© 1974 American Heart Association, Inc.
Early and Late Effects of Coronary Artery Occlusion on Canine Purkinje Fibers
1 Section of Cardiology, Veterans Administration Hospital, and the Department of Medicine, University of Miami Medical School Miami, Florida 33125, and the Division of Cardiology, Department of Medicine, Mount Sinai Medical Center, Miami Beach, Florida 33140
The electrophysiological characteristics of subendocardial Purkinje and myocardial cells were studied during acute (within 30 minutes) and chronic (after 10 days) phases of myocardial infarction. Endocardial Purkinje and myocardial electrograms were recorded in vivo with bipolar electrodes before and after occlusion of the anterior descending coronary artery. Also, intracellular and extracellular potentials were recorded in vitro from the endocardial surface of infarcted regions of hearts excised during the acute and chronic phases. In the acute phase, Purkinje and myocardial potentials within the ischemic zone deteriorated in vivo, but they were not markedly delayed. Intracellular recordings in vitro showed partial depolarization of both Purkinje and myocardial cells. In the chronic phase, extracellular and intracellular Purkinje potentials recorded in vivo and in vitro from the infarcted zone usually did not differ from normal. No myocardial potentials were recorded from the endocardial surface of the chronic infarcts. Thus, subendocardial Purkinje and myocardial cells are affected early in infarction, but many Purkinje cells survive and return to normal.
Key Words: myocardial cells • transmembrane potentials • chronic infarcts • acute ischemia • automaticity • conduction
Submitted on January 30, 1974
Accepted on May 23, 1974
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