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Circulation Research. 1955;3:293-296

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(Circulation Research. 1955;3:293.)
© 1955 American Heart Association, Inc.

Tissue Permeability--a Factor in Atherogenesis

Studies with Cortisone and Hyaluronidase

CHUN-I WANG M.D.1, LOUIS E. SCHAEFER M.D.1, DAVID ADLERSBERG M.D.1

1 Departments of Medicine and Chemistry, The Mount Sinai Hospital, New York 29, N. Y.

Cortisone has a retarding effect on atherogenesis in cholesterol-fed rabbits, despite higher plasma cholesterol levels. This effect of cortisone is prevented by administration of hyaluronidase. The latter intensifies atherosclerosis and deposition of cholesterol in the liver.

Submitted on December 17, 1954




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[Abstract] [PDF]


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