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(Circulation Research. 2007;100:782.)
© 2007 American Heart Association, Inc.

Reviews

Endothelial Cell Migration During Angiogenesis

Laurent Lamalice^*, Fabrice Le Boeuf^*, Jacques Huot

From the Le Centre de recherche en cancérologie de l’Université Laval, Québec, Canada.

Correspondence to Dr Jacques Huot, Centre de recherche en cancérologie de l’Université Laval, L’Hôtel-Dieu de Québec, 9 rue McMahon, Québec, Canada, G1R 2J6. E-mail Jacques.Huot{at}phc.ulaval.ca

This Review is part of a thematic series on Migration of Vascular Cells, which includes the following articles:

Endothelial Cell Migration During Angiogenesis

Mechanisms of Vascular Smooth Muscle Cell Migration

Leukocyte Migration in the Vascular Wall

Molecular Mechanisms of Endothelial Cell Migration

Endothelial Migration in Vascular Development
Kathy K. Griendling Editor

Endothelial cell migration is essential to angiogenesis. This motile process is directionally regulated by chemotactic, haptotactic, and mechanotactic stimuli and further involves degradation of the extracellular matrix to enable progression of the migrating cells. It requires the activation of several signaling pathways that converge on cytoskeletal remodeling. Then, it follows a series of events in which the endothelial cells extend, contract, and throw their rear toward the front and progress forward. The aim of this review is to give an integrative view of the signaling mechanisms that govern endothelial cell migration in the context of angiogenesis.

Key Words: endothelial cells • chemotaxis • haptotaxis • mechanotaxis • migration • angiogenesis • VEGF • integrins • actin • remodeling

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