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Circulation Research. 1955;3:259-263

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(Circulation Research. 1955;3:259.)
© 1955 American Heart Association, Inc.

Effects of Acute and Chronic Digoxin Administration in Dogs with Right-Sided Congestive Heart Failure Produced by Pulmonary Artery Constriction

JAMES O. DAVIS PH.D., M.D.1, DAVID S. HOWELL M.D.1, ROBERT E. HYATT M.D.1

1 Laboratory of Kidney and Electrolyte Metabolism, National Heart Institute, National Institutes of Health, Public Health Service, Department of Health, Education and Welfare, Bethesda 14, Maryland

Acute and chronic responses to digoxin have been studied in dogs with cardiac failure secondary to constriction of the pulmonary artery. Cardiovascular and renal hemodynamic function improved and, frequently, a striking increase in sodium (Na) excretion resulted. The data suggest a direct myocardial action of digoxin and provide evidence of impaired myocardial function similar to that observed in patients with congestive heart failure.

Submitted on November 22, 1954




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[Abstract] [PDF]


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