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(Circulation Research. 2007;101:125.)
© 2007 American Heart Association, Inc.

Review

Endothelial Precursor Cell Migration During Vasculogenesis

Annette Schmidt, Klara Brixius, Wilhelm Bloch

From the Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sport Medicine, German Sport University Cologne, Germany.

Correspondence to Prof Dr Wilhelm Bloch, Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sport Medicine, German Sport University Cologne, Carl-Diem-Weg 6, D-50933 Cologne, Germany. E-mail w.bloch{at}dshs-koeln.de

This Review is part of a thematic series on Migration of Vascular Cells, which includes the following articles:

Mechanisms of Vascular Smooth Muscle Cell Migration

Endothelial Cell Migration During Angiogenesis

Endothelial Precursor Cell Migration During Vasculogenesis

Leukocyte Migration in the Vascular Wall

Molecular Mechanisms of Endothelial Cell Migration
Kathy K. Griendling Editor

Migration of endothelial precursor cells (so-called "angioblasts" in embryos and "endothelial progenitor cells" in adults) during vasculogenesis is a requirement for the formation of a primary vascular plexus. The migration is initiated by the change of endothelial precursors to their migratory phenotype. The endothelial precursor cells are then guided to the position where the primary vascular plexus is formed. Migration is stopped by the reversion of the cells to their nonmigratory phenotype. A combination of regulatory mechanisms and factors controls this process. These include gradients of soluble factors, extracellular matrix–cell interaction and cell–cell interaction. In this review, we give an overview of the regulation of angioblast migration during embryonic vasculogenesis and its relationship to the migration of endothelial progenitors during postnatal vascular development.

Key Words: angioblasts • endothelial progenitors • extracellular matrix • growth factors

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