doi: 10.1161/01.RES.0000264500.11888.f0
© 2007 American Heart Association, Inc.
Reviews |
Ubiquitin and Ubiquitin-Like Proteins in Protein Regulation
From the Division of Cardiovascular Diseases (J.H., A.L.) and the Division of Nephrology and Hypertension (L.O.L), Mayo Clinic, Rochester, Minn.
Correspondence to Amir Lerman, MD, Division of Cardiovascular Diseases, Mayo Clinic Rochester, 200 First St SW, Rochester, MN 55905. E-mail lerman.amir{at}mayo.edu
This Review is part of a thematic series on Ubiquitination, which includes the following articles:
Regulation of G Protein and Mitogen-Activated Protein Kinase Signaling by Ubiquitination: Insights From Model Organisms
Heart Failure and Protein Quality Control
Seven-Transmembrane Receptors and Ubiquitination
Ubiquitin and Ubiquitin-Like Proteins in Protein Regulation
Sudha K. Shenoy Guest Editor
The discovery of the ubiquitin system was awarded with the Nobel Prize in Chemistry in 2004. Labeling of intracellular proteins for degradation by a multienzymatic complex, called the proteasome, was identified as the main function of this system. Subsequently, it was discovered that the attachment of ubiquitin to proteins can modify their function without degradation. Finally, a number of other molecules were recognized to be conjugated to proteins in a manner similar to ubiquitin and were henceforth called ubiquitin-like proteins. This review provides an overview of this class of molecules and its implication for function, subcellular location, and half-life of proteins.
Key Words: cell cycle • inflammation • metabolism • protein • ubiquitinubiquitin-like proteins
This article has been cited by other articles:
 |
|
 |
|
  Y. Huang, Z. Su, Y. Li, Q. Zhang, L. Cui, Y. Su, C. Ding, M. Zhang, C. Feng, Y. Tan, et al. Expression and Purification of Glutathione Transferase-Small Ubiquitin-Related Modifier-Metallothionein Fusion Protein and Its Neuronal and Hepatic Protection against D-Galactose-Induced Oxidative Damage in Mouse Model J. Pharmacol. Exp. Ther., May 1, 2009; 329(2): 469 - 478. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Quezada, S. W. Hicks, J. E. Galan, and C. E. Stebbins A family of Salmonella virulence factors functions as a distinct class of autoregulated E3 ubiquitin ligases PNAS, March 24, 2009; 106(12): 4864 - 4869. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Higashi, S. Sukhanov, S. Parthasarathy, and P. Delafontaine The ubiquitin ligase Nedd4 mediates oxidized low-density lipoprotein-induced downregulation of insulin-like growth factor-1 receptor Am J Physiol Heart Circ Physiol, October 1, 2008; 295(4): H1684 - H1689. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Wang, H. Zhang, D. Iyer, X.-H. Feng, and R. J. Schwartz Regulation of Cardiac Specific nkx2.5 Gene Activity by Small Ubiquitin-like Modifier J. Biol. Chem., August 22, 2008; 283(34): 23235 - 23243. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Herrmann, S. M. Soares, L. O. Lerman, and A. Lerman Potential Role of the Ubiquitin-Proteasome System in Atherosclerosis: Aspects of a Protein Quality Disease J. Am. Coll. Cardiol., May 27, 2008; 51(21): 2003 - 2010. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B.-Y. Kang, S. Tsoi, Shan Zhu, Shenghui Su, and H. H. Kay Differential Gene Expression Profiling in HELLP Syndrome Placentas Reproductive Sciences, March 1, 2008; 15(3): 285 - 294. [Abstract] [PDF]
|
|
|
|
 |
|
 R. Meller, S. J. Thompson, T. A. Lusardi, A. N. Ordonez, M. D. Ashley, V. Jessick, W. Wang, D. J. Torrey, D. C. Henshall, P. R. Gafken, et al. Ubiquitin Proteasome-Mediated Synaptic Reorganization: A Novel Mechanism Underlying Rapid Ischemic Tolerance J. Neurosci., January 2, 2008; 28(1): 50 - 59. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Fukai Targeting Proteasome Worsens Atherosclerosis Circ. Res., October 26, 2007; 101(9): 859 - 861. [Full Text] [PDF]
|
|