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Circulation Research. 1977;41:865-869

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Circulation Research, Vol 41, 865-869, Copyright © 1977 by American Heart Association

ARTICLES

Lack of correlation of plasma norepinephrine and dopamine-beta- hydroxylase in hypertensive and normotensive subjects

CR Lake, MG Ziegler, M Coleman and IJ Kopin

Dopamine-beta-hydroxylase (DBH) and norepinephrine (NE) have been determined in over 350 plasma samples from 174 subjects while resting supine (basal sample), standing, or exercising. Although increments in both NE and DBH were found with postural change, the further increase in plasma levels of NE during exertion was not attended by any change in levels of DBH. There was no significant correlation between basal levels of DBH and NE nor was there any correlation in their increments after standing or exercising. DBH activity in plasma of subjects with moderate essential hypertension was not different from that of normotensive subjects. It is concluded that plasma DBH is a poor index of acute sympathetic neuronal activity.


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 Arch Gen PsychiatryHome page
S. Castellani, M. G. Ziegler, D. P. van Kammen, P. E. Alexander, S. G. Siris, and C. R. Lake
Plasma Norepinephrine and Dopamine-{beta}-Hydroxylase Activity in Schizophrenia
Arch Gen Psychiatry, October 1, 1982; 39(10): 1145 - 1149.
[Abstract] [PDF]


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