© 1973 American Heart Association, Inc.
Depressed Transmembrane Potentials during Experimentally Induced Ventricular Failure in Cats
1 Department of Pharmacology, College of Physicians and Surgeons, Columbia University New York, New York 10032
Transmembrane potentials and isometric force were recorded in right ventricular muscles from cats with right ventricular failure 3-127 days after chronic partial pulmonary artery obstruction. For the majority of failed muscles (at 36°C, 30 stimuli/min), resting potential, action potential overshoot, action potential maximum rate of rise, isometric active force at optimal length (Po), and dP/dt were decreased compared with the same parameters in normal muscles. Time to peak force and duration of contraction were unaltered. Action potential configuration was changed and action potential duration was lengthened in failed muscles. Epinephrine (10-6M) markedly increased Po and resting potential in severely depolarized failed muscles. These data suggest that electrical depression might exacerbate the contractile deficit in experimental chronic right ventricular failure.
Key Words: cardiac muscle • congestive heart failure • ventricular systolic hypertension • microelectrode techniques • elevated ventricular end-diastolic pressure • isometric force • resting potential • action potential amplitude • epinephrine
Submitted on October 6, 1972
Accepted on March 8, 1973
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