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(Circulation Research. 2007;100:1686.)
© 2007 American Heart Association, Inc.

Reviews

Role of Krüppel-Like Transcription Factors in Endothelial Biology

G. Brandon Atkins, Mukesh K. Jain

From the Cardiovascular Research Institute, Case Western Reserve University, Cleveland, Ohio.

Correspondence to Mukesh K. Jain, MD, Director, Case Cardiovascular Research Institute, Case Western Reserve University, The Iris S. & Bert L. Wolstein Research Building, Room 4537, 2103 Cornell Rd, Cleveland, OH 44106. E-mail mukesh.jain2{at}case.edu

This Review is part of a thematic series on Transcription Factors, which includes the following articles:

Regulation of Vascular Inflammation and Remodeling by ETS Factors

Myocardin-Related Transcription Factors: Critical Coactivators Regulating Cardiovascular Development and Adaptation

Notch Signaling in Blood Vessels: Who Is Talking to Whom About What?

Role of Krüppel-Like Transcription Factors in Endothelial Biology

Forkhead Factors in Cardiovascular Biology
Mukesh Jain Guest Editor

Krüppel-like factors are members of the zinc finger family of transcription factors that have been implicated as playing key roles in regulating cellular differentiation and tissue development. Studies over the past several years support an important role for this family of factors in vascular biology. This review summarizes the role of Krüppel-like factors in endothelial cell biology.

Key Words: endothelium • transcription • vessels • gene expression • gene regulation

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