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(Circulation Research. 2007;100:1556.)
© 2007 American Heart Association, Inc.

Reviews

Notch Signaling in Blood Vessels

Who Is Talking to Whom About What?

Jennifer J. Hofmann, M. Luisa Iruela-Arispe

From the Molecular Biology Institute (J.J.H., M.L.I.-A.), Department of Molecular, Cell and Developmental Biology (M.L.I.-A.), and The Jonsson Comprehensive Cancer Center (M.L.I.-A.), University of California, Los Angeles.

Correspondence to Dr Luisa Iruela-Arispe, Molecular Biology Institute, UCLA, 611 Charles Young Dr E, Paul Boyer Hall, Room 559, Los Angeles, CA 90095. E-mail arispe{at}mbi.ucla.edu

This Review is part of a thematic series on Transcription Factors, which includes the following articles:

Regulation of Vascular Inflammation and Remodeling by ETS Factors

Myocardin-Related Transcription Factors: Critical Coactivators Regulating Cardiovascular Development and Adaptation

Notch Signaling in Blood Vessels: Who Is Talking to Whom About What?

Role of Kruppel-Like Transcription Factors in Endothelial Biology

Forkhead Factors in Cardiovascular Biology
Mukesh Jain Guest Editor

It has become increasingly clear that the Notch signaling pathway plays a critical role in the development and homeostasis of the cardiovascular system. This notion has emerged from loss- and gain-of-function analysis and from the realization that several hereditary cardiovascular disorders originate from gene mutations that have a direct impact on Notch signaling. Current research efforts are focused on determining the specific cellular and molecular effects of Notch signaling. The rationale for this has stemmed from the clinical importance and therapeutic potential of modulating vascular formation during various disease states. A more complete appreciation of Notch signaling, as it relates to vascular morphogenesis, requires an in-depth knowledge of expression patterns of the various signaling components and a comprehensive understanding of downstream targets. The goal of this review is to summarize current knowledge regarding Notch signaling during vascular development and within the adult vascular wall. Our focus is on the genetic analysis and cellular experiments that have been performed with Notch ligands, receptors, and downstream targets. We also highlight questions and controversies regarding the contribution of this pathway to vascular development.

Key Words: Alagille syndrome • CADASIL • endothelium • smooth muscle • vascular development

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