This Article Full Text Full Text (PDF) Data Supplement All Versions of this Article: 102/4/465    most recent CIRCRESAHA.107.161778v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Zhang, Q. Articles by Chiamvimonvat, N. Search for Related Content PubMed PubMed Citation Articles by Zhang, Q. Articles by Chiamvimonvat, N. Related Collections Arrythmias-basic studies

(Circulation Research. 2008;102:465.)
© 2008 American Heart Association, Inc.

Cellular Biology

Functional Roles of a Ca²⁺-Activated K⁺ Channel in Atrioventricular Nodes

Qian Zhang, Valeriy Timofeyev, Ling Lu, Ning Li, Anil Singapuri, Melissa K. Long, Chris T. Bond, John P. Adelman, Nipavan Chiamvimonvat

From the Division of Cardiovascular Medicine (Q.Z., V.T., L.L., N.L., A.S., M.K.L., N.C.), Department of Internal Medicine, University of California, Davis, Calif; Department of Veterans Affairs (N.C.), Northern California Health Care System, Mather, Calif; Vollum Institute (C.T.B., J.P.A.), Oregon Health and Science University, Portland; and Department of Physiology (Q.Z.), University of Zhengzhou, Henan, People’s Republic of China.

Correspondence to Nipavan Chiamvimonvat, Division of Cardiovascular Medicine, University of California, One Shields Ave, GBSF 6315, Davis, CA 95616. E-mail nchiamvimonvat{at}ucdavis.edu

Since the first description of the anatomical atrioventricular nodes (AVNs), a large number of studies have provided insights into the heterogeneity of the structure as well as a repertoire of ion channel proteins that govern this complex conduction pathway between the atria and ventricles. These studies have revealed the intricate organization of multiple nodal and nodal-like myocytes contributing to the unique electrophysiology of the AVN in health and diseases. On the other hand, information regarding the contribution of specific ion channels to the function of the AVN remains incomplete. We reason that the identification of AVN-specific ion channels may provide a more direct and rational design of therapeutic target in the control of AVN conduction in atrial flutter/fibrillation, one of the most common arrhythmias seen clinically. In this study, we took advantage of 2 genetically altered mouse models with overexpression or null mutation of 1 of a small conductance Ca²⁺-activated K⁺ channel isoform, SK2 channel, and demonstrated robust phenotypes of AVN dysfunction in these experimental models. Overexpression of SK2 channels results in the shortening of the spontaneous action potentials of the AVN cells and an increase in the firing frequency. On the other hand, ablation of the SK2 channel results in the opposite effects on the spontaneous action potentials of the AVN. Furthermore, we directly documented the expression of SK2 channel in mouse AVN using multiple techniques. The new insights may have important implications in providing novel drug targets for the modification of AVN conduction in the treatment of atrial arrhythmias.

Key Words: K_Ca2.2 channel • SK2 channel • atrioventricular nodes

This article has been cited by other articles:

				Y. Lu, Y. Zhang, H. Shan, Z. Pan, X. Li, B. Li, C. Xu, B. Zhang, F. Zhang, D. Dong, et al. MicroRNA-1 downregulation by propranolol in a rat model of myocardial infarction: a new mechanism for ischaemic cardioprotection Cardiovasc Res, December 1, 2009; 84(3): 434 - 441. [Abstract] [Full Text] [PDF]

				N. Li, V. Timofeyev, D. Tuteja, D. Xu, L. Lu, Q. Zhang, Z. Zhang, A. Singapuri, T. R. Albert, A. V. Rajagopal, et al. Ablation of a Ca2+-activated K+ channel (SK2 channel) results in action potential prolongation in atrial myocytes and atrial fibrillation J. Physiol., March 1, 2009; 587(5): 1087 - 1100. [Abstract] [Full Text] [PDF]