© 1970 American Heart Association, Inc.
Prostaglandin-Like Substances Appearing in Canine Renal Venous Blood During Renal Ischemia
Their Partial Characterization By Pharmacologic And Chromatographic Procedures
1 Department of Internal Medicine, St. Louis University School of Medicine St. Louis, Missouri 63104
Renal prostaglandins (PCs) might mediate an antihypertensive function of the kidney. The blood-superfused organ technique possesses the sensitivity (threshold < 0.4 ng/ml blood) and specificity required for identification of PGs in blood. Induction of unilateral renal ischemia in 14 chloraloseanesthetized dogs reduced renal blood flows from a mean value of 257 to 109 ml/min on the ischemic side and from 250 to 209 ml/min on the contralateral side. Concomitantly, PG-like substances were detected by assay organs in the venous blood of ischemic (13 experiments) and contralateral (11 experiments) kidneys. In one experiment, in a spontaneously hypertensive dog, PGs were not detected during renal ischemia.
Renal venous blood and renal medullary tissue were extracted for acidic lipids and assayed for PG-like substances. Extracts of venous blood collected during renal ischemia and extracts of renal medulla yielded substances with biological activity indistinguishable from PG-like substances or PG standards. Chromatographic characterization of PG-like substances suggests that they are predominantly a mixture of PGE2 and PGF2
.
Key Words: antihypertensive function of kidney • angiotensin II • blood-superfused organ technique • renal medulla • acidic lipids • renal prostaglandins • renal blood flows • renal vascular hypertension
Submitted on March 24, 1970
Accepted on September 4, 1970
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