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Circulation Research. 1955;3:297-305

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(Circulation Research. 1955;3:297.)
© 1955 American Heart Association, Inc.

Sodium Tolerance in Experimental Hypertension

SYDNEY M. FRIEDMAN M.D.1, J. A. M. HINKE 1, DAVID F. HARDWICK 1, With the collaboration of CONSTANCE L. FRIEDMAN, PH.D.

1 Department of Anatomy, The University of British Columbia, Vancouver, Canada

A sodium tolerance test was applied to rats subjected to three diverse procedures for the production of experimental renal and hormonal hypertension. Sodium tolerance was impaired in all three types of hypertension to the extent that an accelerated excretion of the imposed sodium load occurred, although there was no change in the plasma sodium level. The disturbance was proportional to the height of the blood pressure but occurred even in those treated rats which remained normotensive.

Submitted on December 22, 1954




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F. M. STURTEVANT
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Ann Intern Med, December 1, 1958; 49(6): 1281 - 1293.
[Abstract] [PDF]


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