Donate Help Contact The AHA Sign In Home
American Heart Association
Circulation Research
Search: search_blue_button Advanced Search
« Previous Article | Table of Contents | Next Article »
Circulation Research. 1981;49:337-341

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rorie, D. K.
Right arrow Articles by Tyce, G. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rorie, D. K.
Right arrow Articles by Tyce, G. M.

Circulation Research, Vol 49, 337-341, Copyright © 1981 by American Heart Association

ARTICLES

Prejunctional inhibition of norepinephrine release caused by acetylcholine in the human saphenous vein

DK Rorie, NJ Rusch, JT Shepherd, PM Vanhoutte and GM Tyce

We performed experiments to determine whether or not acetylcholine exerts a prejunctional inhibitory effect on adrenergic neurotransmission in the human blood vessel wall. Rings of human greater saphenous veins were prepared 2 to 15 hours after death and mounted for isometric tension recording in organ chambers filled with Krebs-Ringer solution. Acetylcholine depressed contractile responses to electric activation of the sympathetic nerve endings significantly more than those to exogenous norepinephrine; the relaxations caused by the cholinergic transmitter were antagonized by atropine. Helical strips were incubated with [3H]norepinephrine and mounted for superfusion. Electric stimulation augmented the fractional release of labeled norepinephrine. Acetylcholine caused a depression of the evoked 3H release which was antagonized by atropine but not by hexamethonium. These experiments demonstrate that, as in animal cutaneous veins, there are prejunctional inhibitory muscarinic receptors on the adrenergic nerve endings in the human saphenous vein. By contrast, the human vein also contains postjunctional inhibitory muscarinic receptors.


This article has been cited by other articles:


Home page
 CirculationHome page
J. A. Taylor, C. W. Myers, N. Montano, C. Cogliati, A. Porta, M. Pagani, A. Malliani, K. Narkiewicz, F. M. Abboud, and V. K. Somers
Mathematical Treatment of Autonomic Oscillations - 2 • Response
Circulation, October 12, 1999; 100 (15): e64 - e64.
[Full Text] [PDF]

Home page
 IOVSHome page
M. Toda, T. Okamura, K. Ayajiki, and N. Toda
Neurogenic Vasoconstriction as Affected by Cholinergic and Nitroxidergic Nerves in Dog Ciliary and Ophthalmic Arteries
Invest. Ophthalmol. Vis. Sci., July 1, 1999; 40(8): 1753 - 1760.
[Abstract] [Full Text] [PDF]


Circulation Research Home | Subscriptions | Archives | Feedback | Authors | Help | AHA Journals Home | Search
Copyright © 1981 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited.