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(Circulation Research. 2007;100:1249.)
© 2007 American Heart Association, Inc.

Reviews

Adipose-Derived Stem Cells for Regenerative Medicine

Jeffrey M. Gimble, Adam J. Katz, Bruce A. Bunnell

From the Stem Cell Biology Laboratory and Clinical Nutrition Research Unit, Pennington Biomedical Research Center (J.M.G.), Louisiana State University System, Baton Rouge; Department of Plastic and Maxillofacial Surgery (A.J.K.), University of Virginia, Charlottesville; and Tulane University Primate Research Center (B.A.B.), Covington, La.

Correspondence to Dr Jeffrey Gimble, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge 70808. E-mail gimblejm{at}pbrc.edu

This Review is part of a thematic series on the Pathobiology of Obesity, which includes the following articles:

Adipose-Derived Stem Cells for Regenerative Medicine

Obesity: Energy Metabolism at the Heart of the Problem

Lipid Disorders and the Metabolic Syndrome

Obesity and Leptin Resistance

Adiponectin as a Cardiovascular Protectant
Gary Lopaschuk Guest Editor

The emerging field of regenerative medicine will require a reliable source of stem cells in addition to biomaterial scaffolds and cytokine growth factors. Adipose tissue represents an abundant and accessible source of adult stem cells with the ability to differentiate along multiple lineage pathways. The isolation, characterization, and preclinical and clinical application of adipose-derived stem cells (ASCs) are reviewed in this article.

Key Words: adipose tissue • adult stem cells • bone marrow stromal cell • differentiation • tissue engineering

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