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Circulation Research. 1969;25:215-229

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(Circulation Research. 1969;25:215.)
© 1969 American Heart Association, Inc.

Blood Flow in Cutaneous Tissue in Man Studied by Washout of Radioactive Xenon

PER SEJRSEN 1

1 Department of Clinical Physiology, Bispebjerg Hospital, Copenhagen, and Department I, Burns Unit, Municipal Hospital Copenhagen, Denmark

Washout of 133xenon from a local depot in cutaneous tissue has been investigated in man to develop a method for blood flow measurement in that tissue. The tissue was labeled both by injecting 133xenon in saline solution intracutaneously and by a nontraumatic epicutaneous application technique. The initial selectivity of the labeling and the subsequent accumulation of 133xenon in subcutaneous tissue were examined by radioautography and by a special tissue separation technique. From the observations a two-compartment clearance model is suggested by which the cutaneous blood flow can be obtained separately from that of the subcutaneous tissue. Blood flow in the cutaneous tissue in the lateral region of the leg was 5.7 (SD 1.3) ml/100 g · min at an ambient temperature of 19° to 22°C. There were variations between different skin sites.


Key Words: intercompartmental exchange by diffusion • inert gas diffusion • intercompartmental exchange by convection • local labeling with gaseous isotopes • trauma of injection • residue detection of 133xenon • compartmental analysis • diffusion equilibrium • histamine-induced hyperemia • effective perfusion pressure

Submitted on October 28, 1968
Accepted on June 19, 1969




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