This Article Full Text Full Text (PDF) All Versions of this Article: 100/2/273    most recent 01.RES.0000257777.83431.13v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Huo, Y. Articles by Kassab, G. S. Search for Related Content PubMed PubMed Citation Articles by Huo, Y. Articles by Kassab, G. S. Related Collections Other Vascular biology Other Research

Capillary Perfusion and Wall Shear Stress Are Restored in the Coronary Circulation of Hypertrophic Right Ventricle

From the Department of Biomedical Engineering, Surgery and Cellular and Integrative Physiology, Indiana University–Purdue University Indianapolis.

Correspondence to Ghassan S. Kassab, PhD, Department of Biomedical Engineering, Indiana University–Purdue University Indianapolis, 635 Barnhill Dr, MS 2069, Indianapolis, IN 46202. E-mail gkassab{at}iupui.edu

It has been shown that right ventricle (RV) hypertrophy involves significant compensatory vascular growth and remodeling. The objective of the present study was to determine the functional implications of the vascular growth and remodeling through a full flow analysis of arterial tree down to first capillary segments. A computer reconstruction of RV branches including the proximal right coronary artery to the posterior descending artery was established based on measured morphometric data in arrested, vasodilated porcine heart. The flows were computed throughout the reconstructed trees based on conservation of mass and momentum and appropriate pressure boundary conditions. It was found that the flow rate was significantly increased in large epicardial coronary arteries in hypertrophic as compared with control hearts but normalized in the intramyocardial coronary arteries and smaller vessels in RV hypertrophy primarily because of the significant increase in number of arterioles. Furthermore, the wall shear stress was restored to nearly homeostatic levels throughout most of the vasculature after 5 weeks of RV hypertrophy. The compensatory remodeling in RV hypertrophy functionally restores the perfusion at the arteriolar and capillary level and wall shear stress in most of larger vessels. This is the first full analysis of coronary arterial tree, with millions of vessels, in cardiac hypertrophy that reveals the compensatory adaptation of structure to function.

Key Words: right coronary artery • intravascular pressure • coronary flow • right ventricular hypertrophy

This article has been cited by other articles:

				Y. Huo and G. S. Kassab Effect of compliance and hematocrit on wall shear stress in a model of the entire coronary arterial tree J Appl Physiol, August 1, 2009; 107(2): 500 - 505. [Abstract] [Full Text] [PDF]

				B. Kaimovitz, Y. Huo, Y. Lanir, and G. S. Kassab Diameter asymmetry of porcine coronary arterial trees: structural and functional implications Am J Physiol Heart Circ Physiol, February 1, 2008; 294(2): H714 - H723. [Abstract] [Full Text] [PDF]

				Y. Huo, T. Wischgoll, and G. S. Kassab Flow patterns in three-dimensional porcine epicardial coronary arterial tree Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H2959 - H2970. [Abstract] [Full Text] [PDF]