ganglionectomy, the denervated arteries showed mean decreases in tissue weight (11%), total wall thickness (12+), cross-sectional area of media (17%), contractility (16%), and increases in the tangential modulus of elasticity and sensitivity to NE (2.3-fold) compared to the contralateral control vessels. The change in medial cross-sectional area was significant in the growing and young adult but not the mature animals. The other changes, however, although consistently seen, differed quantitatively among the groups. These results indicate that an intact innervation is necessary for normal development and maintenance of the artery wall. However, the precise consequences of this influence vary at different ages. Whether this influence involves a special trophic factor is not known.


This article has been cited by other articles:


Home page
 Pers Soc Psychol BullHome page
R. M. Wenzlaff and J. P. LePage
The Emotional Impact of Chosen and Imposed Thoughts
Pers Soc Psychol Bull, December 1, 2000; 26(12): 1502 - 1514.
[Abstract] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
F. R. M. Stassen, R. G. H. T. Maas, P. M. H. Schiffers, G. M. J. Janssen, and J. G. R. De Mey
A Positive and Reversible Relationship Between Adrenergic Nerves and Alpha-1A Adrenoceptors in Rat Arteries
J. Pharmacol. Exp. Ther., January 1, 1998; 284(1): 399 - 405.
[Abstract] [Full Text]

Home page
 HypertensionHome page
A. A. Mangoni, L. Mircoli, C. Giannattasio, G. Mancia, and A. U. Ferrari
Effect of Sympathectomy on Mechanical Properties of Common Carotid and Femoral Arteries
Hypertension, November 1, 1997; 30(5): 1085 - 1088.
[Abstract] [Full Text]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
D. deBlois, S.M. Schwartz, E.M. van Kleef, J.E. Su, K.A. Griffin, A.K. Bidani, M.J.A.P. Daemen, and D.M. Lombardi
Chronic {alpha}1-Adrenoreceptor Stimulation Increases DNA Synthesis in Rat Arterial Wall: Modulation of Responsiveness After Vascular Injury
Arterioscler Thromb Vasc Biol, September 1, 1996; 16(9): 1122 - 1129.
[Abstract] [Full Text]

Home page
 HypertensionHome page
M. J.A.P. Daemen and J. G.R. De Mey
Regional Heterogeneity of Arterial Structural Changes
Hypertension, April 1, 1995; 25(4): 464 - 473.
[Abstract] [Full Text]


Circulation Research Home | Subscriptions | Archives | Feedback | Authors | Help | AHA Journals Home | Search
Copyright © 1981 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited.