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Circulation Research. 2009;104:442-454
doi: 10.1161/CIRCRESAHA.108.191270
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(Circulation Research. 2009;104:442.)
© 2009 American Heart Association, Inc.

Reviews

MicroRNAs As Novel Regulators of Angiogenesis

Yajaira Suárez, William C. Sessa

From the Department of Immunobiology (Y.S.), Department of Pharmacology (W.C.S.), and Vascular Biology and Therapeutics Program (Y.S., W.C.S.), Yale University School of Medicine, New Haven, Conn.

Correspondence to William C. Sessa, Yale University School of Medicine, Amistad Research Building, 10 Amistad St, New Haven, CT 06519. E-mail william.sessa{at}yale.edu

This Review is part of a thematic series on MicroRNAs and Heart Disease, which includes the following articles:

Toward MicroRNA-Based Therapeutics for Heart Disease: The Sense in Antisense [2008;103:919–928]

The Emerging Role of MicroRNAs in Cardiac Remodeling and Heart Failure [2008;103:1072–1083]

MicroRNAs As Novel Regulators of Angiogenesis

Role of MicroRNAs in Cardiac Development
Eric Olson Guest Editor

MicroRNAs are short noncoding RNAs that function as negative regulators of gene expression. Posttranscriptional regulation by miRNAs is important for many aspects of development, homeostasis, and disease. Endothelial cells are key regulators of different aspects of vascular biology, including the formation of new blood vessels (angiogenesis). Here, we review the approaches and current experimental evidence for the involvement of miRNAs in the regulation of the angiogenic process and their potential therapeutic applications for vascular diseases associated with abnormal angiogenesis.


Key Words: endothelial cells • Dicer • gene expression • VEGF • cancer






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