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(Circulation Research. 2008;103:1072.)
© 2008 American Heart Association, Inc.

Reviews

The Emerging Role of MicroRNAs in Cardiac Remodeling and Heart Failure

Vijay Divakaran, Douglas L. Mann

From the Winters Center for Heart Failure Research, Section of Cardiology, Department of Medicine, Department of Molecular Physiology and Biophysics, Baylor College of Medicine, and the Texas Heart Institute at St. Luke’s Episcopal Hospital, Houston, Tex.

Correspondence to Douglas L. Mann, MD, Faculty Center, 1709 Dryden Rd, BCM620, FC 9.30, Houston, TX 77030. E-mail dmann{at}bcm.tmc.edu

This Review is part of a thematic series on MicroRNAs and Heart Disease, which includes the following articles:

Toward MicroRNA-Based Therapeutics for Heart Disease: The Sense in Antisense [2008;103:919–928]

The Emerging Role of MicroRNAs in Cardiac Remodeling and Heart Failure

Role of MicroRNAs in Cardiac Development

MicroRNAs and Angiogenesis
Eric Olson Guest Editor

Recent studies have suggested a potentially important role for a family of tiny regulatory RNAs, known as microRNAs (miRNAs or miRs), in the control of diverse aspects of cardiac function in health and disease. Although the field of miRNA biology is relatively new, there is emerging evidence that miRNAs may play an important role in the pathogenesis of heart failure through their ability to regulate the expression levels of genes that govern the process of adaptive and maladaptive cardiac remodeling. Here, we review the biology of miRNAs in relation to their role in modulating various aspects of the process of cardiac remodeling, as well as discuss the potential application of miRNA biology to the field of heart failure.

Key Words: heart failure • cardiac remodeling • microRNAs • neurohormonal activation • arrhythmia

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