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Circulation Research. 1969;24:9-14

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(Circulation Research. 1969;24:9.)
© 1969 American Heart Association, Inc.

Biochemical Correlates of Cardiac Hypertrophy

II. Increased Rate of RNA Synthesis in Experimental Cardiac Hypertrophy in the Rat

TADASHI KOIDE M.D.1 MURRAY RABINOWITZ M.D.1

1 Departments of Medicine and Biochemistry and the Argonne Cancer Research Hospital, operated by the University of Chicago for the United States Atomic Energy Commission, University of Chicago, Chicago, Illinois 60637

Cardiac hypertrophy was produced in rats by banding the ascending aorta. Increases in heart weight and RNA content occurred within 48 hours, indicating that hypertrophy develops rapidly. The total RNA content and the specific radioactivity of RNA labeled with 3H-uridine were determined. The rate of RNA synthesis was estimated from these data and from the specific radioactivity of the myocardial uridine nucleotide pool. The rate of RNA synthesis in hearts of banded animals averaged four times greater than controls on the second postoperative day and about two to three times greater on the fourth to fifth postoperative days. An expansion of the myocardial uridine nucleotide pool was observed in banded rats, but the size of the myocardial adenosine nucleotide pool was not changed. No changesin base composition of 28S, 18S, or 4S RNA were observed following cardiac hypertrophy.


Key Words: experimental aortic constriction • myocardial nucleotides • base composition of RNA • uridine nucleotide pool

Accepted on November 4, 1968




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