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Circulation Research. 1956;4:440-443

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(Circulation Research. 1956;4:440.)
© 1956 American Heart Association, Inc.

In Vivo Fibrinolytic Activity and Pharmacology of Various Plasmin (Fibrinolysin) Preparations

N. BACK D.Sc.1, J. L. AMBRUS M.D. PH.D.1, S. GOLDSTEIN M.Sc.1, J. W. E. HARRISSON D.Sc.1

1 Department of Pharmacology, Philadelphia College of Pharmacy and Science, Graduate School, Philadelphia, Pa., and the Roswell Park Memorial Institute, Buffalo, N. Y.

A quantitative method based on the disappearance of I131 labeled fibrin has been used to study the in vivo effect of fibrinolytic agents. Various preparations of human and bovine plasmin were found to lyse clots effectively. The minimal effective dose of human plasmin prepared by the method of Kline was 15 Loomis units/Kg. Plasmin preparations given intravenously produced hypotension and leukopenia followed by leukocytosis. Doses above 30 Loomis units/Kg. caused decrease in fibrinogen level and clotting index.




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