Left Ventricular Ejection in Conscious Dogs:

I. Measurement and Significance of the Maximum Acceleration of Blood from the Left Ventricle

¹ Department of Medicine, Charing Cross Hospital Medical School, Fulham Hospital, London, W.6, England

The maximum acceleration of blood from the left ventricle was studied in conscious dogs in which ascending aortic blood flow was measured with an electromagnetic flowmeter; normal values at rest ranged between 5 and 11 g. The left ventricular myocardium was stimulated with intracoronary injections of calcium gluconate and isopropylnorepinephrine; maximum acceleration, peak flow, and the rate of rise of left ventricular pressure were the only parameters, measured or derived, that showed a consistent increase. The largest increase always occurred in maximum acceleration. Changes of posture, with the presumed associated changes in end diastolic dimensions, did not alter the maximum acceleration. The results suggested that maximum acceleration was closely related to the maximum force exerted by the heart in initial systole, and to the maximum initial velocity of shortening of left ventricular muscle. Temporary regional myocardial ischaemia produced larger and earlier decreases in maximum acceleration than in other parameters measured suggesting that it was a sensitive index of myocardial contractile function.

Accepted on February 7, 1966

This article has been cited by other articles:

				M. Cikes, H. Kalinic, A. Baltabaeva, S. Loncaric, C. Parsai, D. Milicic, I. Cikes, G. Sutherland, and B. Bijnens The shape of the aortic outflow velocity profile revisited: is there a relation between its asymmetry and ventricular function in coronary artery disease? Eur J Echocardiogr, October 1, 2009; 10(7): 847 - 857. [Abstract] [Full Text] [PDF]

				A. M. Duncan, E. Lim, D. G. Gibson, and M. Y. Henein Effect of Dobutamine Stress on Left Ventricular Filling in Ischemic Dilated Cardiomyopathy: Pathophysiology and Prognostic Implications J. Am. Coll. Cardiol., August 2, 2005; 46(3): 488 - 496. [Abstract] [Full Text] [PDF]

				A. Duncan, D. Francis, D. Gibson, J. Pepper, and M. Henein Electromechanical left ventricular resynchronisation by coronary artery bypass surgery Eur. J. Cardiothorac. Surg., October 1, 2004; 26(4): 711 - 719. [Abstract] [Full Text] [PDF]

				F. Bauer, M. Jones, T. Shiota, M. S. Firstenberg, J. X. Qin, H. Tsujino, Y. J. Kim, M. Sitges, L. A. Cardon, A. D. Zetts, et al. Left ventricular outflow tract mean systolic acceleration as a surrogatefor the slope of the left ventricular end-systolic pressure-volume relationship J. Am. Coll. Cardiol., October 2, 2002; 40(7): 1320 - 1327. [Abstract] [Full Text] [PDF]

				A M Duncan, C A O'Sullivan, G S Carr-White, D G Gibson, and M Y Henein Long axis electromechanics during dobutamine stress in patients with coronary artery disease and left ventricular dysfunction Heart, October 1, 2001; 86(4): 397 - 404. [Abstract] [Full Text] [PDF]

				A M Duncan, C A O'Sullivan, D G Gibson, and M Y Henein Electromechanical interrelations during dobutamine stress in normal subjects and patients with coronary artery disease: comparison of changes in activation and inotropic state Heart, April 1, 2001; 85(4): 411 - 416. [Abstract] [Full Text]

				N. ABI-GERGES, B. TAVERNIER, A. MEBAZAA, V. FAIVRE, X. PAQUERON, D. PAYEN, R. FISCHMEISTER, and P.-F. MÉRY Sequential Changes in Autonomic Regulation of Cardiac Myocytes after In Vivo Endotoxin Injection in Rat Am. J. Respir. Crit. Care Med., October 1, 1999; 160(4): 1196 - 1204. [Abstract] [Full Text]

				C.-H. Chen, C.-T. Ting, S.-J. Lin, T.-L. Hsu, S.-J. Ho, P. Chou, M.-S. Chang, F. O'Connor, H. Spurgeon, E. Lakatta, et al. Which Arterial and Cardiac Parameters Best Predict Left Ventricular Mass? Circulation, August 4, 1998; 98(5): 422 - 428. [Abstract] [Full Text] [PDF]

				A. D. Waggoner and C. Davis Quantitative Echoca rdiograpy Part III: A Review of Methods for the Assessment of Left Ventricular Systolic Performance by Two-Dimensional and Doppler Echocardiography Journal of Diagnostic Medical Sonography, November 1, 1995; 11(6): 285 - 299. [Abstract] [PDF]

				P. J. Winter, D. C. Deuchar, M. I. M. Noble, D. Trenchard, and A. Guz Relationship Between the Ballistocardiogram and the Movement of Blood from the Left Ventricle in the Dog Cardiovasc Res, April 1, 1967; 1(2): 194 - 200. [Abstract] [PDF]

				D. H. Bergel and G. S. Makin Central and Peripheral Cardiovascular Changes Following Chemical Stimulation of the Surface of the Dog's Heart Cardiovasc Res, January 1, 1967; 1(1): 80 - 90. [Abstract] [PDF]