© 1968 American Heart Association, Inc.
Interstitial Fluid Pressure
1 Department of Physiology, University of Pretoria, Pretoria, South Africa and from the Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216
2 Department of Physiology, University of Pretoria, Pretoria, South Africa and from the Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216; University of Pretoria, School of Medicine, Department of Physiology and Biochemistry, Pretoria, South Africa
Interstitial fluid pressures in the lung were estimated in 39 dogs from pressure measurements made in implanted perforated capsules. Special operative procedures were used to minimize operative trauma of the lungs and infection and inflammation in and around the implanted capsules. In 86% of the preparations, the x-ray findings indicated little remaining inflammation and edema around the capsules, though autopsy findings indicated that a few of these did still have some edema not detectable by x-rays. In 29 of 34 animals in which x-ray findings indicated no edema, the intracapsular pressure was negative. The average of the measurements in all 34 animals was -5.8 mm Hg (± 0.8 SEM), and in the 29 animals with negative pressure values the average was -7.3 mm Hg (± 0.6 SEM). In eight capsules the pressures were below -10 mm Hg, ranging to -16 mm Hg. Because the tissues around some of the capsules undoubtedly still had varying degrees of inflammation and edema, despite the failure of roentgenograms to show these, it is suggested that the normal interstitial fluid pressure of pulmonary tissues in dogs is somewhat more negative than the capsule pressure measurements indicate, perhaps as low as -10 mm Hg.
Key Words: pulmonary edema • tissue fluids • capillary membrane • interstitial fluid • body fluids • lungs • tissue pressure • dogs
Accepted on December 25, 1967
This article has been cited by other articles:
 |
|
 |
|
  A. T. Marty, J. Prather, J. M. Matloff, and J. Schauble Oncotic Effects of Dilutional Bypass, Albumin, and Diuretics Arch Surg, July 1, 1973; 107(1): 21 - 25. [Abstract] [PDF]
|
|
|
|
 |
|
 C. E. Cross, J. A. Shaver, R. J. Wilson, and E. D. Robin Mitral Stenosis and Pulmonary Fibrosis: Special Reference to Pulmonary Edema and Lung Lymphatic Function Arch Intern Med, February 1, 1970; 125(2): 248 - 254. [Abstract] [PDF]
|
|