© 1972 American Heart Association, Inc.
Effects of Acetylcholine on Automaticity and Conduction in the Proximal Portion of the His-Purkinje Specialized Conduction System of the Dog
1 Krannert Institute of Cardiology, Marion County General Hospital, Department of Medicine, Indiana University School of Medicine Indianapolis, Indiana 46202
Conventional intracellular recordings from the bundle of His and right bundle branch of the canine heart demonstrated that the slope of diastolic depolarization is markedly depressed by superfusion with relatively small concentrations (4-8 µg/ml) of acetylcholine. As the cells become less automatic, take-off potential increases, rise time of phase 0 is reduced, action potential amplitude increases, and conduction proceeds more rapidly.
Key Words: spontaneous phase 4 depolarization • right bundle branch • transmembrane action potential • determinants of conductivity • innervation of the heart
Submitted on July 30, 1971
Accepted on November 29, 1971
This article has been cited by other articles:
 |
|
 |
|
  J. F. Alison, J. A. Yeung-Lai-Wah, M. Schulzer, and C. R. Kerr Characterization of Junctional Rhythm After Atrioventricular Node Ablation Circulation, January 1, 1995; 91(1): 84 - 90. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. T. Bigger Jr, S. J. Kantor, A. H. Glassman, and J. M. Perel Is Physostigmine Effective for Cardiac Toxicity of Tricyclic Antidepressant Drugs? JAMA, March 28, 1977; 237(13): 1311 - 1311. [Abstract] [PDF]
|
|
|
|
 |
|
 S. E. EPSTEIN, R. E. GOLDSTEIN, D. R. REDWOOD, K. M. KENT, and E. R. SMITH The Early Phase of Acute Myocardial Infarction: Pharmacologic Aspects of Therapy Ann Intern Med, June 1, 1973; 78(6): 918 - 936. [Abstract] [PDF]
|
|