doi: 10.1161/01.RES.0000259593.07661.1e
© 2007 American Heart Association, Inc.
Reviews |
Endothelial Cell Migration During Angiogenesis
From the Le Centre de recherche en cancérologie de l’Université Laval, Québec, Canada.
Correspondence to Dr Jacques Huot, Centre de recherche en cancérologie de l’Université Laval, L’Hôtel-Dieu de Québec, 9 rue McMahon, Québec, Canada, G1R 2J6. E-mail Jacques.Huot{at}phc.ulaval.ca
This Review is part of a thematic series on Migration of Vascular Cells, which includes the following articles:
Endothelial Cell Migration During Angiogenesis
Mechanisms of Vascular Smooth Muscle Cell Migration
Leukocyte Migration in the Vascular Wall
Molecular Mechanisms of Endothelial Cell Migration
Endothelial Migration in Vascular Development
Kathy K. Griendling Editor
Endothelial cell migration is essential to angiogenesis. This motile process is directionally regulated by chemotactic, haptotactic, and mechanotactic stimuli and further involves degradation of the extracellular matrix to enable progression of the migrating cells. It requires the activation of several signaling pathways that converge on cytoskeletal remodeling. Then, it follows a series of events in which the endothelial cells extend, contract, and throw their rear toward the front and progress forward. The aim of this review is to give an integrative view of the signaling mechanisms that govern endothelial cell migration in the context of angiogenesis.
Key Words: endothelial cells • chemotaxis • haptotaxis • mechanotaxis • migration • angiogenesis • VEGF • integrins • actin • remodeling
This article has been cited by other articles:
 |
|
 |
|
  C. Clapp, S. Thebault, M. C. Jeziorski, and G. Martinez De La Escalera Peptide Hormone Regulation of Angiogenesis Physiol Rev, October 1, 2009; 89(4): 1177 - 1215. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. F. Meoli and R. J. White Thrombin induces fibronectin-specific migration of pulmonary microvascular endothelial cells: requirement of calcium/calmodulin-dependent protein kinase II Am J Physiol Lung Cell Mol Physiol, October 1, 2009; 297(4): L706 - L714. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Spiering, M. Schmolke, N. Ohnesorge, M. Schmidt, M. Goebeler, J. Wegener, V. Wixler, and S. Ludwig MEK5/ERK5 Signaling Modulates Endothelial Cell Migration and Focal Contact Turnover J. Biol. Chem., September 11, 2009; 284(37): 24972 - 24980. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Zhang, L. Fu, J. Fu, L. Hu, H. Yang, T.-H. Rong, Y. Li, H. Liu, S.-B. Fu, Y.-X. Zeng, et al. Fibroblast Growth Factor Receptor 2-Positive Fibroblasts Provide a Suitable Microenvironment for Tumor Development and Progression in Esophageal Carcinoma Clin. Cancer Res., June 15, 2009; 15(12): 4017 - 4027. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Bhattacharya, J. Kwon, X. Li, E. Wang, S. Patra, J. P. Bida, Z. Bajzer, L. Claesson-Welsh, and D. Mukhopadhyay Distinct role of PLC{beta}3 in VEGF-mediated directional migration and vascular sprouting J. Cell Sci., April 1, 2009; 122(7): 1025 - 1034. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. Brunet-Dunand, C. Vouyovitch, S. Araneda, V. Pandey, L. J.-P. Vidal, C. Print, H. C. Mertani, P. E. Lobie, and J. K. Perry Autocrine Human Growth Hormone Promotes Tumor Angiogenesis in Mammary Carcinoma Endocrinology, March 1, 2009; 150(3): 1341 - 1352. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Ma, D. Zhang, H. Yang, H. Sun, W. Wu, Y. Gan, J. Balducci, Y.-q. Wei, X. Zhao, and Y. Huang Endothelial cell-specific molecule 2 (ECSM2) modulates actin remodeling and epidermal growth factor receptor signaling. Genes Cells, March 1, 2009; 14(3): 281 - 293. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. A. de Jesus Perez, T.-P. Alastalo, J. C. Wu, J. D. Axelrod, J. P. Cooke, M. Amieva, and M. Rabinovitch Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt-{beta}-catenin and Wnt-RhoA-Rac1 pathways J. Cell Biol., January 12, 2009; 184(1): 83 - 99. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Benndorf, E. Schwedhelm, A. Gnann, R. Taheri, G. Kom, M. Didie, A. Steenpass, S. Ergun, and R. H. Boger Isoprostanes Inhibit Vascular Endothelial Growth Factor-Induced Endothelial Cell Migration, Tube Formation, and Cardiac Vessel Sprouting In Vitro, As Well As Angiogenesis In Vivo via Activation of the Thromboxane A2 Receptor: A Potential Link Between Oxidative Stress and Impaired Angiogenesis Circ. Res., October 24, 2008; 103(9): 1037 - 1046. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Mu, W. Wang, and J. C. Schimenti An Allelic Series Uncovers Novel Roles of the BRCT Domain-Containing Protein PTIP in Mouse Embryonic Vascular Development Mol. Cell. Biol., October 15, 2008; 28(20): 6439 - 6451. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Garnaas, K. L. Moodie, M.-l. Liu, G. V. Samant, K. Li, R. Marx, J. M. Baraban, A. Horowitz, and R. Ramchandran Syx, a RhoA Guanine Exchange Factor, Is Essential for Angiogenesis In Vivo Circ. Res., September 26, 2008; 103(7): 710 - 716. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hayashi, H. Sano, S. Seo, and T. Kume The Foxc2 Transcription Factor Regulates Angiogenesis via Induction of Integrin {beta}3 Expression J. Biol. Chem., August 29, 2008; 283(35): 23791 - 23800. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Barkefors, S. Le Jan, L. Jakobsson, E. Hejll, G. Carlson, H. Johansson, J. Jarvius, J. W. Park, N. Li Jeon, and J. Kreuger Endothelial Cell Migration in Stable Gradients of Vascular Endothelial Growth Factor A and Fibroblast Growth Factor 2: EFFECTS ON CHEMOTAXIS AND CHEMOKINESIS J. Biol. Chem., May 16, 2008; 283(20): 13905 - 13912. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Gorshkova, D. He, E. Berdyshev, P. Usatuyk, M. Burns, S. Kalari, Y. Zhao, S. Pendyala, J. G. N. Garcia, N. J. Pyne, et al. Protein Kinase C-{epsilon} Regulates Sphingosine 1-Phosphate-mediated Migration of Human Lung Endothelial Cells through Activation of Phospholipase D2, Protein Kinase C-{zeta}, and Rac1 J. Biol. Chem., April 25, 2008; 283(17): 11794 - 11806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Weis, S.-T. Lim, K. M. Lutu-Fuga, L. A. Barnes, X. L. Chen, J. R. Gothert, T.-L. Shen, J.-L. Guan, D. D. Schlaepfer, and D. A. Cheresh Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK J. Cell Biol., April 3, 2008; 181(1): 43 - 50. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yi, Z. Yi, S.-G. Cho, J. Luo, M. K. Pandey, B. B. Aggarwal, and M. Liu Gambogic Acid Inhibits Angiogenesis and Prostate Tumor Growth by Suppressing Vascular Endothelial Growth Factor Receptor 2 Signaling Cancer Res., March 15, 2008; 68(6): 1843 - 1850. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Wels, R. N. Kaplan, S. Rafii, and D. Lyden Migratory neighbors and distant invaders: tumor-associated niche cells Genes & Dev., March 1, 2008; 22(5): 559 - 574. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. A. Auger, P. D'Orleans-Juste, and L. Germain Adventitia contribution to vascular contraction: Hints provided by tissue-engineered substitutes Cardiovasc Res, September 1, 2007; 75(4): 669 - 678. [Abstract] [Full Text] [PDF]
|
|