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Circulation Research. 1956;4:376-380

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(Circulation Research. 1956;4:376.)
© 1956 American Heart Association, Inc.

Placental Transfer of Radioactive Digitoxin in Pregnant Women and its Fetal Distribution

GEORGE T. OKITA PH.D.1, ERNEST J. PLOTZ M.D.1, M. EDWARDS DAVIS M.D.1

1 Departments of Pharmacology and of Obstetrics and Gynecology, and the Argonne Cancer Research Hospital, The University of Chicago, Chicago, Ill.

Placental transfer of radioactive C14-digitoxin was investigated in four pregnant women. The concentration of the labeled drug and its metabolic products in the various fetal organs was determined. Less than 1 per cent of the administered glycoside was detected in the fetus as unchanged digitoxin and less than 3.5 per cent as its metabolites. The fetal heart and kidney of 11 to 12 weeks gestation had the highest concentrations. However, at near term the fetal liver, gallbladder and intestine had somewhat similar concentrations. Metabolic conversion of the cardiac glycoside by fetal liver as well as biliary excretion is indicated from the tissue distribution data.

Submitted on January 30, 1956




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[Abstract] [PDF]


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